NorthWest Biotherapeutics Inc (NWBO)

[beachlifeisfun]

Flipper,

That is a very informative post. I truly appreciate all of your (and Steven's) DD that you willingly share with this board. IMHO most Big Pharma companies have stayed away from NWBO because of what happened to DNDN...the tech definitely works, but it still seems somewhat gold-plated with very little profit margin.

I would debunk this by the obvious amount of $$ that NWBO has invested in the manufacturing process...but more importantly I would suggest that Direct will likely be much less expensive than DCVax-L. Both have already been shown to be outright efficacious, but I think that Direct's profit margin will be considerably higher as it should be much less expensive to make (tumor preservation, transport, storage, lysate preparation, etc all goes away)...AND it should also be more potent because *debated hotly here* each injected tumor represents a new vaccine, thus minimizing the tumor's ability to "hide" from the active immune system.

Additionally, while not explicitly identified, the lysate process for -L is pretty brutal...it most assuredly destroys all of the tertiary and quaternary structure of the antigen(s), and likely some of the more fragile primary and secondary structure as well...Direct will allow phagocytosis in situ, meaning much of these structures will be preserved...again likely making Direct a more potent treatment.

Ultimately Big Pharma have been chasing the profit margin, which is why they overlooked the DC-lysate tech, but NWBO seem to be on a mission to do some serious damage to the disease itself (here, here, it's about time) despite the lower profit margin...and in doing so learned the trick, through Direct, to making the therapy very profitable while still effectively treating/curing a good chunk of cancer types.