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Ed,,,
Please give me a call at 617 584 2403
T. Weikel
tkn (and others.....
Back in the day I was a market maker...That was before high speed BB;and S..even then (before computer matchups of bid and ask)...Even then MMs had little effect on the pps,, and manipulating the share price was very risky. The PPS (like the backup this afternoon is the work of shorts. Some of them are retail and some institutions.
Its sickening when we are up in the morning and these assholes move in, in the afternoon...But Biden is making it very easy for these guys...
I am an MIT grad..SB (Chem E.) and a grad of Harvard Med...1967.
Bionanao has fabulous technology IMO not matched by any other and is up grading in the near future...It is my biggest position....and I have no plans of selling any of my shares...Musk has said this is the future and I agree...The company has earnings and substantial cash in the hundreds of millions...Be thankfull these guys are providing you with cheap shares...
":>) JL
.
tke...
I sold most of my EXRO two weeks ago. My biggest position is in BNGO...
They are to medical technology what Amarin might be to pharmaceutical drugs...
":>)JL
Are you Reddy....
I am a long term poster on this board..I had a fair sized stake in the company (90,000 shares)...Which I ended up selling after the patent fiasco..
At this point I have decided to take another look..This is after reading about Dr. Reddy whining about somebody taking away his toys..It sucks when after a long term of being the pisser that you get pissed on...
A long time before today...Amarin was actively scanning landscape for sources of EPA..and it was their hole card...Amarin had tied up EPA (med grade) long ago..That is why I was so surprised the generics went after the drug..I don't see how the generics have a case when they knew the facts before they started to steal the drug...
I also like the fact we are getting an activist investor..Thero and Kennedy were a couple of rogues...Sounds like the new guys are going to clean up the mess. Whether they want to sell or keep the company is an open issue..But if these guys understand that Vascepa might just be the most valuable drug of them all...Maybe they will choose to keep the company..
Anyway nice to see a lot of the old guys is still around. Hope everyone is doing well..And I am going to say...Amarin is cat with nine lives..and they haven't managed to kill her...good luck to all you longs..
":>) JL
Deep6....
No doubt the chart looks nasty...But it is what is behind the chart that is of importance...Low prices offer "asymmetric bets" ..and asymmetric bets offer great rewards...Take the long tale of Amarin..Before the American Heart Association meeting in Nov. 2018. The PPs in the spring the stock PPS dropped to 80 cents. There was not a ton of optimism to say the least..
Because of my strong background in medicine and physiology. I knew the PPs was insane. I bought 100,000 shares for less than $90,000...After the meeting the price went up and was over $20 for several momths allowing me to cash in for over $1.5 Million...I did hold a portion of the stock and lost a substantial amount later on when Amarin lost the patent trial..
I do not see anything that that contradicts the notion the PPS of BNGO is ridiculous and I have some familiarity with the concepts the utility...I am a graduate of MIT and Harvard Med School...I am also a very long term investor in the stock market having made my first purchase *50 shares of Motorola in the 1950s when I was a teenager..
Best of luck...:">) JL
AEMD....and longevity....
The most important technology is not 5G, not EVs or terra farming Mars..
The next most important frontier is going to be extending lifespan. At present there is no hard evidence that death is guaranteed by age a hundred , or even 130 years. The truth is there is ample proof that none of the aging factors has a definable cut off number...
At present scientists have identified factors that hasten our way to "Dusty Death...Its just that although the knowledge would seem paramount..It is known only to a relative few scientist in the field...One issue is that "old cells" actually can and do secrete chemicals into the bloodstream. There are other factors such as alteration in the DNA (transpondors)
Legend...
Quote... "I believe you are the one that called SQNS your little Microsoft. How has that worked out for you? Another bear raid?"
Never called SQNS my little anything. I Lost some money on INSG...and had a tiny position in SQNS. never had any shares in Microsoft (wish I had some.
:>) JL
1266
Good man Legend. We need to sink these Mariner shorts...
Sue is doing a great job. EXRO has two manufacturing locations now and a number of interested parties...This is going to be crucial to the EVs and
other alternate modes of non fossil fuel transportation...
EXRO hold the keys to more efficient electric usage and longer range batteries. The very heart and soul of electric motors and the determiners of how fast we get these things into the mainstream..
We need to run these shorts through the shredder.
":>) JL
This is the perfect situation...if you buy the PPS will go up,,,
5 K (about S10,000) sent the PPS up three cants...Dump some of your dog food stocks and buy Exro....You will not be disappointed.
":>) JL
Cmon guys,,,
How can you call yourself "Legend" when you only bet "Monopoly Money" people get tired of of doing the heavy lifting when most of you board members are just "Faking it"..
