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Works if 25% (3.75 million people) buy $600 worth / yr. , which would be 100g per year on average = $2.25 billion /yr revs.
It's hard to estimate usage except maybe assume a classic bell curve, middle 100g being enough, say, for weekends / special occasions?
re: "But I reject that any medical patient needs to sitting around smoking King Kong spliffs of diesel, while in between doing dabs of shatter and then going from room to room in their house with a super charged vape pen."
I don't know, sometimes people need something fairly strong to get to a mental place where thay aren't being consumed by whatever it is that ails them, whether that be pain, stress, depression, emotional upset.
Many years ago, I had some emotional upheavals in my life and by the end of the week I started to feel physically bad as well, so decided to see a doctor. He became concerned because, evidently, my blood pressure had shot way up, so he prescribed valium. That weekend, it got me pretty "spaced out", but it did the trick. Managed to cope after that. Got a grip. Blood pressure anomaly defused. I imagine THC as similarly effective to allow someone to get back to a "happy place" mentally, take a break from their problems which afterward might not seem so insurmountable.
Before we get too indignant, picture the same sort of person, without a prescription, as opposed to shuffling along with his vape pen, staggering and flailing about while guzzling from a bottle of vodka. I think we need to consider relative harm here.
Apart from the risk of sudden overdose death or eventual death due to toxic destruction of internal organs with chronic alcohol over-consumption, unlike THC, and generally worse physical behavior with alcohol, the person paid taxes on the vodka. So I think that your main complaint could be characterized as being that the pot-head is getting a free ride. A little more patience will see that remedied when Rec is implemented.
It's looking more like 7.50 is the line that will try to be held.
Good question. Could be as ipulator has suggested - traders setting up short term swings
Yeah, hopefully it's just trading / MM rebalancing. We're looking at some pretty large blocks getting dumped - usually tweaking for options isn't that macro...
I thought of the good work you did in your recent post when I found that SA article ... parallel -- I agree though that we need to keep tempering our optimism with caution. Still a long road ahead, need more confirmation of expected conclusions.
Some players and conspicuous pundits are going to be very reluctant to change their minds or ever admit they were wrong. Nevertheless, what remains a concern somewhat, in my mind at least, is that, some vested interests in the status-qou, could, what shall we say, still be up to something.
I think some investors are still waiting on the sidelines until they see that Supreme has the actual license in hand. Should get another nice boost when that is announced.
Check these comments from the article I just cited
rkd1961
Comments (73)
Would you give your opinion on the MOA of RVT-101 and it's viability and their P2b success versus 2-73? What kind of chance do you give AXON in P3?
9 Dec, 03:45 PMReply
Lane Simonian , contributor
Author’s reply » The purported mechanism of RVT-101 is as a serotonin receptor (5-HT)6 antagonist that would thereby increasing acetylcholine release. But all these g protein-coupled receptors are damaged in Alzheimer's disease (acetylcholine, serotonin, melatonin, oxytocin, dopamine), so agonists or antagonists of these receptors should not make a difference (unless they are reversing the oxidation of these receptors).
Perhaps there is another mechanism, but as far as I know no other one has been proposed at this time. Based solely on the mechanism proposed, the chances of success are not very good. 9 Dec, 07:39 PMReply
Anavex 2-73: Making The Science Clearer
http://seekingalpha.com/article/3740346-anavex-2minus-73-making-the-science-clearer
If anything, would expect signs of possible manipulation like the tape painting at today's close to continue, right up to options expiration. Someone mentioned 7.50 calls, but it kind of looks like some entity is trying to prevent a close above 7.00 as well.
Perhaps more like a kangaroo going up a hill. :)
Ok, it looks like it might be a Scottrade glitch thing. It usually shows a bid/ask that more or less tracks the CGC ticker on the Canadian exchange. Scott is usually pretty good, but once in a great while will get a glitch. Last year I woke up and had an account balance of $56,200,000.00 due to quote glitch that had a 0.50 pps stock I owned as $5000.00 /pps . Wouldn't let me sell any though. :) Was back to normal about an hour later.
Hopefully will be working properly again soon.
TWMJF - That's weird. I just noticed that the American version of canopy is showing 0 (zero) bid/ask . A trade just went through a few minutes ago... 40k vol on the day...
Wonder what's up with that?
