Penny double quoted this 2016 PR from the company:
NEW YORK, NY – November 28, 2016 – Anavex Life Sciences Corp. (“Anavex” or the “Company”) (Nasdaq: AVXL), a clinical-stage biopharmaceutical company developing differentiated therapeutics for the treatment of neurodegenerative and neurodevelopmental diseases including Alzheimer’s disease, other central nervous system (CNS) diseases, pain and various types of cancer, today announced the appointment of three distinguished researchers to its Scientific Advisory Board.
The additional SAB members include:
Tanya Simuni, MD, is AC Nielsen Professor of Neurology and Director, Parkinson’s Disease and Movement Disorders Program at Northwestern University Feinberg School of Medicine, Chicago, Illinois Dr. Simuni earned her Bachelor of Science and medical degrees from Leningrad Medical School, Russia. She completed a neurology residency and clinical neurophysiology fellowship at Temple University, Philadelphia, and a fellowship in movement disorders at the University of Pennsylvania, Philadelphia. She joined the neurology faculty at Northwestern University in 2000. She has built a multidisciplinary Parkinson’s disease center that has been designated a Center of Excellence by the National Parkinson’s Foundation.
Dr. Simuni’s research interests include experimental pharmacology, early diagnosis, non-motor manifestations and surgical management of Parkinson’s disease. As principal or co-investigator of numerous NINDS, MJFF and industry sponsored clinical trials, Dr. Simuni has done extensive research on the treatment of Parkinson’s disease focused on studying potential disease modifying strategies. Dr. Simuni is the principal investigator on the NINDS-funded, multicenter Phase III study of the potential disease modifying agent, isradipine.
Dr. Simuni has received several prestigious awards including the Dixon Foundation Innovation Award, National Parkinson’s Foundation Research Awards, Northwestern Department of Neurology Teacher of the Year Award, and the Northwestern Medical Foundation Award for Excellence in Clinical Leadership. Dr. Simuni dedicates substantial amount of her professional time to teaching and mentoring, and has served as the neurology residency program director at Northwestern.
Daniel Weintraub, MD, Professor of Psychiatry at Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania Dr. Weintraub is professor of psychiatry and neurology at Penn and psychiatrist at the Parkinson’s Disease Research, Education and Clinical Center (PADRECC) at the Philadelphia Veterans Affairs Medical Center. A geriatric psychiatrist, he conducts clinical research in the psychiatric and cognitive complications of Parkinson’s disease, and is author of more than 100 journal articles, reviews, and book chapters.
He completed a NIMH Career Development Award titled “Depression Diagnosis and Treatment in Parkinson Disease”, and has been PI on grants from the VA, Penn, The Michael J. Fox Foundation for Parkinson’s Research, and several industry-sponsored studies, and is current Clinical Core Leader of the Penn Udall Center focused on cognition in Parkinson’s disease.
Dr. Weintraub is Associate Editor for Movement Disorders journal, formerly was on the Executive Committee of the Parkinson Study Group (PSG), has been a member of four Movement Disorder Society (MDS) task forces to revise and make recommendations for the assessment of cognitive and psychiatric symptoms in Parkinson’s disease, and was chair of the Psychiatry Subgroup of the NINDS Common Data Elements (CDE) project.
Kalpana M. Merchant, PhD, President and CSO, TransThera Consulting Co.; Adjunct Professor of Neurology at Northwestern University Feinberg School of Medicine and Adjunct Professor of Biology at Indiana University Purdue University at Indianapolis Dr. Kalpana Merchant has deep expertise in the neurobiology of chronic neurodegenerative and psychiatric disorders. She has nearly 25 years of experience in drug discovery and development with a special emphasis on translational strategies that improve the success rate of drug development.
In March 2014, Kalpana established a life sciences business that provides consultancy services to non-profit institutions and start-up pharmaceutical/ biotechnology companies. She continues to remain engaged in training and mentoring of graduate students, postdoctoral scientists and junior faculty through her academic positions.
Prior to her consulting activities, Kalpana worked in the US pharmaceutical industry as a scientific contributor and in strategic leadership/ management roles. She retired in March 2014 from Eli Lilly and Company where she was the Chief Scientific Officer for Tailored Therapeutics – Neuroscience, accountable for scientific and business strategies to deliver personalized therapies and associated biomarkers for the neuroscience portfolio – from discovery through Phase III.