Right now you have a chance to end this attack on Exro and to help yourselve at the same time...
For Heavens sake the PPs is less than $2.50...its only $2.50
":>) JL
Dear Ihub posters...
I am taking this time to alert you to a special situation in EXRO at this time. The stock price has been pummeled by a viscous Bear raid...As I write this the PPS is $2.15...Please understand that this should be construed as an opportunity and not a calamity...
Here's why..
This issue presents a tremendous betting opportunity...as this is an asymmetrical bet. and Asymmetrical bets are the best ways of getting to be rich in the stock market..Here's why''
The individuals who have sold this stock down to this level have created a situation where they have a upside of only $2.15/ share and are at unlimited risk..If you take the other side of the bet..(you buy the stock) your risk is only $2,15/share and your profits are unlimited...
The last time I saw this was in AMRN when the PPS went to 80 cents...I bought 80,000 shares and the price went up over $20...I made over $1,5 mil on that trade..my risk was less than $75K...
This is the same kind of situation..Please understand these situations do not come along very often..
":>) JL
newbie...
Your question..Quote,," how does the purifier distinguish between a particle carrying a "message" spreading a disease vs all the other particles carrying on normal functions that contribute to cellular health?"
Ans; It doesn't...The problem is bad things (cancer and Viruses or their genetic information attacks cell functions or uses them to multiply. The heme purifier does not go after the cancers, viruses or their DNA..It goes after the cloaking system which prevents the immune and inflammatory systems from going after these dangerous invaders. If if the purifier uncovers a beneficial passenger...there will be no attack on the non invader as long as it is not foreign matter...
":>) JL
Saigai...
You miss taking your meds today? Where did you come up with the idea EXRO is just an EV play...Sorry that reality is such problem for you. If you think greed is a disease. Then why are you posting on an equities forum..
Why don't you dump your millions and open up a clinic in central India..
Exro is not going to save the world but it does have the virtue of cutting down the polluting effects of both ICEs and EVs...FYI cattle ranches raise carbon in the atmosphere but no more than gnus do in central Africa or Caribou in the Artic. Exro will cut carbon gases and that is a help...
As far as greed...Why are you involved with stocks? You must be the only guy I ever heard of who bet the stock market to lose money..Don't spend a lot of time worrying about filling the Marianna Trench..Interestingly you could pack all humans currently alive now in a cube whose sides were 1 mile..The trench is almost 1600 miles long, is over 40 miles wide and 0ver seven miles deep at its deepest point...You could drop Mount Everest into the trench and its apex would be a mile and a half under water...
":>) JL
Exro nd the EV revolution...
Basically the move from fossil fuels to EVs is in the "newborn" stage...
Doing DD on the EV revolution I recommend getting and reading the special Jul-Aug edition of Car and Driver all about EVs., This edition costs $6 USA and provides a very good overview of many of the pros, cons and issues about owning an EV...Such as are EVs actually evironmentally friendly...How much range do you need, do EV 's batteries degrade over time...and many other questions..
The answers are complex and depend on situations such as climate where you live temperature changes. Batteries have optimal outputs which are.temperature dependent...Some of the differences benefits versus disadvantages both in motors and batteries are fairly close..Is an EV cheaper to own than a gas car? .Will EVs ever be as affordable as todays cheapest gas cars?
The issue does not mention EXRO..But it is very clear EXRO's coil drive and battery preserving technology could definitely swing the balance toward EVs ..EVs need every bit of improved efficiency of the motors and every possibility of improving the capacity and longevity in the Batteries..Batteries are the heart of EVs and anything that can reduce the demand for them or improve their output or longevity is a game changer..
I don't believe I am blowing smoke up anyones tailpipe when I say EXO"s technology going to be key for Elon Musk or anyone else who makes and sells EV's.
":>) JL
Gbert....
"Why couldn’t the PPS increase correlate with the recent spike in COVID cases?"
Good question...
The "New cases" are "the variant"...Which is much more contagious but much less potent. Think...Like what we use to call a "cold"...
In the field of virology there is a well known phenonium called "pass through"...That is new case are being transmitted by patients with the virus so the recipients are getting second generation viruses and these Have passed through one host...The rule is the viruses lose their virulence with each "pass through". This is true of virtually all viruses. including Ebola...It is probably a survival factor for the viruses and prevents them from killing all the hosts...which would be the end for the viruses..
Please keep in mind most of the discussion of the so called endemic/pandemic...is from the media. who want to scare the shit out of the population so they will stay glued to the Tube and get higher ratings and more ad dollars...same for our crooked politicians who want to fool you into thinking you can not live without following their sage advice. and you better damn well re elect them because Trump caused the plague...and if he comes back you are all going to die...
