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longfellow95

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longfellow95

Re: exwannabe post# 291784

Thursday, 06/25/2020 4:39:15 PM

Thursday, June 25, 2020 4:39:15 PM

Post# of 700889
To say that the reducing of the control arm to 99 has 'little effect' is too sweeping an assertion.
For maximum statistical power, you ideally have 1:1 treatment to control. 2:1 is bad enough; 70:30 weakens things further.
You might end up with a p value of 0.04, when a slightly larger (or less lop-sided) ITT might have given you 0.05...

Alongside that you have the reduction from a planned 348 to 331 courtesy of the partial hold...
More depowering.

Take these two power-reducing factors together (neither of which had been in NWBO's plan) and you effectively have a higher bar to negotiate.
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