NorthWest Biotherapeutics Inc (NWBO)

[Umibe5690]

Doc:

Where in the JTM or other studies is it found that the best responding are methylated MES. I may be missing something and hope I can be corrected, but I do not recall anything along the lines that METHYLATED MES responds best to DCVAX. I believe that LL and RP make reference to MES but do not further delineate it. With respect to other molecular groups, it would appear from the chart showing M+/M- major groups which then link the molecular sub groups, that pro-neural is a major component of M- where the JTM article showed, albeit blinded data, that the M+ group responded especially well. The question is why. This seems to be unexpected according to previous UCLA studies. The question is then why?

Wrt to Methylated MES, you may be right but there seemingly is no data to back it up unless I missed something. Then the chart is wrong in stating that M+ is proneural. However, I suppose an argument can be made that methylated MES is relatively insignificant and therefore M+ is predominantly pro neural and Meth MES de minimus. However, it does not appear that LL/RP were excited about a de minimus slice of MES but rather the entire sub group that was responding well to the vaccine. JMHO.