Why is the bid 0.00 but the ask is 0.04? It is trading on the Australian exchange around AUD$0.26, so it's still trading.
Sales are going through on the OTC here from 0.01 to .025 but my 0.02 bid seems to be getting ignored. MM asleep or what?
If everybody owned stock, it would spoil a lot of movie plots. The favorite being the little guy vs. the big nasty corporation. But actually, it's very egalitarian. Anybody can own stock and if enough stockholders want to change something about how a company does business, they can do it.
I notice that the author remarked about having dual citizenship. I wonder, does that mean:
Would you have pay taxes to both countries?
Could you collect Social Security from both?
If you ordered from Tweed, could only order half as much ? :-\
:)
That bad eh, I already had it pegged for the "maybe not such a great idea" list, alongside putting flouride in drinking water.
Well. people have been at it for decades, they don't give up, keep trying everything under the sun. Yet nothing seems to have worked, so far, up until now. The Anavex compounds would seem to be the needle in the haystack. At least, based on my own DD, that's what I think.
The last one on your list, lithium, is interesting. It's not even a compound. It's a metallic element, one of the simplest, #3 on the periodic table after hydrogen and helium. Nevertheless, it has been used medically in the past due to it's psychotropic effects, though it is more well known as a lubricant additive, and, of late, in batteries.
You know how Coca-Cola used to contain a cocaine extract years ago? Well, you may have also heard of a competitor beverage, 7-UP. It used to contain lthium. The name comes from the common stable isotope of lithium at atomic weight 7. The "Up" would of course pertain to the desired effect on mental state or mood.
It seems unlikely to be a cure, you'd think someone would have noticed back then.
Around the turn of the last century, "patent medicine" was big. They contained most anything but the active ingrediant was usually some sort of narcotic, usually an opiate. They didn't actually cure anything, so far as is known, but people were evidently content to take something that would relieve their symptoms such as pain or lethargy. Addiction could also have been a factor in it's popularity. William Durant, gained renown as a top salesman, for example, selling patent medicine, prior to founding General Motors Corp. ( He also sold fire insurance, though it is unclear whether there is any connection to the old expression about shouting "Fire!" in a crowded theater.)
Now we have medicines with real patents as well as lots of money involved. Here again, people have been resigned to accepting anything that at least seems to alleviate some of the symptoms, even if just temporarily. It's about time that enough stones have been turned over that finally someone has uncovered a compound that is actually effective against the cause.
There could also be a large market in the general population, depending, for people needing protection against prions they may have ingested by eating beef from mad-cow-disease cows.
After the prion theory / mad cow story was all over the news a few years ago, the solution was publicized as cattle being slaughtered before they got old enough to develop the disease. The extreme symptoms only showing up in cows past a certain age.
Hmm.
Here's another kind-of interesting thing I stumbled across, which may be relevent to the possible strategies of a certain company under discussion's relation to AVXL market activity. One could wonder if it could explain the jumping on KBIO due to "being interested" in their drug which had been only thought to have a limited (orphan) market...
Johns Hopkins accuses drugmakers of 'gaming' orphan drug law
http://www.fiercepharma.com/story/johns-hopkins-accuses-drugmakers-gaming-orphan-drug-law/2015-12-03?utm_medium=nl&utm_source=internal
Some of us have been holding ( in my case, a bit underwater) for what seems like forever. I added a bit too first thing fri morning @ us $0.21 at the ask , which I guess is 0.27 Canadian.
What's a penny or even a few, at this point?
People who haven't been following this as closely, probably don't realize that inspection is going to be a slam-dunk. Supreme has had time to go over the place with a magnifying glass and a tooth brush -whatever it takes to get everything perfect as possible. I would expect that people who have been waiting for the actual license to be issued will start buying in, which should give us a nice up draft.
It's pretty obvious to many of us that AVXL has been under attack, but, still, seems a bit much...
Perhaps they have been more persuasive, somehow?
I sense it is imperative to stay on the "good side" of the FDA. I was reading about a couple of MS contenders. The gist I got is that the one with bad side effects seems to have gotten the upper hand because the CEO of the other got too outspoken or feisty with remarks regarding the FDA and somehow p!ssed them off. They then were then in the process of replacing their CEO in an attempt to regain good graces.
We know how things often get done in third world countries, and would like to keep believing that our agencies are completely impartial. I suppose it would be interesting to see what impartial criteria was in play to effect favoring such a rapid jump ahead in the approval process of the company you mentioned.