Kalpana received her PhD in neuropharmacology from the University of Utah. Following a postdoctoral research fellowship at University of Washington, she was appointed Assistant Professor of Psychiatry at the same institution. She was recruited to Eli Lilly in 2003 from Pharmacia Corp., where she had contributed to neuroscience drug discovery research for 10 years.
Kalpana is engaged in the wider scientific community via her service on the National Center for Advancing Translational Sciences (NCATS) Advisory Council and the Cures Acceleration Network Review Board for the National Institutes of Health (NIH), as an advisor to the Michael J Fox Foundation for Parkinson’s Research, membership of The Wellcome Trust Review Board as well as several professional societies.
“We are pleased to welcome Drs. Tanya Simuni, Daniel Weintraub and Kalpana Merchant to Anavex’s Scientific Advisory Board,” stated Christopher U. Missling, PhD, President and Chief Executive Officer of Anavex. “These world-renowned researchers bring extensive experience in neurological diseases to Anavex. I am confident they will make important contributions to our SAB and to the continued development of ANAVEX 2-73 and other compounds in our pipeline for the treatment of neurodegenerative diseases, including Parkinson’s disease.”
___________________________________________________________________________________________________________________ Christopher Missling:
Info on Dr. Kaufmann who will be running the 2-73 Rett Syndrome trial and who is now CMO for Anavex: http://gcbcenter.kennedykrieger.org/staff.jsp ___________________________________________________________________________________________________________________ Emmanuel O (“Tayo”) Fadiran:
Fortunately, Anavex leadership has world wide prominence:
PBS quoting Tanzi (thanks to Kevli33):
But by the time a cognitive assessment picks up on symptoms of Alzheimer's disease and dementia, it's usually already too late for meaningful treatment, said Rudolph Tanzi, professor of neurology at Harvard University who also co-directs the Henry and Allison McCance Center for Brain Health at Massachusetts General Hospital. Two decades before symptoms of Alzheimer's reveal themselves, the brain already is changing.
"We need to know how to treat a person at the right time to stop the disease from becoming symptomatic and leading to brain waste and dementia." Rather than solely relying on less precise assessments, "we need to know how to treat a person at the right time to stop the disease from becoming symptomatic and leading to brain waste and dementia," Tanzi said.
What we should be doing, he said, is encourage more cognitive assessments but also further develop tests and medications to diagnose and treat Alzheimer's before a person loses cognitive abilities.
Tanzi has researched the illness since the early 1980s and was part of the team that discovered the three genes linked to early onset of Alzheimer's disease. In fact, genes may play a bigger role in the development of Alzheimer-linked plaques and tangles in the brain than previously understood, according to recent research.
___________________________________________________________________________________________________________________ Daniel Klamer, MS,PHD,MBA:
From Anavex home page:
Dr Daniel Klamer, Vice President of Business Development and Scientific Strategy of Anavex, has more than 15 years of experience in neuroscience and the orphan disease space, with acquisition, partnering and R&D experience in Europe and the USA. Prior to Anavex he worked at Retrophin and Neurosearch Sweden. At Neurosearch Sweden, Dr Klamer led and evaluated multiple discovery-phase neuropharmacological research products with an emphasis on strategic evaluation of preclinical and clinical development.
Dr. Klamer earned his PhD in Pharmacology at The Sahlgrenska Academy at University of Gothenburg, Sweden, his MBA at Fordham Gabelli School of Business, and his Post-Doctoral training at the Department of Psychiatry, Yale University School of Medicine. In addition, Dr. Klamer holds a position as an Associate Professor at the Department of Pharmacology at The Sahlgrenska Academy at the University of Gothenburg.
See patent section for new info on patents for pain and Alzheimer's treatment protocol. ___________________________________________________________________________________________________________________ Alexandre Vamvakides:
Geneva, Switzerland — January 31, 2007 — Anavex Life Sciences Corp. (OTCBB: AVXL) (the “Company”) announces that it has acquired a portfolio of three patents and one patent application covering drug candidates indented to be further developed through commercialization targeting the areas of neurological diseases and cancer. The patents were assigned by Dr. Alexandre Vamvakides, of Paris, France, who has been appointed as Chief Scientific Officer and member of the Board of Directors.
