Skye Bioscience Inc (SKYE)

[Vinpat]

All FDA approved drugs will be synthetic and there are similar side effects from the plant. When taken orally, it's metabolized by the liver and that's where the problems occur with efficacy and side effects. Everyone reacts differently so there's a high likelihood of failure in clinical trials.

A suppository is a last resort but there is enough of a market for it and it bypasses the liver. It's the least expensive and most reliable method to get approval.