NorthWest Biotherapeutics Inc (NWBO)

[Umibe5690]

Meirluc:

Why would you give up on unmeth? From the pub data, it looks very good. The literature suggests control mOS at 12.7 months. Blended results from the pub show 19.8 months. That is a 7 month delta. Tx delta would be about 9 months. Even using Dr. Bosch's control base point of 14.6 months relating to unmeth(I don't understand why), which is the control mOS for nGBM in general, not just unmeth, the deltas are still impressive. The meth is almost double that of unmeth. No wonder 69 docs wanted to be put down as authors on the pub because this is truly impressive.

I don't know exactly how mesenchymal fits into the M+/M- picture. Mesenchymal, like unmeth, is very aggressive with a much shorter control mOS than M+. However, mesenchymal , like meth, is very heterogenous and mutational, whereas meth has a much longer OS prognosis like pro-neural. There may be some overlap. It also appears that mesenchymal is much less likely to be methylated. M+/M- seem to have different MOA signatures from mesenchymal relating to cellular repair mechanisms whereas mesenchymal appears to be more immunogenic since the tumour micro-environment is less immuno-suppressive thus allowing more time for the immune system to mount an attack with attendant tumour infiltration.

As you know, both Robert Prins and Linda Liau have stated that the vaccine appears to work very well with mesenchymal which comprises anywhere between 30% to 50% of nGBM. Dr. Bosch noted as have other researchers that the vaccine works across all groups--certainly to varying degrees. While I do not believe that unmeth will be more impressive than meth results, both portend to be impressive. JMHO.