Avid Bioservices Inc (CDMO)

[biopharm]

7) C1q binds PS and look who was involved? : ) keep digging deeper

C1q binds phosphatidylserine and likely acts as a multiligand-bridging molecule in apoptotic cell recognition

Helena Paidassi

Tacnet-Delorme P, Garlatti V, Darnault C, Ghebrehiwet B, Gaboriaud C, Arlaud GJ, Frachet P

http://www.ncbi.nlm.nih.gov/pubmed/16617157

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Tobacco and e-cigarette products initiate Kupffer cell inflammatory responses.

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We observed a robust inflammatory response, oxidative stress production and cytokine release after Kupffer cells were exposed to tobacco or e-cigarette extracts. We also observed a marginal decrease in cell viability coupled with a significant decrease in cell density. In general, this was not a function of the extract formulation (e.g. tobacco vs. e-cigarette products or the formulation of the cigarette product). These results indicate that Kupffer cells are responsive to classical cardiovascular risk factors and that an inflammatory response is initiated that may pass into the general systemic circulation.

http://www.ncbi.nlm.nih.gov/pubmed/26072673