Under the terms of the acquisition, Anavex is to pay for the development of the compounds by expending not less than $200,000 US per annum. Dr. Vamvakides will lead the development project and will receive 6% royalties on the total net income resulting from successful exploitation of the assigned patents. The Company endeavors to further develop the appropriate compounds utilizing various research facilities worldwide.
Prior to joining Anavex Life Sciences, Dr. Vamvakides has spent 30 years in research focusing on the therapeutic/pharmacological areas of nootropes, anti-neurodegenerative (anti-Alzheimer), antiepileptic, antidepressive, and prototype molecules. During his career, Dr. Vamvakides has been published over 80 times in highly respected Medical/Scientific journals. In the past 30 years, Dr. Vamvakides has pioneered his expertise at the Institut National de la Sante et de la Recherche Medicale (INSERM) in Paris France, at the University of Athens (Greece) as well as at Chropi Pharmaceuticals (Piraeus, Greece), Ciba-Geigy (Basel, Switzerland) and Sanofi (Montpellier, France) for the development of new concepts in the aforementioned therapeutic/pharmacological areas.
2011 "ANAVEX 2-73 attenuated GSK-3beta and Tau hyperphosphorylation in a nontransgenic Alzheimer’s disease model in mice" “It may be that Akt increase and GSK-3beta decrease is a protective mechanism in AD and is restored by mixed sigma-1 and muscarinic agents such as ANAVEX 2-73,” said Dr. Tangui Maurice, PhD, CNRS Research Director, Team II Endogenous Neuroprotection in Neurodegenerative Diseases INSERM, University of Montpellier, one of the poster authors and a member of the Anavex Scientific Advisory Board. “For the very first time, these data show these mixed sigma and muscarinic agents, such as ANAVEX 2-73, block both amyloid-related toxicity and tau protein-related pathology.” https://www.anavex.com/anavex-presents-data-on-potential-dual-utility-of-anavex-2-73-in-both-amyloid-and-tau-pathology/
2013 positive preclinical data Tangui Maurice, PhD, said, “These observations suggest that ANAVEX 2-73 induces a strong neuroprotective effect that is apparently amyloid-beta independent. The data also confirms the efficacy of the mixed muscarinic cholinergic and sigma-1 receptor agonist in a chronic transgenic mouse model of Alzheimer’s. The compound may enable effective brain protection during the most aggressive phase of the disease pathology.” https://www.anavex.com/anavex-announces-positive-data-for-anavex-2-73-in-alzheimers-disease/
ACTC Ops Plan with the initial focus at USC with Dr Paul Aisen's group. (from Talon38 8/18 post) http://grantome.com/grant/NIH/U24-AG057437-01 ___________________________________________________________________________________________________________________ Alani Selvy: New hire noted by kevli33 - no public info from the company as of 04/05/19 https://www.linkedin.com/in/alani-selvey-9117897/?trk=org-employees_mini-profile_title https://www.researchgate.net/profile/Alani_Selvey ___________________________________________________________________________________________________________________ SAB and BOD: *** note to self - break this up into sections ___________________________________________________________________________________________________________________ Harald Hampel:
Research Gate intro:
My objective is to transform Neurology, Psychiatry and Neuroscience embracing Precision Medicine based on Complex Systems Theory using Systems Biology and Neurophysiology, Big Data Science and Biomarker-guided Integrative Disease Modeling (IDA) for improved Detection, Classification and Therapy Development in Neurodegenerative Diseases, such as Alzheimer's disease. Towards this end I have launched the Alzheimer Precision Medicine Initiative (APMI) and the APMI cohort program (APMI-CP). Website Alzheimer Precision Medicine Initiative (APMI): https://www.apmiscience.com/
Revolution of Alzheimer Precision Neurology: Passageway of Systems Biology and Neurophysiology Harald Hampel primary author, posted by nidan7500 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008221/#!po=0.337838 ___________________________________________________________________________________________________________________ Claus van der Velden:
AI
