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Skye Bioscience Inc (SKYE) RSS Feed

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THCVHSCloseOpen

Our lead candidate, THCVHS, a proprietary prodrug of tetrahydrocannabinol (THC), is a topical formulation under development for the treatment of glaucoma and ocular hypertension (OHT).

Previous US government studies in humans discovered that THC was able to reduce intraocular pressure (IOP), which is in part responsible for the crush-like injury to the cells of the optic nerve that can eventually result in blindness. Additional preclinical studies have shown the potential for THC to also provide neuroprotective benefit, which may be especially important to patients with glaucoma who are experiencing disease progression with normal IOP levels.

One of the major drawbacks of previous studies of the use of THC for glaucoma was that they relied on inhalation or ingestion of THC. These systemic routes of drug administration cause negative side effects like psychotropic effects and potentially decreasing blood pressure , which resulted in the American Academy of Opthamology determining that the adverse effects of systemic cannabis administration/consumption outweighed its therapeutic benefit.

At Skye Bioscience, we chemically modify THC to create a unique synthetic molecule with the intent to safely realize the known positive effects of THC. Our molecule enables enhanced local delivery in the eye, reduced systemic side effects, and the potential for neuroprotection for the treatment of ocular diseases.

THCVHS for the treatment of glaucoma

Glaucoma is a group of eye diseases that can cause vision loss and blindness by damaging a nerve in the back of the eye called the optic nerve. Damage to the optic nerve is caused by increased intraocular pressure (IOP) due to improper drainage and/or overproduction of fluid in the eye.

According to the American Academy of Ophthalmology, glaucoma affects over 75million people worldwide and is the leading cause of blindness in adults aged 60 and older.

Current therapies can lower IOP but progressive tolerance requires switching or combining drugs. They do NOT provide neuroprotective capabilities.

 

In preclinical studies, Skye’s THCVHS demonstrated the potential to significantly reduce intraocular pressure (IOP) – exceeding the capabilities of leading commercialized drugs in the current glaucoma market.

Additionally, it has been demonstrated:

  • Skye’s THCVHS formulation enables it to better enter various compartments of the eye vs natural THC
    Its formulation lowers IOP better than leading current prescribed drugs in animal models
    THCVHS or its metabolite (THC) is not detectable in the plasma or brain tissue after topical administration to the eye
    THC in an ex vivo model demonstrated lowering of IOP and the reduction of biomarkers related to fibrosis, inflammation, and vasodilation, supporting a multimodal mechanism of action.
 

CBDVHS
CBDVHS is a proprietary analog of cannabidiol (CBD) that has demonstrated biological activity that is both pharmacologically and therapeutically distinct from CBD in various preclinical modelsPreliminary data suggest potential analgesic, anti-inflammatory, anti-fibrotic, anti-infective and anti-seizure activity of CBDVHS opening the door to multiple therapeutic applications. We are actively conducting additional preclinical studies to help determine and prioritize a well we defined development plan for CBDVHS.


Team

 

Our Mission

We develop novel and proprietary classes of synthetic molecules through the modification of naturally derived systems.

Our Vision

Shifting the solutions paradigm on a effective treatment of diseases through the development of novel neuroprotective solutions.

Our Values

Science First
The foundation of Skye Bioscience.

Revolutionary Solutions
Solving unmet needs of diseases with limited treatment offerings.

Product-led
Commercial differentiated applications to provide therapeutic benefits.

Impact driven
Change makers. Platform solutions that can extend beyond a single disease.

Management

Punt Dhillon

CEO

Mr. Dhillon was the co-founder, CEO, and director of OncoSec Medical Inc., a leading biopharmaceutical company developing cancer immunotherapies for the treatment of solid tumors.

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Tu Diep,MSc

Senior Vice President, Development 

Mr. Diep brings more than 15 years of scientific and clinical research experience to Skye Bioscience. Prior to joining Skye, Mr. Diep was at Protox Therapeutics Inc.

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Richard Janney 

Principal Accounting Officer 

Richard has more than 30 years of business experience and served as a Vice President to CFO on multiple companies in a wide range of industries both public