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Re: sudnwealth post# 92446

Sunday, 02/19/2017 11:38:38 PM

Sunday, February 19, 2017 11:38:38 PM

Post# of 461262
Well to be honest, I'm not sure it was a case of excellent investigative discovery since I actually put the link to the quote in my original post so people could read the full article without me copying and pasting the entire article.

Here is an example of how that is done.

"Researchers from FAU, in collaboration with The Scripps Research Institute, have opened up the possibilities for rapid drug screens to treat seizures in the near future by using a microscopic nematode worm.

"The study, “Modulating Behavior in C.elegans Using Electroshock and Antiepileptic Drugs,” just published in PLOS One (http://dx.plos.org/10.1371/journal.pone.0163786), has led the researchers to build on the current animal models for inducing seizures via electroconvulsion in the genetically modifiable C.elegans that only has 302 brain cells called neurons. C.elegans has been used for decades as a model animal to study the genetic and molecular underpinnings of neurological disorders through a number of techniques including bio imaging, electrophysiology and behavior."

http://www.fau.edu/newsdesk/articles/epilepsy-worm-study.php

I assume the implication was that it's silly to use snails as preclinical evidence for drug discovery. Perhaps mice would be preferable. I believe that is where the preclinical work was done on A2-73 correct?

What is the success ratio for human drugs for Alzheimer's based on those mouse models by the way?

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