NorthWest Biotherapeutics Inc (NWBO)

[gnawkz]

Thanks Flip. I can't contribute much on the science side of things except to share what I hear or see.

I am not sure if any of you can help (Evaluate?), but I recall reading through all of the iHub posts that there were several about what the minimum amount of tumor was necessary in-order for Cognate to create DCVax-L.

Maybe my memory is faulty, but I think one of the poster said that the minimum tumor size was a Sugar Cube (~4 grams) and another said it is now just 2 grams. That is a 50% reduction in raw material input. This implies that throughput yields have improved substantially due to all the process upgrades that Cognate has created/discovered. Essentially, they are able to produce the same amount of DCVax-L vaccine with 50% less raw materials.

The other side of the coin is that, NWBO realized they don't need as much vaccines for each treatment. Thus they started to collect less raw material for manufacturing finished goods, but I find that to be highly doubtful considering dosing studies should have been completed much earlier.

Just not sure if the above are facts or something I read somewhere else. Anyway, I believe in Cognate's ability to manufacture great treatments.