":>) JL
Hi...
Did I mention the fact I thought this was going to be a very big deal, And I know I posted that I really liked this stock...and was taking a big position. Well this is doing better than I thought...
It seems unlikely that a two person trial...would be enough evidence to draw any kind of conclusion. But in rare situations two patients can be enough and sometime one patient is plenty. And this is the situation with the two terminal patients one who was treated with the hemo purifier and one who didn't get the purifier...The won who was treated went home. Walked right out of the hospital. The other died...The important thing here is the clinicians considered both of these patients terminal (beyond the hope that any current therapy could cure them.) and trust me...I am a former combat surgeon in Vietnam. and have worked in a burn unit and a surgical intensive care unit.. and I can tell you doctors who work there can tell with a great deal of certainty who is going to make it; and who wont.
My guess (since we don't have any explanation) why the price went up is that one of AEMD's other small trials is validating the earlier experience...
GLA ":>) JL
Market getting killed...AEMD up 20%...
Wonder what is going on on AEMD's FDA mini trials..
Hope you guys are holding this...
":>) JL
oxnous...
Jeff Brown is a stock guy with a pretty good record..(not perfect), but pretty good...
He's looking at the current status of the market and he sees 1998- 2001 repeating itself...We have too many "dot coms"; and too few Amazons. The market is gorged on Squares, Door dashes, Zooms and yes.. Netflixes The price/sales ratios of these stocks are crazy high and reminiscent of the pet.com stocks before the dot com crash. Brown says that biotechs are sector you should be in. And I agree..
I particularly like BNGO as it has the best genomic technology and are seriously under priced against their older relatives like IlMN who is trading a hundred times the price of BNGO (Bingo) and has inferior technology. Bingo's Saphyr is miles ahead of IllMN in utiliy and can run circles around it. BNGO should soon become SOC (standard of care)
Ilumna by the way is under scrutiny in Europe for anti trust concerns.
No I don't know anything you don't know...
":>) JL
Why EXRO is going way up...
I do not need to explain to any of you that electric vehicles (EVs) are white hot in the stock market. There is a whole industry dedicated to estimates on how many consumers are planning to make their next car an electric car. This looks like a cinch. But there are a few potholes along the road to the EV future. And one of these is a huge sink hole..And that is batteries. Without a battery an EV goes no where. Batteries require not only lithium..but even more batteries require nickel almost four times more nickel than lithium. Excessive EV utilization is also going to require huge amounts of copper which is used in the EVs and the charging stations.
This of course is going to increase the price of these commodities. But the reality is there is not an infinite supply of these vital components. This is where EXRO comes in. By increasing the efficiency of the EV motors and the batteries is the equivalent of increasing the supply of key elements needed to run the motors. Elements which are in short supply and will cap the number of EVs. This will soon become clear to guys like Elon Musk and my prediction is Musk will sign a contract with EXRO...He doesn't really have a choice and neither do the other EV makers..
Message ..If you want to get rich. really rich...Hold onto your EXRO stock....
Did you hear that Elon?...
":>) JL
new2theparty...
I am a good example of how important the inflammatory system is in determining the course of the disease...I am a poster child for a guy who should have been finished by the virus..I have recently reached 80 years had a heart attack four years ago and had a highly lethal "saddleback) pulmonary embolus three years ago...Well in Feb of this year I tested positive for COV-19...
But rather than a serious course...I had only a temp of 101F for one day. No further fever. and had a runny nose, which cleared up with a nasal spray. I was a little tired for a couple of days...but was perfectly OK by day four...
Why was my course so benign when I qualified for the very worst outcome..
The answer was I was on Vascepa..Vascepa is an omega-3 EPA which has the effect on modulating and moderating systemic inflammation..I was on 4 gms/day and it kicked the crap out of the puny viruses. Without the inflammatory system to aid them, the viruses were harmless...
":>) JL
new2theparty...
Your questions...1) How does the the purifier distinguish between the bad guys (viruses and malignancies)...from the good guys??
Ans: it doesn't. The exosome cargo is mainly information in the form of proteins and nucleic acids. Once the cloaking material, exosomes and sugars, are removed then the foreign proteins and nuclear sequence are destroyed by the immune and inflammatory systems. Because the material is identified as "non self". Proteins which are "self" do not trigger an immune or inflammatory response..
Please understand (most people including the clinicians don't) The presence of the virus is not the whole story and indeed is probably not even the most important. It is the response of the bodies immune and inflammatory systems to the viruses. As the contagion spreads more viruses spread throughout the body and the inflammatory system goes into overdrive and patients die from something called a "cytokine storm" which is really the inflammatory system gets out of control. That is why it is important to destroy the viruses before they get into the "log phase" or before they get into distant cells...
