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[$heff]

Biotech Catalyst-Rich 6-12 mos. ahead.:
Upcoming important and potentially value driving events for participating
companies include:

-$ALNY (OP) Patisiran Ph II OLE 18-mos. update at
ATTR in Nov'15;

-$BMRN (OP) & SRPT (MP) DMD AdCom panels in late-
Nov. followed by PDUFA's on 12/27 and 02/29/16, respectively;
$BMRN
(OP) 12-mos. Ph I/II/III Batten’s disease data in 4Q/early ’16;

-$CDTX (OP)..Ph I CD101 data in 4Q;

-$FATE (OP) ZX008 additional data in Dec'15;

-$RPTP (OP) Ph II/III Huntington's data in 4Q;

-$ZFGN (OP) Ph II 6-mos.interim severe obesity data by YE15/early ’16 & Ph III 6-mos. PWS data in 1Q16;

-$FATE Prohema PUMA study data by YE;

-$FOLD (OP) EU CHMP
opinion by YE15/early '16, Ph III Zorblisa data in 1H16;

-$PRQR (OP) QR-010 NPD data by YE15, Ph Ib data by 4Q/1Q16;

-$QURE Ph I/II Interim data in 4Q.