Sunday, April 10, 2016 11:13:50 PM
The really funny part to me about all of this is that Pyrrhonian put up a chart a while back demonstrating that DC vaccine plus checkpoint inhibitors was better than either alone. He was trying to show that DCs by themselves are not all that effective. Now, do BMY or MRK want just any DC vaccine or one that is as close as any at being proven very effective in at least close to half of all patients and perhaps many more. Imagine if the right combo of surgery (tumor load reduction), chemo/radiation (leukopenia and damaged remaining cancer cells), antiviral vaccines (improved DC migration) , IL-2 blockers (Tregs down regulation during lymphocyte buildup prior to and during immune response from DC treatment) and or DC treatment (immune response upregulator) plus Temodar (alternating immune upregulation with down regulation of cancer cell repair) and or antibodies (down regulation of immune response suppressors PD-1/PD-L1) were to be given in the right sequence. That might lead to all patients living longer right? Perhaps you can explain this to Adam in terms of how grapefruit juice works so that these concepts no longer fail to make sense to him like they do with Direct. Then again, maybe we should ask him to look up the definition of "synergy" and report back. Best wishes.
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