Hope this helps...
Nice day in a nasty market ..AEMD strong..
":>) JL
Re AEMD...
I really like this stock. One thing biotech players understand is the terrible effect of time. And how it takes its toll as the FDA rolls on and seems to throw one barrier after another until as Shakespeare notes "till the last syllable of recorded time"...AEMD may catch a break (and so will we) because the purifier is not a drug (Its a "device")..and in the FDA, devices run faster than drugs...Plus there is a Lazarus effect. the ability of a drug to bring back patients that physicians consider terminal. Takes shorter time frames and fewer patients..
A drug which is confirmed to cure Rabies or Glioblastoma could be green lighted through the FDA "marketing process" While a cure for Acne could take years and many thousand patients..The fact the hemo purifier has already shown it could effectively salvage one COV-19 patient who was deemed terminal...A patient who later walked out of the hospital..Is a big deal. The purifier is being tried on a limited number of very sick Covid patients. We should see the results in the up coming months (or maybe weeks) and that could light a huge fire under this stock...
":>) JL
jasbg
Bingo shares. 42,000...Taking it up the pipe today...Bingo's Optical system is getting rave reviews from everyone in the field and they have plenty of cash...We need a TPST type short squeeze to get these vultures off the PPS..
":>) JL
AEMD is the future...
I have 30 positions in the market and most of them are in the biotech sector...Not all..but most..
Of all these positions I consider AEMD as the one with the greatest potential...How could that possibly be the case?
The answer is that AEMD's addresses the issues of viral contagion and metastases. Viruses are very puny things...So to become unsuccessful parasites..;ie contagion, plagues, pandemics etc that kill its hosts. They must not only be able spread by contact or in the air..They must also be able to spread internally through the hosts and to do this they must be able to use the circulation. Viruses in their naked state can not effectively travel in the circulatory system..as they are identified by the immune system as "non self" and they are tagged and and destroyed by the immune and inflammatory systems. So to game the body's protective systems, the viruses must cloak themselves in self "alleles" Two principle ways the viruses circumvent the immune system is first of all use exosomes which are nano sized vesicles in the cytoplasm of the host cells. These exosomes are tiny bubbles which can store or transport biological material which normally would be attacked as (non self) in the blood stream or unwanted chemicals...The second way viruses can cloak themselves is to coat themselves in sugar molecules
The very clever viruses use these "cargo" containers to evade the body's defenses. Malignant cancers also use the tiny containers to deliver their DNA and RNA into host cells..
What AEMD's purifier does is it removes the exosomes (and sugar molecules) from the circulation and this stops the transport of viruses and neoplastic genetic information in the bloodstream...
":>) JL
What is great about AEMD....
I see no flashing red lights for AEMD...Their clinical research is a little bit difficult to understand, but if you do understand it..It is compelling and has the potential to treat very serious conditions which are lethal and at present can not be treated by other methods. we are talking cancer and viral contagions. These are not trivial and there are no current alternatives..
Aethlon's purifier attacks viruses and malignancies by neutralizing them when they are in transit in the blood stream.. Viruses use the vascular system to go systemic (spread to other tissues). Viruses can not spread in their natural state; Naked viruses without protective covering are identified as foreign protein (Non self) and are quickly deactivated by the body's immune and inflammatory systems. To overcome this problem viruses and cancers can employ strategies which cloak the pathogens in a protective cover. Examples of these are viral transport in Exosomes which are Nano sized vesicles found in the host cytoplasm. Exosomes are like cargo holders which can transport viruses and DNA and RNA..Out of the cell..into the bloodstream and into distant host cells while exhibiting a "self" signature to the immune and inflammatory systems..
Viruses can also fool the immune system by coating themselves with sugars....AEMD's purifier has been shown to effectively remove the exosome and sugar cloaking from the viruses and cancer cells..I am unaware of any other company using these space age medical technologies..
Though I can not predict the future I can imagine the FDA green lighting this technology simply because there is nothing that comes near this in therapeutic scope...
Disclosure..I put nothing beyond the stupidity of the FDA,
":>) JL
Quote
"Textbook dilution in this overhyped Hemopurashit."
Couple of real geniuses. I do appreciate your attempts to get the PPS lower as I am in the market for more stock in this issue..
Your comments tell me you have no knowledge in the medical field..I unlike you am a graduate of MIT and Harvard Med with decades of expeience in medical research and clinical medicine. My take on this is the science of the purifier is very compelling and I do not see years of future Phase 2 and phase 3 incarceration in the FDA before they get the go ahead in the clinics...The reason I say this is plausible indications for this therapeutic modality is serious {lethal) viral infections and possibly blocking metastatic carcinoma..
