NorthWest Biotherapeutics Inc (NWBO)

[Doktornolittle]

"MDSCs, lactate, and a low pH in the tumor microenvironment inhibit the function of natural killer (NK) cells and T lymphocytes, hence allowing for disease progression."

From the next to the last paper that you linked.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881600/

It doesn't make any sense to me that low pH would be specificly suppressive to the immune system. Tumors grow fast and with less vasularization than normal tissue. For that reason they tend to produce more CO2 than they can efficiently get rid of. That would likely be the single largest factor determining pH in the local environment. A local low pH then would be a clue, among others, that a malignancy is present. Detecting such clues is a key function of the immune system.

For that reason, I find it surprising that a low pH is talked about as immunosuppresive. A low pH is suppressive to all cells, not just immune system components. I think that is overlooked here, and it is something pretty basic to overlook. So... is this article biased? Are all the articles biased?

Probably not, but it makes me wonder a little.

Certainly you have done well to collect all these articles, and I will examine them further.

Re DCVax-L expectations: At this point I would be happy with 6 months PFS for the methylated mesenchymals. 6 months for all mesenchymals would be even better... with the complement to the methylated being a challenge that would hopefully be quickly overcome. If the LL presentation data was as meaningfull as LL conveyed, then I think the latter of these will be found, possibly soon. If not... as many ar arguing, then us longs are in trouble soon, at least for a while.