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Sunday, June 07, 2020 10:55:06 PM
A later study at Emory (Auld et al 2020) that followed critically ill patients for longer found the mortality rate for was 67/217 = 30.9% vs. 131/217 = 60.4% discharged and 19/217 = 8.8% unresolved.
Another paper (Savel et al 2020) discuss further the widespread media-driven misperceptions of the mortality rate for severe/critical patients and give several further references to look at.
I'm betting we see 40% mortality for severe/critical in the control group. If we then have less than about 25% in the leronlimab group then, we are looking good!
I did a power analysis based on trial size and mortality rate for the control group, asking what size treatment effect would give a p-value of 0.05 with probability 0.8. If mortality rate is 0.4 for the control, we'd need leronlimab to have a mortality rate of 0.2 to get power of 0.8 with 51 patients. With full enrollment, leronlimab would only need to have a mortality rate of 0.345 to be reasonably sure of showing statistical significance.
Here's the full table:
n p_ctrl p_leron
51 0.2 0.023
60 0.2 0.03
75 0.2 0.049
120 0.2 0.099
240 0.2 0.143
390 0.2 0.156
51 0.4 0.19
60 0.4 0.227
75 0.4 0.265
120 0.4 0.298
240 0.4 0.329
390 0.4 0.345
51 0.6 0.426
60 0.6 0.443
75 0.6 0.462
120 0.6 0.494
240 0.6 0.527
390 0.6 0.544
51 0.8 0.643
60 0.8 0.658
75 0.8 0.676
120 0.8 0.707
240 0.8 0.737
390 0.8 0.752
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