Amarin Corp Plc (AMRN)

[ralphey]

Family doc .... The lowering of trigs is not substantial - yes it does lower but not significantly - there seems to be rebound - one patient with MI while on, no proof that OTC does not work as well - one patient with CVA while on .... having said all that as previously indicated I do think we will get some results in diabetics with high trigs low hdl - also I am not only going on numbers alone I do think the general reduction of inflammation has potential

The real tragedy is poor study design. AMRN could have had statin intolerant branch - likelihood of success in statin naive patients would have been much greater . Treating remnant lipids is less likely to show success if effects of med are marginal. They may have eclipsed an entire market based on this flaw of design - but being but a humble rural family physician such complexities lie far beyond my cognitive capabilities

Individual cases do not a science make - yet please note - I posted about my individual experience with substitution of OTC by cardiologists and patients - and this was confirmed somewhat serendipitously by AMRN itself and their law suit.

Does my experience with the above patients make a science... hardly ... however a true scientist, a true analyst would have sat back and examined the information without anger without fear ... and tucked the knowledge away to see if more came forth to confirm the possibility

Will my patient experience go the same way as the confirmed OTC debacle that AMRN is now trying fight - I dont know I simply communicated my reality.

The real issue that AMRN will face if there is failure of REDUCE IT - is the possibility of law suits by investors for study design failure as noted above