Anavex Life Sciences Corp (AVXL)

[nidan7500]

Do you recall reading WHY any AD drug did not work, failed trials? I don't. We are told end points not achieved b/c patients did not respond...blah, blah..some died...move on, do not collect $$. Das Ende.

The difference of course is Dr. M. has said WHY A2-73 works in great detail and also why the same thesis applies in other CNS diseases. Others have said..."Well , the plaque thing did not work out...again"...99.4% of the time over the past 3+ decades, definitely not good. Trials and animal pre-clinical results do not contradict the "Why it works" story. So far so good. So, if one applied that logic to the "plaque thesis", only a fool would expect passing future trial results.

I would be among those who say that long periods of silence by Dr. M. are worrying. But, I take some comfort that no claims of proof the CNS cell Homeostasis theory is wrong have been made. Which seemingly would be easy enough to do, as I am certain Dr. M has studied before he went there. He says the science is there and most of the rest of the Pharma world is basically still saying the earth is flat.

I do agree with another posters suggestion here on why the silence on ANYTHING of consequence from AVXL. He suggests and I agree that AVXL are in final discussions/planning w/FDA/DC/2nd parties to begin fast-track/BTD trials and any hint/public statements would step on the process and break the trust. Re-watching the last Dr. M. show observing the throw away BIIB MS testing comment and other dismissive gestures helped me to see this point. Bottom line for me is until the BTD story is proven wrong I am a believer.