Anavex Life Sciences Corp (AVXL)

[sokol]

Yes, Missling describes it as: “ANAVEX®2-73 (blarcamesine) is an orally available, small-molecule activator of the sigma-1 receptor which, data suggest, is pivotal to restoring neural cell homeostasis and promoting neuroplasticity.”
https://www.anavex.com/anavex-life-sciences-issued-new-u-s-patent-for-composition-of-matter-covering-anavex2-73-for-the-treatment-of-alzheimers-disease/

“Living organisms need to maintain homeostasis constantly in order to properly grow, work, and survive. In general, homeostasis is essential for normal cell function, and overall balance.”
https://www.bioexplorer.net/importance-of-homeostatis-examples.html/#Importance_of_Homeostasis

“Homeostasis is the process through which an organism regulates its internal environment, keeping critical parameters within acceptable limits. Aging affects the ability to maintain and restore homeostasis because some of the mechanisms used by the organism are no longer as effective as in a young body.

In many cases the inability to restore homeostasis can affect the body's activities and can result in reduced capabilities and disease....”

https://sciencing.com/aging-affect-ability-restore-homeostasis-22809.html

A simple explanation of what Anavex believes that AVXL 2-73 does is to activate or stimulate the Sigma 1 receptor to attempt to put one’s body back in a state to heal itself. It is a Sigma-1 receptor agonist that restores endoplasmic reticulum mitochondria, which in turn sets off a chain reaction throughout the central nervous system or the body that hopefully repairs the damage resulting from aging or oxidative stress. My simplistic way of thinking tells me that the affect that AVXL 2-73 may have on any particular person in restoring homeostasis and helping that person’s body to heal itself will depend on many factors, including genetic make up, age, severity of the central nervous disease or damage in question, general state of health, diet, environment, physical condition, activity, etc.

It seems to me that the more damage that has been done to one’s body the more difficult it will be for that body to restore homeostasis and heal itself. Each individual is different, and the effect that of restoring homeostasis may vary. I think that if the drug is effective in prolonging life of a person with AD, it may be even more effective if that person is able to make an effort to engage in things that will add to that benefit. Of course, we should not forget too that AVXL 2-73 is a dual agonist - a Muscarinic agonist as well as a sigma agonist. Therefore, the drug may also have health benefits as a Muscarinic agonist such as treating blood pressure.

Lastly, Alzheimer’s News Today says this:

“Anavex 2-73 is a small molecule that activates the sigma-1 receptor, which is known to modulate cellular processes relevant to neurodegeneration. Specifically, Anavex 2-73 is thought to help restore cellular balance by targeting protein misfolding (when proteins fail to fold correctly, into a normal configuration, they do not work as intended), oxidative stress (which damages cells due oxygen molecules with free radicals, or unpaired electrons), mitochondrial dysfunction, inflammation, and cellular stress.

The sigma-1 receptor is a small transmembrane protein, a stress-reducing survival protein, mainly located on the endoplasmic reticulum membrane of cells. This receptor also is present on the surface of some nerve cells and multiple other central nervous system cells and tissues. As sigma-1 receptors are present in various sites, different physiological and pathological processes may be influenced by Anavex 2-73 treatment.

The brain of a person with Alzheimer’s disease has fewer sigma-1 receptors than that of healthy people of the same age. That’s why the activation of these receptors could improve the clinical symptoms of the disease and protect against neurologic changes.”

https://alzheimersnewstoday.com/anavex-2-73/