Anavex Life Sciences Corp (AVXL)

[roygbiv]

Treden,

I saw from a 2010 interview that the Sigma 1 receptor may be the path that allows cancer to spread with speed all over the body

The good and the bad FYI:

Abstract

Exosomes participate in cancer progression and metastasis by transferring bioactive molecules between cancer and various cells in the local and distant microenvironments. Such intercellular cross-talk results in changes in multiple cellular and biological functions in recipient cells. Several hallmarks of cancer have reportedly been impacted by this exosome-mediated cell-to-cell communication, including modulating immune responses, reprogramming stromal cells, remodeling the architecture of the extracellular matrix, or even endowing cancer cells with characteristics of drug resistance. Selectively, loading specific oncogenic molecules into exosomes highlights exosomes as potential diagnostic biomarkers as well as therapeutic targets. In addition, exosome-based drug delivery strategies in preclinical and clinical trials have been shown to dramatically decrease cancer development. In the present review, we summarize the significant aspects of exosomes in cancer development that can provide novel strategies for potential clinical applications.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113508/

Ex Vivo capturing and filtering tumour derived exosomes is about to tip the scale back in favor of the immune system,imo. Early Feasability Studies are approved in combo with Keytruda. GL