The FDA can be and usually is a great impediment to medical research because the FDA's initial charter was to counter the flood of patent medicines most of which were not only Homeopathic but actual harmful in the early 20th century. The FDA does act off risk vs benefit...In this case the potential benefit is exceptional. The purifier has successfully salvaged patients with COV-19 who were deemed unsalvageable...And that is a very big deal. Clinicians who work in ICUs (Intensive Care Units)
Become very adept at who will survive and who wont...And it is very much more likely you will have a patient who you think is going to survive who doesn't.. Than have a patient you think is terminal ends up surviving..
There is much BS in the biotech world. Latest is the Biogen "cure" for Alzheimer's...I see them all the time. But I do believe that AEMD's device is very real and I agree with Time Magazine.." this is one of the great inventions in medicine."
PS. about dilution AEMD has about 16 mil common shares...The average biotech has more than 160 mil shares.. Why don't you you do a little fact checking before spewing the BS...
AEMD'Hemo purifier device...and why it is a potential game changer...
I like to keep up in medical science..but I admit I was not up the pathophysiology and the impact that AEMD's "Hemo Purifier"could have on clinical medicine...
There is an enormous gap between medical science and clinical medicine.
Clinicians. The doctors you see are largely retro and make no pretense in terms of keeping up with medical science. In fact the Hippocratic Oath inveighs against treatments that are novel...The oath says "Experiment is Perilous". Doctors entering clinical practice are cautioned not to be the first in their territory to try new treatments. Mal Practice forces clinicians to practice "defensive medicine"..Not only does this raise the cost of medicine some 40%...but also retards medical progress but costs lives..The only winners is the Med-Mal industry...
AEMD's device is a method of preventing viruses and cancers of spreading by using the blood stream...Both Viruses and cancer cells operate by using their DNA and RNA to alter the host DNA and RNA to produce the viral or the cancers own genetic code to produce viruses or cancer cells. The process is complicated by the fact that the programing genetic sequences must traverse the cell wall of the infected host cell. then enter the bloodstream, then penetrate the cells the cancer or virus they wish to infect.. This is a perilous journey because the genetic material must obey the laws of physics and this means the transported genetic material must present present polar molecules to polar surfaces and non polar molecules to non polar surfaces..
The viral or cancer cell need help and they get it from nano sized bubbles in the host's cytoplasm called exosomes.. the Viruses pack up their genetic material for the trip outside the cell,,into the blood stream and into the cell they wish to infect..These tiny bubbles are are optimally designed to be transport carriers and without them the virus or the cancer cell can not spread. Because the cancer cells or viruses would be destroyed in the blood stream without the protection of the exosomes..
What AEMD's hemo purifier does is it stops "destroys" the exosomes in the bloodstream.. This leads to the viruses and cancer to be vulnerable to the bodies immune and inflammatory systems..This should work with all viruses and cancers .
THAT IS WHY THIS IS VERY BIG DEAL...
":>) JL
Harbor6460...
Quote "This is such a joke. Look at the bagholding. Sub 3.00 soon. Dilutiin machime. And no real fda data. 6 people. Lol"
Laughing at your own jokes? Don't think you'll make it as a "standup". starvation is a horrible way to go. Hope you are not actually investing real money in the stock market..Hate to see you lose your allowance...
FYI...Time Time Magazine named the Hemopurifier to be one of the "Top 25 Inventions" as well as one of the "Eleven Most Remarkable Advances in Healthcare." I fully agree with Time Magazine.
I am an MD with decades of clinical experience and have been involved in major medical research with intuitions like Mass General a major Harvard
teaching hospital..Was involved in the development of the intra aortic balloon pump..A device that was developed in the late 60s and is still saving lives.
AEMD is involved in treating viruses and cancer by control of exosomes..this is real space age stuff and definitely at the vanguard of medical research..And they have actually used the device on real patients with real diseases..And take my word for it you don't need thousands of patients to prove significance...When you have diseases which are highly lethal..(eg rabies) even a couple of cures is significant..
As far as a dilution machine...Well the company has less than 16 million
float...not even one tenth of the average biotech....
AEMD is definitely a hidden gem....
":>) JL
Dude'''
Nice to hear from you..Amarin's problems are not in the scope of medicine or pathophysiology..Vascepa is arguably one of the greatest drugs ever.
But the company's problem were related to our regulatory drug system and politics. John Thero and the senior management displayed no skill what so ever and made errors and enemies in the government and in the FDA. The only skill Thero and Kennedy displayed was to loot Amarin's chauffer's to feather their own nests. A great example was provided by North who has ties to J&J...J&J had one entire floor which was nothing but Lobbyists..Amarin never heard the word...Maybe the new CEO can work miracles...
