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Friday, November 14, 2014 8:32:33 PM
I have to thank you for your opinions on the AEMD board. You got me doing some internet research.
Here it goes :
- Blood volume :It is unlikely to be 5000 cvs as when the treatment was started, the doc. was already very sick. There is unceasing diarrhea in Ebola which means that a person becomes dehydrated resulting in a significantly low blood volume - http://en.wikipedia.org/wiki/Dehydration. So his blood volume would not be 5000. After reading a few online article about diarrhea, I am assuming it would be significantly decreased.
Also, blood volume is combination of red cells and plasma - http://en.wikipedia.org/wiki/Blood_volume
- Plasma volume is about 55% of the total blood volume (which would be decreased in someone dehydrated) - http://en.wikipedia.org/wiki/Blood_plasma
Viral load is measured in the Plasma not in the total blood volume - http://en.wikipedia.org/wiki/Viral_load.
Considering all this, your equation needs to be modified (I say this respectfully).
The most important fact is the viral load as per Dr. Geiger. According to him,“We did not know if it was possible to retract viruses from the blood,” says Geiger. “But we knew from earlier data that viral load is directly correlated to the outcome of the patient. We thought if we could reduce the viral load through some kind of intervention, then it would be positive for the patient.” It did go down from 400,000 to 1000 per cc of plasma and did not go up after that. More importantly he was in multiorgan failure and unconscious before the use of the HP and improved rapidly after its use. See post 8522.
I completely agree that by reducing the viral load, the overwhelming burden on the immune system is decreased (http://en.wikipedia.org/wiki/Viral_load).
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