Some thoughts beyond the horizon....
Now, this is way out; for cerebral consideration only; not to influence any AVXL buy or sell actions.
Ok, Anavex has filed for a European patent for its chemical, blarcamesine (Anavex 2-73), aimed at various neurodevelopmental diseases and conditions. The one that caught my attention was trisomy-21, Down's syndrome. I could make no sense as to how blarcamesine might resolve the many problems caused by the extra 21st chromosome in the condition.
Could this be the mechanism? Is the company focusing on favorable new prophylaxis during gametogenesis, when eggs and sperms are formed in the gonads (ovaries and testicles) of parents? Might the homeostatic processes induced or modulated by blarcamesine facilitate the autophagic destruction of aberrant gametes, thereby obviating any and all of the aneuploid diseases? Only good, genetically-sound gametes would be produced.
Might blarcamesine prevent the production of gametes with other genetic or biochemical defects? Only good ones would be produced, obviating otherwise consequent genetic diseases.
Now, of course, for this to happen, blarcamesine would have to be consumed during gametogenesis. Not so problematic for males, as sperm production occurs during reproductive years, adolescence through older age. But in females oogenesis, egg production, at least in the earliest stages, begins even before birth, before a future mother is even born.
Therefore, for blarcamesine to facilitate the production of genetically sound ova, it would have to be available in utero. Pregnant mothers would have to consume it.
If that promised the birth of genetically sound babies or grand children, think that mothers would then take the drug?
Formerly, I've proposed that blarcamesine is likely to be universally prescribed starting in patients' forth decade, to obviate the many diseases and conditions of aging. Now, there is the conjecture that humans will be dosed with blarcamesine, in utero, even before birth. What sorts of diseases and conditions might that prevent?
In ten years, will blarcamesine (or, perhaps more likely, Anavex 3-71) be administered to everyone, through all of the years of life, maintaining the health of youth and preventing the diseases of old age? I'm betting that Anavex has preliminary data on all of this, from murine (lab rodent) tests.