Trying the patent case in the Ninth District...Instead of Texas. Was the business equivalent of Napoleon's Russian campaign. I have nothing to contribute to the Amarin board...and currently own 50 shares of AMRN..
":>) JL
edit...Exosomes and the Cov Viruses..( how AEMD fits into the picture)..
The history of medicine is the history of guesses. Some good some not..
A med school professor once said; The questions in medicine do not change..... Only the answers."
For most on medicine's history therapies were determined by what I call the "peanut butter and jelly" method..
That is you line up 100 monkeys with a disease and you give each of them each something different to eat. If all of the monkeys die except the ones who got peanut butter and jelly..Then peanut butter and jelly was the treatment. Why and how PB and J cured the disease was not important. This method led to numerous mistakes and frequent failures, but had to suffice..in a world where "science" was more like guessing..
We are getting better and the one positive of these destructive viral pandemics is they do force the medical field to dig deeper into the disease process. And these Cov Viruses are improving our knowledge by forcing medical science to understand how primitive life forms can use the genetic language to bypass all our Pentagon of inflammatory and immune systems. and end of injuring us or killing us. The only saving grace is they force us to understand our inner workings at least as well as these microbes..
The Cov-viruses are pushing medicine and pathophysiology into a new era...
Unlike primitive man we are not threatened by lions and tigers. Instead We are being attacked by by an enemy so small that we couldn't even see them before the electron microscope. They are are puny, but clever and defeat us by the only way they could beat us..and that is to use our arsenal of defense against ourselves..
The viruses are not killing us. We are killing ourselves..The bugs do not eat us. They defeat us in the only way we can be defeated and that is by tricking our our immune, inflammatory and coagulation systems to turned against ourselves..
I am 80 years old...In Nov last year I tested positive for Cov 19..I looked for signs or symptoms of my disease. but honestly even though I am the very highest cohort for serious disease ..Old age with a history of an MI five years ago..and a pulmonary embolus 4 years ago..I only had one day where my temperature was over 100F...a slight runny nose..and that was it..
Why was I let off so easily?...Well its not the virus. Its your own protective systems inflammatory, immune, and coagulation that go after your heart, lungs and most of the rest of your body's tissues. The only possible explanation IMO was my protective systems particularly inflammation was being moderated..The virus was not able to ramp up my inflammatory system...At the time I was taking 4 gms of Vascepa,,a drug which is pure EPA an (omega three) which is known to moderate systemic inflammation..IMO this largely prevented the virus from turning up my inflammatory system to the point it was attacking the host..IE me,,,
I'm not sure whether or not AEMD has a high "Peanut butter and Jelly" factor or whether they are are on the vanguard of medical science studying exosomes Exosomes are cool things..Kind of the body's form of Amazon..They take orders and ship out cargo... They start out as tiny Nano sized hollow bubble like containers in the cytoplasm that can ship things inside and outside of the cell and convey the cargo into other cells. Via the blood stream and the lymphatic system.
Biological particles include not only the viruses themselves, nucleic acid fragments capable of effecting cellular function, including apoptosis...but these active particles must obey the rules of simple chemistry and physics. polar interfaces inhibit non polar transport and vice versa..So the body uses these nano sized particles (exosomes) to solve transportation in the blood stream and across cell membranes.
It appears that viruses also have accounts in these tiny bubbles..They can use them for transportation to other cells..or ship active genetic material which create for both propagation or control of the hosts systems..
Apparently in cases like the Covid viruses they have learned how to use these exosomes to transport not only the viruses but Nucleic acid sequences that can effect host cells..
Exosomes are going to be a very big thing in medicine this century.. though they are not in general circulation in medicine at present..The stock market is difficult to predict as are biotechs. But AEMD has the potential to be something big..If it can hold its postion as a leader in exosome pathophysiology..
":>) JL
Exosomes and the Cov Viruses..(and how AEMD fits into the picture)..
The history of medicine is the history of guesses..Some good some not..
A med school professor once said the questions in medicine do not change..... Only the answers.
For most on medicine's history therapies were determined by what I call the "peanut butter and jelly" method..
That is you line up 100 monkeys with a disease and you give each of them each something different to eat. If all of the monkeys die except the ones who got peanut butter and jelly why got better...Then peanut butter and jelly was the treatment..How it worked was not important..That resulted in lots of bad medicine..for example boiling oil on amputation stumps..bleeding for heart conditions etc...
