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Sofo pricing - on the other hand, pricing equally for GT2 and GT3 would be very politically correct and GILD surely needs this kind of positive PR material, so they might do the gesture.
I don't think there's a practical way of monitoring but perhaps you can identify those who are at a greater risk.
Some Data from LONESTAR-2 study in GT2/3 patients treated with Sofo/Peg/Riba (and also sofosbuvir + ledipasvir) will be presented at AASLD
The fact that this MRK regimen is a viable player in the all oral HCV arena was hinted before (#msg-93015431) and is becoming more clear with the AASLD abs.
I don't think they'll charge double for 24w treatment but probably some premium.
ACAD
I'm glad we can put this to rest
Only question is how will GILD set the price for GT3?
GlobeImmune
Obviously, their T cell immunity stimulator is no longer an attractive approach in the current HCV era.
ARIA
Xarelto vs Eliquis
ARIA
Let me have a word with the Missus and then we'll see :)
Since this is your money, I'd say neither.
Open a saving account for your grandchildren instead
KMDA - AAT in type 1 diabetes (extension study of the phase 1/2 trial)
http://maya.tase.co.il/bursa/report.asp?report_cd=852638-00&CompCd=1267&Type=Pdf
Glad you've escaped the ARIA crash! May the force be always with you, Jim
You are right of course, but I have lost faith in Teva and don't believe someone can save this dying dinosaur.
Maybe, but more likely Levin grew tired of Frost trying to break his balls.
Stribild
No one can cross Frost!
PLX
MRK/Isentress
One more thing I can think of is if they have learned from previous trials that qD may work fine for patients with relatively low viral loads and will enroll only those in the new trial.
i don't understand unless they reformulate but we'd know if they did, no?
Indeed, but I found the weight details not the vol :)
MRK is trying hard to promote Isentress and the marketing message is long term clean safety but it has a lower genetic barrier and it doesn't appear to be a true qD drug.
I had to check on the size issue (sometimes it does matter ) :
GILD's single tablet regimen: elvitegravir 150mg, cobicistat 150mg, emtricitabine 200mg, and TAF 10mg. Total pill 510mg.
GSK single tablet regimen: abacavir 600mg, lamivudine 300mg, and dolutegravir 50mg. Total pill is 950mg.
Perhaps it would be a meaningful difference in size when you want to add a PI and the GILD mixture already contains a booster (needed also for the PI).
On TAF smaller pill size, I meant relatively to tenofovir not to Tivicay, that would allow to co-formulatr with a PI. Now that we are clear on everything, let's see Epzicom's come back :)
The way I see it docs are conservative creatures (and rightfully so) and since the D:A:D trial they don't like abacavir because of the fear from its lipids and c.v effect. Tivicay is indeed the best integrase inhibitor but its current combo is a problem. GILD or ViiV - it'll be a very interesting fight to watch but my money is on GILD.
Current problem for Tivicay is it will only be in one pill with Abacavir and that's hard to sell.
Lots of noise in the media and Jeremy had to play ball with Ofer Eini
http://www.globes.co.il/serveen/globes/docview.asp?did=1000886100&fid=1725
But was the dog treated with Doxorubicin or other chemo?
[OT] Cybersecurity addendum
I failed to mention the more important point (because it is quite obvious to me):
The weak link in the data saving universe is one's own computer because servers of storage service providers are by far more secured and do not make security errors that common people do. So, if I want to hack to someone's e-mail or data, his/her PC (or someone socially connected to them) would be my prime target and not their iHub, Google, or Apple account on the servers.