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Re: frrol post# 285199

Thursday, 11/26/2020 7:40:21 AM

Thursday, November 26, 2020 7:40:21 AM

Post# of 458942
Hint: What does "% patients in top interval" actually mean?

As I have maintained for some time now, the genetic biomarkers are useful to show an influence based on the target MoA of A2-73. However, the response differences demonstrated so far between Wt. and Variants does not seem to display significant difference to clinically meaningful outcomes.

Actually that is a good thing since concentration is by far most influential for response to A2-73. Consequently, if A2-73 is approved most patients that can tolerate a dose bringing concentration to >= 4 Ng/mL should benefit.
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