Anavex Life Sciences Corp (AVXL)

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I believe the first testing of S1r was in vitro, in a dish. Neurons were dosed with 2-73, and tested with chemicals that cause damage, at this level 2-73 showed neural protective qualities. Then after not failing they moved onto murine models. After publishing their work on mice; moved onto an a phase 1 trial, developing a range for maximum tolerated doses in health volunteers. The phase 1 trial also established PK/PD data. All the way along the company has tried to fail the compound as quickly as possible, but so far so good.