Ardelyx Inc (ARDX)

[HDGabor]

K-

Thx. I got it / understood. I will make more DD re. diarrhea and stool form and frequency changes for my final conclusion.

e.g.: AMPLIFY study

The single adverse event with a placebo-adjusted rate greater than 3% was loose stools/diarrhea at 36%, where most incidents were reported within the first five days of treatment, were transient in nature and the median time to resolution was four days after onset. Notably, only 2.6% of patients in the tenapanor arm discontinued treatment due to loose stools/diarrhea, as compared to 0.8% in the binder arm.

Best,
G

ps.: What is your view about
(i) FGEN (Roxadustat / anemia of chronic kidney disease (CKD), in both non-dialysis-dependent and dialysis-dependent patients) and
(ii) CARA (KORSUVA (CR845/difelikefalin) injection / Chronic kidney disease (CKD) on hemodialysis (HD) with Moderate-to Severe Pruritus)