Anavex Life Sciences Corp (AVXL)

[TempePhil]

Investor, remembering your discussions of chances of success and blood concentrations...
Regarding blood concentrations, my opinion is Anavex is following blood concentrations closely, because it is closer to the CNS mechanisms, being already in the blood stream, and should be more correlatable to the responses. That is, oral doses have to go into the digestive system first and that may cause variance in the amount of drug that actually gets to the blood stream, depending on the patient. Blood concentration may be eliminating that variable. Does that make sense?

Regarding your guesstimate of chances of success for A2-73, I always appreciated and admired that you were willing to publish a number! My fear has been the low percentage of mouse studies that were also effective in humans. I have to say this PR goes a long way to alleviating those fears. So now we have apparent efficacy in Rett and ALZ. My guesstimate for chances of success go up 15% with this news. Does your guesstimate improve with this PR?