Cassava Sciences Inc (SAVA)

[mcsharkey]

Well_Ama!_How_do_you_feel_about_the premise_that Altered FilaminA Enables Amyloid Beta-Induced TAU Hyperphosphorylation and Neuroinflammation in Alzheimer's Disease?

Ahh, that's funny every time. Here's a link to that 2017 article where SAVA was still Pain Therapeutics Incorporated (PTI). Only negative I've found on our Texas gusher here was the very recent change in name during March 2019;

My point being PTI 125 has been in development for a long time, and got some links down below to heavy-weight technical papers and government sites reflecting the double-butt load science this pill (PILL, taken with water).

Nuther thing to understand (and all this is above my paygrade):

PTI 125 isn't going to be a CURE for Alzheimers. I don't think anything will for years to come if ever. Kind of like DEATH, no cure foreseen at this time.

Real promise with the battery of PTI drugs to alleviate the total destruction of the victim. Extend the patient's cognitive abilities and quality of life until death. So I think this will be a refilling/recurring prescription. And it has seen global trials.

Alzheimers hit my direct and extended family members. Everybody in the supporting family is hit by this $#1+. Pain Therapeutics was also heavily into the approval of a novel opiod prescription. AND, why FDA disapproved the drug is up for debate. May have been due to the outrage of the epidemic and just a wide-brush ban (my take, but who TH am I?).

The opiod disapproval damn near killed PTI, but their being on this break-through for Alzheimers has kept them GOING (again, my opinion) Link to nuther heavy-weight paper just updated: 02 Oct 2019

And and excerpt: Also in September 2019, the company began a randomized Phase 2b study. This multicenter study will compare 100 or 50 mg PTI-125 to placebo, dosed twice daily for 28 days in 60 participants with mild to moderate AD. The primary endpoint is change in CSF phosphorylated tau, neurofilament light chain, neurogranin, total tau, YKL-40 and Aß42; secondary outcomes include cognitive assessments and plasma biomarkers. This NIH-funded trial will run through April 2020.

Also above my paygrade to tell you what the technical aspect of that means. 4 months remaining in THE TRIAL is my key takeaway.

Last point, this trial is being supported by National Institute of health, and a LINK to their data page.

I'm not betting the farm on SAVA Ama, Hanuman on this board gave me the word on this right before Christmas. I think the clinical coverage, Gov. grants and white papers show there is REAL PROMISE here.

Thanks for getting this far. GLTUA