NorthWest Biotherapeutics Inc (NWBO): The tumor microenvironment is heavily im...

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Re: Doktornolittle post# 59157

Saturday, 04/16/2016 4:17:30 PM

Saturday, April 16, 2016 4:17:30 PM

The tumor microenvironment is heavily immunosuppressive. In the case of GBM then M2's, Tregs, MDSCs are all a problem as is lactate http://www.ncbi.nlm.nih.gov/pubmed/21636707 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786818/ http://www.ncbi.nlm.nih.gov/pubmed/23817426 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881600/ https://www.researchgate.net/publication/292576724_M1_Macrophages_Demonstrate_a_Superior_Phagocytic_Response_Against_Glioblastoma_Multiforme_Following_Anti-CD47_Treatment and so on. If anyone thinks DCVax-L is going to be enough then good luck with that.*

*Not that I think it does much anyway

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