Amarin Corp Plc (AMRN)

[Whalatane]

Ralphey re your expectation with diabetics high TG/low HDL

consider the following

https://www.ncbi.nlm.nih.gov/pubmed/28122840

NOTE High TG and low HDL level was associated with CHD risk in participants with an LDL-C level of =130 mg/dL, but this was not observed in those participants with lower LDL-C levels

benefit seen when LDL was over 130 ...in JELIS median was 178 !
In R-IT median LDL is likely to be between 70-80 .....so you may not see the benefit you are expecting .
Biggest benefit IMHO is likely with those patients with recent PCI's / CABG's .

Re your idea of including a statin naive arm. Probably 60% of those in R-IT will be either stented or CABG . How many of these patients do you really think are now not on Statin therapy ?
Most studies show that for those who consider themselves Statin intolerant ...can adjust to some Statin dose by starting out with very low dose every second day on a Statin like Livalo and gradually working up.
Bet anyone having been thru a PCI or CABG will really try and comply with their Cardiologist's instructions re Statin dose....even if it means putting up with some leg cramps .

JMO
Kiwi