Maybe because the CEO is such a good humanitarian? Yeah, that must be it, no?
I see. Thanks. I thought this was worth a second look.
Hurray! Man, that was a long wait!
Well done. Thank you for your excellent work.
I am a little confused, too. The patient with good results so far was with installing the neural scaffold after draining out the necrotic tissue. I've read results from another co. who tried injecting stem cell and the results were not good, leading one to think Jason might be better of without the additional stem cells.
The gel /stem/injection treatment - seems new and unproven. Maybe I haven't read through enough co. literature yet, but this was not what I expected in the PR.
Considering the abysmal results from the other co.'s attempt to simply inject 10 million stem cells, it seems clear that the new neurons need some kind of guide to help them connect to the right place. How do they "know" where to re-connect? In the other trial I mentioned, with the competitor, it sounded like the patients were still paralyzed but then had pain. What if the new motor neurons were cross connecting with pain neurons? With repairing a broken multi-conductor electrical cable, it is important to splice the right conductors back together because cross-connecting the wrong wires or a short circuit can make the original problem worse.
Wow. That article is pretty vicious. He reiterates the insinuation in another smear piece that Dr. Fisher is engaged in fraud, without actually saying so directly, so you can't make a case of slander that would hold up in court. Paints all animal and by extension, in-vitro studies with a broad brush as meaningless as if he, knows better than accredited researchers in the field, and then, when the company issues a positive PR's to try to counter the smear articles, he in effect, accuses them of pumping.
Since the shares are not yet released from the creditor, where are all the millions of shares being dumped / churned to drive the pps down coming from? Maybe certain hedge fund(s)?
Hit pieces can be composed to provide cover for price manipulation and the price manipulation can be spun as response to the negative articles, so there is a synergy that needs to be maintained for the operation to progress though the hacks are really scraping the bottom of the barrel to come up with anything to put a negative spin on on this one.
Even though Cramer could be characterized as a hack, many people, after watching him on TV, just take these kinds of guys at their word rather than do their own DD . Funny thing is, I once went back and read through all the Cramer stock trading "advice" out there and found that pretty much every point he made at one time is contradicted by another point he makes at another time. He is no Warren Buffet with special wisdom. Instead, he can be expected to depend on a singular skill of orchestrating machinations like was used on AAPL.
Yeah, who dumps a million shares at once like the one around 2:30?
Nobody around here...
A lot of the weird trading is likely the same shares being passed back and forth to accomplish the current walk-down.
I'm thinking of the drunk test the cop gives Steve Martin in "The Man With Two Brains" :)
Also heard that self driving cars could become a reality in 10 years, according to Tesla, so, that could eventually mitigate the overall problem of people driving while impaired whether by fatigue or some form of intoxication. Obviously, would also be a boon to many people with physical disabilities as well.
From the The Devil's Financial Dictionary - Jason Zwieg
REGULATOR, n. A bureaucrat who attempts to stop rampaging elephants by brandishing feather-dusters at them. Also, a future employee of (or provider of services to) a bank, hedge fund, brokerage, or investment-management firm. (See REVOLVING DOOR.)
Regulation fails to stop giant financial firms from periodically destroying billions of dollars of their clients’ wealth and from imperiling the global economy, but it does ensnare smaller firms in tangles of red tape that handicap their ability to compete against the larger firms. That is what lobbyists for giant financial firms call “leveling the playing field.”
:)
Guess we'll be seeing more low volume scatter-shot sideways trading today. Typical for a pre-holiday day.
" Bid long and prosper" :)
That's weird.
So far, just getting "Login temporarily unavailable
Dang. I think Scottrade is down. Anyone else having a problem?
re: Oils oils oils oils oils oils oils oils oils!!!!!!
Oils well that ends well. :)
I'll second that!
Smell of what?
Maybe you stepped in something. Depending what it is, some people consider that a sign of good luck. :)
I'm just happy enough that they seem to be backing off.
Looking at AVXL chart (from fri) extending into after hours. Could that be a mini cup and handle forming?
In looking at other biotech I notice that the more marginal the indicated efficacy results are in previous trials, the larger the phase 3 trials are. Since Anavex has good indications, I expect that a modest to medium size sample group would be sufficient. An educated guess would be under 1000, surely.