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Re: dmlcento post# 112771

Thursday, 08/24/2017 10:14:21 AM

Thursday, August 24, 2017 10:14:21 AM

Post# of 425923
Unfortunately many of the patients that I had prescribed vascepa for were denied by insurance - ultimately about 50% or less got it -
you question asks ? DO I have a study that would replace REDUCE IT - no - no scientific study to replace REDUCE IT - I hardly think if I had 80 million odd dollars laying around I would spend it on such - but I have isolated cases - One person with MI -

One person with artificial heart valve - numerous strokes despite being on coumadin, despite being at therapeutic levels at time of stroke - extensive w/u for hypercoag state ( ie antithrombin III, lupus anticoagulant factor V leydig etc etc - all negative) w/u for structural abnormality in cerebral vasculature negative) no cause found ... remember FDA concerns about clotting ? - yea - was that the cause - I dont know ....

and then the odd cases where it seem to have lost its effect on trig levels over time as I revealed yesterday. In general I see about a 25% reduction - however, that level of reduction can easily be obtained with dietary change ( as opposed to ldl where dietary manipulation has little benefit).

Of course the easy answer to your ? is what have you seen that is positive - ie how would anyone know that they were going to have a heart attack and vascepa stopped it ? You do see how illogical such a statement would appear to an outside observer?

Thats my whole point - we cant know until the study is completed - thus to have unbridled enthusiasm that it will work is illogical to me - I am simply saying there is a possibility that this is not going to be as successful as we think.

Again my position is I believe it will have limited success mainly in subsets ie diabetics with high trigs and low HDL
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