NorthWest Biotherapeutics Inc (NWBO)

[Doktornolittle]

AVII: Your expert is speaking English for us, but I think there is still some translation needed, provided below:

10:36) I have absolutely no idea what the data is showing for the DCVax-L trial, but I am going to proceed here to convince you that the data is bad. Please ignore the fact that I will show you that going after 1 antigen, my favorite approach, turned out to be disastrous while going after 6 antigens that are not even neo-antigens does seem to have some efficacy. So clearly going after scores of antigens, including neo-antigens will fail miserably.

11:00) There is a very good reason that NWBO cannot talk about the data (even if they know the data, which they don't). There is an increasing concern about disclosing data.

11:05) We all know that trial sponsors have access to unblinded data even before their DMC's and would publicize that unblinded data if it was good.

14:10) Celldex screened out 80% of patients for enrollment.

14:20) I was absolutely shocked that a trial based on a single antigen that is not even a neo-antigen failed miserably. This announcement was the worst day of the year for me. And I am considered a fgn expert in this field.

14:58) First Celldex reports that 26 of 32 progressed patients show none of the target antigen in the recurrent GBM. Then, beyond belief, they initiate a phase 2 for recurrent GBM "ReAct" using the same self antigen with no screening for patients that still show the antigen, and report the best results ever reported for GBM. Even more amazingly, instead of calling these guys out on what is obviously a repeat scam, "Re-Scam", I am very excited about these results, as are many charities.

????) That's it. He never actually gives any reason whatsoever to suspect that DCVax-L will not work other than the fact that the sponsor has not bragged about the results before the data is unblinded.

AND THIS IS ONE OF THE MOST RESPECTED MEN IN THE FIELD
HINT HINT!