Skye Bioscience Inc (SKYE)

[cjarmstrong]

The article was about synthetic cannabinoids. I read an article where Dr. Ethan Russo (neurologist, psychopharmacology researcher, former Senior Medical Advisor to GW) talked about dronabinol:

"THC-only pills have been available by prescription in the U.S. since the 1980s under the brand name Marinol, which is synthetically produced THC dissolved in sesame seed oil. Russo says people often discontinue Marinol due to negative side effects, which he believes come partly from the absence of marijuana’s other cannabinoids. “They get anxious, dysphoric [and] scattered,” he says. “It interferes with their ability to function.” The U.S. Food and Drug Administration in 2016 approved another oral THC formulation called Syndros: pure, synthetically produced THC dissolved in alcohol... “THC alone is a lousy drug. It is a very poor therapeutic index,” Russo says. “I’ll tell you right now, [Syndros] won’t be exciting or gain a lot of traction either.”"

Would a suppository be any different? Nemus also didn't mention that for CINV dronabinol/nabilone are approved as last line treatment options meaning they are only prescribed when patients don't respond to conventional antiemetics.