Amarin Corp Plc (AMRN)

[jessellivermore]

Babr...

Does EPA's anti inflammatory actions increase the risks of infections...

Great question...We all know what happens in AIDs and we know about the "Bubble Boy"...

I don't know the answer...This will be one of more than the thirty data points looked at in R-I...

My guess is the effect is going to be fairly small...

First an anecdotal story..About a year and a half ago I was stung by a hornet on the palmar side of my left middle finger (right through my golf glove) at the middle phalangial joint...By the next day my finger and hand blew up despite the fact I was elevating my hand. The next day my hand was so swollen I knew this was a serious infection and I headed into Florida Hospital...I was seen in the ER, had blood drawn including cultures and was treated with IV Vancomycin..(MDs in the crowd know what that means)...I returned for twice a days for three more days...And the swelling went down...Of note on my intitial admission my CRP was over 9.

I have had no similar episodes..

The EPA/AA ratios in the R-I are dosed to match the treated arm in JELIS..In JELIS there was no concern over higher infection rates. Steroids pretty much destroy the COX and LOX receptors and end all functions both good and bad...EPA actually promotes inflammation, just not as much as AA.

":>) JL