NorthWest Biotherapeutics Inc (NWBO)

[flipper44]

Hi Gnawks, it looks like evaluate already gave you the posts demonstrating 2-3 grams of tumor tissue is needed for the trials.

For expanded access, hospital exemption and compassionate use, I suspect the amount might range down to less than a gram.

IMHO, where resection is not feasible, but L may still be helpful, core needle or vacuum assisted biopsy will be used in the future to obtain enough tissue to provide initial treatment.

note: Someone recently raised a concern that the process to obtain a vaccine might take considerably longer than 8 days; however that was years ago. At this time, processing has been reduced to 8 days. The time in trials for standard of care plus Temador plus radiation is the only bottleneck holding up therapy, and I suspect we will hear about various options reducing this time delay as hospital exemption moves forward.

In the United States, the expanded access group may provide a gateway to options not formally using the Stupps protocol, because some patients in that group were only included for treatment after their tumors started to regrow, and yet their first tumor samples were previously preserved and are now used upon progression without the Stupps protocol delay.

In short, as Stupps himself would applaud, treatment protocol should become more patient specific as time goes on.