Well we are getting better and the one positive of these destructive viral pandemics is they do force the medical field to dig deeper into the disease process. And these Cov# Viruses are improving our knowledge by figuring out how the primitive ?life? forms can use the genetic language to bypass all our Pentagon of inflammatory and immune systems. and end of injuring us or killing us. The only saving grace is they force us to understand our inner workings at yeast as well as these microbes..
The Cov-viruses are pushing medicine and pathophysiology into a new era...What are we learning?
We are not threatened by lions and tigers. We are being attacked by by an enemy so small that we couldn't even see them before the electron microscope. They are are puny, but defeat us by the only way they could beat us..and that is to use our arsenal of defense against ourselves..
They are not killing us. We are killing ourselves..The bugs do not eat us..It's our immune, inflammatory and coagulation systems turned against ourselves..
I am 80 years old...In Nov last year I tested positive for Cov 19..I looked for signs or symptoms of my disease. but honest even though I am the very highest cohort for serious disease ..Old age with a history of an MI five years ago..and a pulmonary embolus 4 years ago..I had one day where my temperature was over 100F...a slight runny nose..and that was it..
Why was I let off so easily?...Well its not the virus..Its your own protective systems inflammatory immune and coagulation that goes after your heart and lungs..And I was taking Vascepa which is a drug which lowers systemic inflammation. In my case my SI was supressed enough that it could not "eat me"...
I'm not sure whether or not AEMD has a high "Peanut butter and Jelly" factor or whether they are are on the vanguard of medical science studying exosomes Exosomes are cool things..Kind of the body's form of Amazon..They take orders and ship out cargo... They start out as tiny Nano sized hollow bubble like containers in the cytoplasm that can ship things inside and outside of the cell and convey the cargo into other cells..
It appears that viruses also have accounts in these tiny bubbles..They can use them for transportation to other cells..or ship active genetic material which create for both propagation or control of the hosts systems..
Exosomes are going to be a very big thing in medicine this century.. though they are not in general circulation at present..The stock market is difficult to predict as are biotechs. But AEMD has the potential to be something big..If it can hold its postion as a leader in exosome pathophysiology..
":>) JL
Quote "AEMD ready for another big run IMO"
Certainly possible...Check out my last June 16th post regarding AEMD and Biogen. BIIG won the hoopla award hands down...but look at which issue AEMD or BIIG..is winning the money race. I think AEMD has employed its exosome cleaner in some other locales (as yet disclosed) and am guessing they are very pleased with the results. That would be consistent with what the PPS is telling us...
":>)JL
Nub...
I don't know how much experience you have in investing in biotechs..They can be extremely volatile and you have a lot of people including funds who don't know the science and medicine and probably should not be investing in this sector..
In the case of AEMD this advice should be doubled..at present I present two stocks..one is BIIB Who has recently got an FDA accelerated semi approval for an Alzheimer's drug...The approval came after an "Adcom" where the panel acknowledged that Biogen's drug did clear up some of the Beta amyloid which is a calling card of AD...This looks great but the trouble is there is no compelling evidence that removing Beta-Amyloid will improve the symptoms of AD...
The second issue is AEMD..In its latest chapter AEMD's plasma purifier was used in two patient with COV-19 both in dire straights and considered terminal (not going to live) and one of these patients actually walked out of the Hospital and went home after the AEWMD treatment..
Now which of these should you believe. The BiiB result resulted from a Peer reviewed study with a lot of patients. The second was from a small company with no intent other than to try to save a life or two in which clinicians were convinced there were no other options. Most would focus on the Biogen trial..IMO that is a huge mistake. I am much more impressed by AEMD's result than Biogen's. I have a long history in clinical medicine and medical research and I know how hard it is to save a patient when the consensus of the clinicians are that the patient is going to die. And further more considering the pathophysiology..in this case I understand how the AEMD treatment worked and am convinced this is no fluke...And that's why I am invested in this stock and have puts on Biogen...
So I do not care if the PPS is going down because I will be buying more stock when the price drops..I feel confident AEMDs treatment is the real McCoy...
Please understand I am not a qualified financial advisor and this is only my opinion and you should do your own Due Diligence..
Best of luck...":>) JL
StockNewbie,,,
When the cops raid the Whore House they take the piano player in with the hookers..
Yesterday only one of my 28 positions was green,, MARA a crypto stock,,the rest were down...So no surprise that AEMD was "bleeding" along with all of the others..I call it "Bi den wait for the market to drop"...
":>) JL
CBD...
I am not a short seller and hold no short position in this stock..I have no idea what your background is..I am a healthcare professional an MD with a interest in the history of medicine..
The history of medicine was framed nicely by an old professor of mine..
"In medicine the questions don't change only the answers."
