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Wednesday, February 17, 2016 7:50:47 AM
First, I don't see how there can be a single pseudoprogressor in the rapid double progressor group of patients. No way.
You recognize that psPD can occur any time in the first 6 months after primary therapy.
I would imagine that the apparent progression is not immediate, but rather follows some ramp (I am guessing here, but I don't think one day a patient has zero radiographic signs and the next day he is at the max.)
Do you not think that under the above scenario a patient might start showing signs of psPD shortly before Baseline (enough to remove him from the main arm) and then continue to show further signs of progression at Baseline 2?.
I think that's a possibility.
This might be a good time to point out the difference betwwen the Abstract and the Poster. The Abstract contains different patients than those in the ePD group on the poster (none alive in the abstract, one alive in the poster, an extra patient in the Poster).
Where then, are you suggesting these "sickest of the sick" went if not into the Information Arm? Do you think there is another group of truly rapid progressors (beyond being a double rapid progressor) that were turned away completely and refused treatment?
Um, yes. I am suggesting that there may be a few. Do you think EVERY SINGLE patient who had a leuk procedure went on to receive DCVax no matter what the course of his disease?
Remember, even the expanded access trial requires a KPS score of 70 or above. The "sickest of the sick" might have a KPS score below 70. Such a patient might not have received DCVax in the Info Arm. Remember this patients account?
My dad will be finishing his 6th round of monthly Temodar at the end of Sept. We are going for compassionate use of the DCvacine after that. The only problem is that they have to taper off his steroids before they can remove his white blood cells for the procedure as well as during the vaccine injections. He has GBMIV dx in Jan 2011. surgery in Jan as well but was severely set back by the seizure that announced his tumor. He has not responded well to cutting back on the decadron. I am really worried that he won't be able to handle being off decadron.
It is situations like that I am referring to. They are exceptions rather than the rule, yes. My point is that the comparator trials would have included him in the analysis and the DCVax Info Arm analysis may have not included patients like this (they only included patients who actually recv'd DCVax)..
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