NorthWest Biotherapeutics Inc (NWBO)

[Pyrrhonian]

AVII, thx for your reply on steroid use and ePD. True early progressive disease certainly results in the need for such much more often than psPD, although the latter isn't entirely removed from that need. A psPD lesion will much more often not present with clinical symptoms. And so the requirement to be off steroids for 14 days prior to randomization would remove some number of ePD by itself. If the split is 70/30 let's say, and 15% of ePD need steroids and the rest of each do not, the split shifts to 60/40, etc. Makes sense.

On whether or not patients that passed initial screening in the DCVax L P3 but then failed at baseline 1 because the tumor bed of their fully resected mass showed 1cm of something that might be growth and was >/= 1.25 cm at baseline 2 (10 weeks later)--OR was 85% resected and the residual "grew" 25% from there to let's say .3 cm, to then fail again at baseline 2, 10 weeks later because the suspected mass "grew" another 33% to .4 cm, is not only conceivable but a very real occurrence for a % of these patients:

http://www.ajnr.org/content/32/11/1978.full

10 weeks is just not enough time.

And so I strongly suspect some or all of the long tail survivors of the so called "double rapid progressors" are in fact psPD.