Medical science has advanced by errors and misconceptions which continue until this very day, Ambrose Pare was a French "Barber Surgeon" in the middle ages..In his time gunshot wounds of the legs were treated by immersing the amputation stump in boiling oil..The rationale was not (as some of my comrade surgeons imagine) to stop the bleeding..Bleeding from the major leg vessels required tying off the vessels then as is still the case. The boiling oil emersion was done because the thinking in those days that gun powder was toxic and cause tetanus and gangrene. The oil imersion was done after the vessels were ligate and the bleeding stopped. Pare was fairly busy one day and performed 21 amputations. Later he was told they had no available boiling oil. Pare went to bed that night with a heavy heart.he was convinced all his patients would be dead in the morning. To his surprise he found his patients were doing better than usual, Usual being temperatures of 105 degrees.. He thought it was a miracle..
In 1934 the Nobel Prize in medicine was awarded to Minot and Murphy for discovering the treatment of Pernicious Anemia (rampant in the early 20thcentury). Minot and Murphy were awarded the prize by identifying Folic Acid as the deficiency in PA...Turns out Folic Acid deficiency was not the cause of PA, Later on William Castle(one of my professors) proved the true cause was Vit B12...Castle never got the Nobel Prize. These stories are rampant in the history of medicine...Yes we see tangles in AD..but what do they mean and how does it work?...
AD is a disease relating to aging..To my way of thinking most every condition seen in aging is related to the degree of systemic inflammation..The higher your basal inflammatory levels are, the faster you age and I do not see AZ as an outlier..Want to slow down AD..cut down on your systemic inflammation.
":>) JL
Cbd...
Quote..." The causes are known...Check Anavex studies and chromatin structures.."
Take it up with Eli Lilly
":>) JL
cj,,,
You getem Cujo..Rip their throats out..
LOL...":>) JL
AEMD...
On Yahoo...some poster criticized the fact that AEMDs "purifier" which was used on two terminal patients in the last stages of COV 19 (one of the two patients recovered and was discharged) was Quote "Not peer reviewed..and was worthless".
This individual thinks he is an expert on all things AEMD and is bearish does not understand what happened..
It is true the fact one of two patients considered terminal. did survive does not suggest this is a Peer reviewed Clinical trial. The design here was not like a Phase 3 clinical trial studying efficacy. This was compassionate use of AEMD's purifier in a situation that FDA agreed both patients were terminal, and there was no other options...
The fact one of these patients survived is in my mind very promising. When I was in med school I got summer job working at Avco Everette Research labs. Which were working in conjunction with Mass General on the Intra Aortic Balloon Pump. That was back in the mid 1960s..The early use of the balloon pump at the Mass General Hosp.at The Brigham, both Harvard Hospitals in Boston and Maimonides in Brooklyn...Were pretty depressing.. We were also working on terminal patients with terrible hearts and none of our original patients survived..
The balloon pump is still an use and has saved thousands of patients. And believe me we never batted 50% in our first two patients...
":>) JL
AEMD.....
My new favorite....
To those of you who do not know me..I am a grad of Harvard Med School with a Chem E degree from MIT...
This is a very cool situation..(Better by far than the phony Biogen drug recently Oked BY the FDA for treatment of AD,,Approved after an AdCom which failed to show the drug had any clinical benefit. and was going to cost $56K per individual annually..
AEMD is probably going to be slow to be adopted by the market as it is complicated, but the clinical effects are mind blowing..
The physiological benefits involve the actions of "exosomes" that only a small fraction of med students or grads are familiar with..The subject deals with Access..Complex life forms like mammals..Have to deal with two separate and non compatible chemical interfaces which are polar (they have positive or negative charges) or non polar interfaces.. Polar and non polar do not mix.. We know this as oil and water...Water is polar and oil is non polar..Viruses like Covid require the protection of lipid cover to exist in the cell cytoplasm..to transport out in the blood stream and they find this cover in microscopic "vesicles" which in lay terms are bubbles found in the cytoplasm of the host cells..These are called exosomes..Inside the exosomes the virus can survive and be transported in the blood stream..The virus is not doing any great harm if it is floating around in the circulation..what does happen is the virus can be conveyed to the cell membrane surface and the exosomes have the correct structure to penetrate the cell membrane and deliver the virus into the cell where it does the damage..
What AEMD's plasma purifier does is to add an agent which destroys the exosomes' membrane which throws the viruses into the blood stream where it can not penetrate the cell membrane and are neutralized (killed) by the immune and inflammatory systems...
This is the real McCoy......The amazing potential here is that exosome disruption should end the career of any of these or future viral outbreaks and pandemics...
":>) JL