NorthWest Biotherapeutics Inc (NWBO)

[Smokey21]

My understanding is that the first interim would be at 60 percent of the total events (progression or death)for the endpoint (248 x .60 = 149), second IA at 80 percent, and final readout at 248 events. So, if there are 348 total enrolled, that would mean there will be a total of 116 patients in the placebo group. So, if every placebo patient evented, that still leaves 33 patients that need to event in addition to the 116 before getting to the first IA. My interpretatIon of what Linda said is that the treatment group is not eventing as much and as a result we cannot get to that first IA. I interpret that to be a good indication that the treatment group PFS is higher than expected. This is all of course IMHO.