Homeostasis Always Has a Feedback Loop
Important information, to understand the (here) commonly tossed into the air phrase “homeostasis.”
Yes, Anavex 2-73 restores neuron homeostasis, providing restoration of full, normal function. But an understanding of the homeostatic process will give a much clearer understanding of how Anavex 2-73 is so different from (and more successful than) other Alzheimer’s treatments.
It’s the “feedback” process. Within all cells, hundreds of chemical reaction sequences are in process. For example, glucose diffuses in from the serum (blood). It gets transported to the mitochondrion, where the molecule gets passed along a complex sequence of enzymes, each of which pulls the (at the start) glucose apart, making new molecules. It’s called cellular respiration, essential for the extraction of the energy in the glucose molecule to power all the other chemical reactions in the cell.
After being processed through the many sequential reactions in the mitochondrion — each mediated, controlled by specific, unique protein enzymes — 36 to 38 adenosine triphosphate (ATP) molecules are produced. Carbon dioxide and some water molecules are produced as waste. The new ATPs go off into the cell and power all of its chemical reactions.
So, where’s the “homeostasis” in all of this? If it’s so crucial, how so? What’s this “feedback” thing?
If the all of the proper enzymes are floating around in the cell, at useful concentrations, the cell has to function properly and normally. The laws of physics and chemistry are at play. But enzymes are complicated, carefully-folded proteins. They wear out, or get bent out of shape and no longer function. That’s where homeostasis comes into play, the feedback mechanism.
The cell constantly monitors reactions and enzymes. When reactions are too slow, for lack of a controlling enzyme, there is feedback, where the cell automatically reads the feedback signal and starts to produce (in the ribosome and endoplasmic reticulum) more of the needed enzyme.
If there is enough of the enzyme, the process is turned off. When needed, it’s turned back on.
In Alzheimer’s and most other central nervous system diseases, the feedback mechanism no longer works. The cell may signal that it needs more of a particular enzyme (say, the enzyme to clear beta-amyloid wastes, the ones that cause Alzheimer’s symptoms). But if the cell can’t produce the now called-for enzyme, when the feedback, homeostasis process fails, disease ensues.
Anavex 2-73 re-connects endoplasmic reticula with the associated mitochondria. With this physically close relationship, sufficient ATP is produced and transferred to the ER, allowing normal production of required, signaled-for enzymes in the feedback, homeostasis process. Normal cell function is restored.
No other company has a drug that can do this for the treatment of Alzheimer’s and the other targeted CNS diseases. It belongs to Anavex Life Sciences Corp — Anavex 2-73.
