Anavex Life Sciences Corp (AVXL)

[georgejjl]

Crystalline form of ANAVEX2-73 for the treatment of Alzheimer's disease

Abstract
Composition and method for treatment of Alzheimer's disease that includes ANAVEX2-73. Method of treatment of Alzheimer's disease using pharmaceutical compositions comprising ANAVEX2-73 according to an intermittent dosage regimen.

Inventors: Cecchi; Marco (Louisville, KY)
Applicant:
Name City State Country Type

Anavex Life Sciences Corp.
New York
NY
US
Assignee: ANAVEX LIFE SCIENCES CORP. (New York, NY)

The present disclosure comprises a pharmaceutical composition for the treatment of Alzheimer's disease comprising a therapeutically effective amount of ANAVEX2-73. Particular reference is made to treatment with the composition wherein the Alzheimer's disease is mild-to-moderate, and more particularly wherein the ANAVEX2-73 is characterized by the PXRD pattern shown in FIG. 1 as well as characterized by the thermogravimetric analysis of FIG. 2a or FIG. 2b and characterized by the differential scanning calorimetry analysis of FIG. 3a, 3b, or 3c.

Further included is the pharmaceutical composition wherein the ANAVEX2-73 is characterized by the particle shapes or sizes as depicted in FIG. 4a, FIG. 4b, or FIG. 4c. Specific reference is made to a particle size of between 1 and 50 .mu.m.

Noted therapeutically effective amount of ANAVEX2-73 include about 1 mg to about 60 mg and particularly about 30 mg to about 50 mg. Further noted are therapeutically effective amounts of about 3 mg to about 5 mg, and particularly for intravenous administration. Oral dosage forms are noted.

http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=10,426,754.PN.&OS=PN/10,426,754&RS=PN/10,426,754

Good luck and GOD bless,