NorthWest Biotherapeutics Inc (NWBO)

[Doc logic]

Ready4bluesky,

I know this may seem strange to you but do you remember the "grapefruit juice" comment by Adam? That was in response to a post by me over on Seeking Alpha. The reason I mention this is that I had postulated that NWBO might be pushing Direct to the forefront while the public focus stayed on L. If this is true, then all the manufacturing capacity needs to be ready for Direct as much and probably more than for L. If they are tweaking the automated manufacturing process for Direct to improve the concentration of DC subset cells associated with survival, then you would certainly want to go to the finish line with L to buy time unless the regulators stop the L trial early for some reason. The current delay could be for many reasons but manufacturing processes for something that may be expected to have a seriously high demand would certainly be an issue with the regulators.

The PIM approval process requires proof of ability to manufacture at commercial quantities (scalability) be given. Getting through the hurdles takes time and a great deal of money. Those who have their eyes on the manufacturing sites and job positions being filled probably have the best picture of what is going on with NWBO right now from a retail investor perspective.

Some on this message board have speculated that the news about Direct will not be extremely encouraging and that is why NWBO is witholding it. I think the opposite is true and that Mr. Woodford knows about this and the reason for the L screening hold as well. I believe the paper being worked on with regard to Direct and planned for publication in a peer reviewed professional journal will have data and observations that could significantly change the investment climate surrounding NWBO right now. I also believe that the screening hold lines up well with trial patient and long term investor interests one way or another.