NorthWest Biotherapeutics Inc (NWBO)

[Lykiri]

Flipper44,

I'm sorry that I'm late with that whole package of censors
I've been very busy and have not had the time to reply. Now, I did what doctor Marnix Bosch asked to do, looked at the censors!

I THINK I can locate ALL THE CENSORS ON THE GRAPHICS OF ALL PATIENTS still alive at the time of the analysis of the blinded INTERIM DATA.(March 2017)
Censored patients are annotated by a small verticale line.

Note 1: it is my personal view of the figures but I think I am reasonably accurate. I have double checked them 3 times.

Note 2: that wonderful number is 108= patients still alive at the time of the analysis.(March 2017)

Note 3: The information comes from the paper,in particular from the Overall survival curve for patients in the intent-to-treat population and the curves of the ITT population stratified by MGMT gene promoter methylation status. (MGMT Methylated/Unmethylated) https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-018-1507-6
Title: First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma.

Note 4: to get the best result I used my glasses, a ruler, a notebook, a cell phone (mine is a Samsung AVII), a fine elastic that I wind around my cell phone.(it forms a movable line parallel to the y axis when I adjust the graph and scroll) and a bit of common sense.

Note 5: sometimes the censors are so close together that they form a thick censor, I call that a block. In that case you look at the
Methylated/Unmethylated curvers. In most cases a cursor is located on one curve and the other censor on the other curve and both on the same timeline.

Note 6: there are 10 blocks of 2 censors and 1 block of 3 censors.
They are located in the following places on the timeline:
-BLOCK 1 (2 censors): at the beginning of month 18.
-BLOCK 2 (2 censors): at the second half of month 19.
-BLOCK 3 (2 censors) at the second half of month 19
but one step down.
-BLOCK 4 (2 censors): at the first half of month 20.
-BLOCK 5 (2 censors): at the end of month 20.
-BLOCK 6 (2 censors): at the end of month 23.
-BLOCK 7 ( 2 censors with a little space in between and one step down) at the end of month 23.
-BLOCK 8 (2 censors): at the second half of month 25.
-BLOCK 9 (2 censors with a little space in between and one step down) at the end of month 25.
-BLOCK 10 (2 censors): at the end of month 26.
-BLOCK 11 (3 censors!!!): at the beginning of month 29.

Here are some (of many) of MY conclusions:

-I located 11 lost to follow-up patients, all on the left side of the month 18 timeline.

-I believe 2 patients were given surgery in late August or early September 2015. (the MEDIUM time from surgery to randomization was 3.1 months. For these last 2 patients the time from surgery to randomization was possibly 2 weeks below the medium)

-There are 28 censors between the beginning of month 18 and month 23.1 timeline.( NOTE: 23.1 months after surgery is the medium OS (mOS) for the intent-to-treat (ITT) population (n=331) at the time of the analysis (March 2017). These censors are all patients still alive at the moment of the analysis. (March 2017)

-There are 36 censors between month 23.1 and month 36 (End of the graphic). These censors are all patients still alive at the of the time of the analysis. (March 2017)

-Calculation of that wonderful number: 108 – 28 – 36 =44

-That means that every patient who ever crossed the month 36 timeline is still alive at the time of the analysis!

-There are 8 censors between month 23.1 and month 24. These are all patients still alive at the time of the analysis.(March 2017)

-At the time of the analysis(March 2017) 115 patients crossed the border of the month 24 timeline.

-From these 115 patients 44 crossed month 36 timeline and are still alive at the time of the analysis (March 2017). https://www.nwbio.com/dcvax-personalized-dendritic-cell-vaccines/

-From these 115 patients 7 are censored between month 30 timeline and month 36 timeline and are still alive at the time of the analysis.(March 2017)

-From these 115 patients 16 (67-7-44) patients lived at least 30 months but died before the 36 month timeline.

-From these 115 patients 21 (36-8-7) are censored between month 24 and month 30 and are still alive at the time of the analysis. (March 2017)

-From these 115 patients 27 (115-44-7-16-21) patients lived at least 24 months but died before the 30 month timeline.

-36(28+8) patients are censored between the beginning of month 18 and month 24 timeline and are still alive at the time of the analysis

-OVERVIEW EVERY TWO CONSECUTIVE MONTHS:
-15 patients are censored between month 18 and month 20 and are still alive at the time of the analysis.
- 9 patients are censored between month 20 and month 22 and are still alive at the time of the analysis.
-12 patients are censored between month 22 and month 24 and are still alive at the time of the analysis.
-10 patients are censored between month 24 and month 26 and are still alive at the time of the analysis.
-3 patients are censored between month 26 and month 28 and are still alive at the time of the analysis.
-8 patients are censored between month 28 and month 30 and are still alive at the time of the analysis.
-4 patients are censored between month 30 and month 32 and are still alive at the time of the analysis.
-2 patients are censored between month 32 and month 34 and are still alive at the time of the analysis.
-1 patients is censored between month 34 and month 36 and is still alive at the time of the analysis.

-With these figures in mind, the death event between month 24 and 26 and the 10 patients censored between month 24 and 26, I believe there is a population of extended survivors (n=100) that have lived at least 26 months with mOS of 40.5 months at the time of the analysis (March 2017).

-46 patients are censored between month 18 and month 26 and are still alive at the time of the analysis.

-I believe that all these figures are indicative of a long tail.

-I am convinced that all patients still alive are very,very, very thankful!!!

-I have tried to do my best.and I wish everyone good luck to find 1 more censor. Remember, the outcome must always be that wonderful number 108!!!!!

-I advise everyone to view the presentation of Dr. Marnix Bosch. (ASCO 2018) In my opinion, the last second of his presentation tells the whole story! https://www.nwbio.com/dcvax-personalized-dendritic-cell-vaccines/
-Best wishes