Anavex Life Sciences Corp (AVXL)

[falconer66a]

Blarcamesine; in the steps of Lister, Semmelweis, Pasteur, et al.

The colleges hammer into them [doctors in training] the chain of command protocol, each dutifully honoring the prior and successor.

This has been how formal or recognized medicine has worked for several centuries. The only people who really know, who should be listened to, are the prior experts, the people who wrote the textbooks, who hold the most vautened positions in hospitals and research organizations.

New ideas that don't fit legacy or traditional understandings are simply dismissed. Think not? Study (with an open mind) the history of the "germ theory," the notion set out in the 19th century that most diseases are caused by "germs," microscopic, unseen, seemingly self-reproducing organisms.

Check the story of Semmelweis, an early proponant of the germ theory:
https://en.wikipedia.org/wiki/Ignaz_Semmelweis Learn what happened to him.

For a broader overview of the acceptance of the Germ Theory, check this website:
https://www.scienceprofonline.org/microbiology/late-germ-theory-contributions-pasteur-lister-koch-fleming.html

Took many decades for Medicine to accept, and then take into account the germ theory. Spontaneous generation was an explanation even until the early years (in some quarters) of the twentieth-century.

Contemporary rejection of sigma-1 receptor biology, favorably moderated by proprietary ligands (such as blarcamesine) falls right in line with how the recognized medical community, historically, has dealt with new ideas that contravene accepted medical knowledge.

I can think of only one major medical advancement that didn't encounter intial rejection: antibiotics in the middle of the last century. It took many years (and the neccesity of treating infected soldiers in WWII) before Flemming's discovery of penecillin was commercialized. But when available, because nothing else worked at all, modern antibiotics were promptly utilized --- too much, in fact; antibiotic resistant bacteria are now common. Too much of a good thing, too often, too long, at excessive doses.

Which raises the question, when blarcamesine is authorized to treat (or prevent) Parkinson's and/or Alzheimer's, will the drug be over-used, negating or deminishing its efficacies? No indications, so far, that this will happen. Microbes are not involved; only neurons. They don't seem to lose favorable responsiveness to the drug. Unlike microbes, no genetic selection is involved.