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There could be some news out tomorrow to counter and validate this move. or asap. OR ASAP.
Are they implying a HALT tomorrow until this is completed.?.
They know their longs are stuck and could understand the continuing issues and this effort,,,IF,,,...
A R/S without a KICKER!!! / SPLASH / HYPE / PUMP of SOMETHING to VALIDATE this move seems improbable. Obviously we ALL have been wrong with this surprise, so far.
"CM""a good entry point"".?...GLTA...
Good video with Dr Strassman speaking science, past and current research. Also insights of experiences with regulatory agencies. Pre clinical DMT toxicity data. UK stroke centers.
Apparently Dr MW is an active BOD member was accompanying the UK trip. I would like to hear more from Dr Bryan in the future as CM answered questions better suited to the current CSO, IMO. DrKSS asked some off topic questions of Dr Strassman who is A / THE top expert in this whole field. Dr Nutt was attending a Florida psyc conference. Maybe news there.?.
In a 'good financial situation' with $3M reported cash funding developments in Ifenprodil and DMT work.
CM ended with a comparison tracking last year PPS with highs of $.50 and low of $.05, 1billion shares traded during the Nasdaq discussion. My thought is that $.50 is the target price for 'up-listing' and 1 for 10.
Last comment from CM, "the best is yet to come"...
Buy. Hold. Sell...GLTA...
Another psyc company that is chasing PTSD/ADHD/depression. Lots of those...
Shroomz and budz did help me manage the psychologic effects of chemo/cancers. Plenty Other companies are pursuing that too.
I am more satisfied with the dmt use for Stroke and the microdose concepts AGN is pursuing with CMIT.
Also...
Ifenprodil is targeting SCLC tumors and Chronic Cough with NO competition.
I'll stay here.
The bet is 'news' before Nasdaq or a PP. Partnerships and/or grants are a strong possibility, IMO.
Thanks for outside DD on D.MW's ventures after he deserted his obligations here with the disgraceful dec 20 presentation and exit. Probably 'seeing some trends' with those new psyc molecules.
Our Science experts, Yost / D.MW have certainly screwt Shareholders, from Bth to Agn, about our paid for IPs for their personal benefits. Thieves, IMHFO...
We can hope for better commitments and respect for shareholders that invest in AGN IP.
...GLTA...
Impressive obfuscation of my opinions.
COVID is Done and BP vaccines were the winner.
There has been sufficient data collected to apply for other Ifenprodil CT targets with the FDA.
The UK handles CTs and DMT specifically way different than the US/Canada.
AGN has $2+ Million cash on hand...
Full time foot shooting/tripping.?. It's a speculative stock. Go to OWL/DMAC/Bellus MB and pump those at their MBs. Invest in those other stocks.
N
So, $2.8M cash on hand to run the paperwork for the Ifenprodil CC and Tumor Trials AND preclinical DMT work with Charles River. Updating patent applications, ect.
Probably have plenty $ left for initial NASDAQ research/filings/prospectus.
Maybe enough for CEO CM to start contacts with partnership or support possibilities. (lawyers)
No need for a Private Placement or a R/S now at this price, IMO. Some folks are buying as the directions AGN will take evolve...JMHFO...
...GLTA...
Will Dr MW make a reappearance?
Wuhan Virologic institute, Gilead, Rem, Bat Soup. Just accidental virus escape. NO Treatments approved for OVER A YEAR DURING A PANDEMIC.?!
No shots no school. Masks protect OTHER PEOPLE not just ourselves. Flu shots work and apparently so does vaccination for many diseases. Mabs work for cancers.
JJ fkt this whole thing up for GEM and common shareholders, but he doesn't care, He's rich. Hope he falls off that yacht and drowns slowly clinging on to a sinking log.
I discussed the benefits for a NRLA merger before NRXP. Then sold >$.35 as greed and corruption took Dr JJ. GEM supported NRX way back and believed like I did. They are the biggest losers with NRX/RLF/NRXP...GLTA...
Looks like AGN has determined Dosage levels and now Treatment duration has been established for basic start points on a Phase 1 Trial.
Next is how long after 'injury' will this Treatment be effective.
Of course soonest will be best but IF this has results on those already 'injured'.?.
Maybe testing starting treatments at 1 - 6 - 12 - 24 hour and 3 - 7 - 30 day and even for long term 'injured'.?.
There seems to be a thoughtful effort at DMT Stroke with the UK researchers.
...GLTA...
https://themarketherald.ca/algernon-pharmaceuticals-establishes-6-hours-as-optimum-treatment-period-for-dmt-in-neuron-study-2021-11-01/?utm_source=accesswire&utm_medium=pressrelease&utm_campaign=power_play
The IV and Inhaled versions of the Aviptadil and/or Zyemini clinical Trial was for COVID. Wont any other 'use' of the drugs by RLF/NRX need to have separate clinical trials.?. I think they can use data from the recent trial to support asking for an IND covering 'new use' in future trials. Current EUA/(NDA?) applications are for COVID use approvals.?...GLTA...
Yep, Man Up or Woman Up!
Buying, Holding and Selling a Stock are everyone's personal decisions and responsibilities. Blame?*... We don't RUN the company.
Most, as speculative investors in small companies, have written several companies and contributed their opinions and insights. We Don't run the company.*
Someone with $10+ Million here or that can deal on those leveLS?
Incentives are future possibilities OR past history. Taxes?...Speculative situation, IMO...GLTA...
* Lawsuits against Goog by ONT shareholders are still in the courts since 2009...LOL???
Time line of application filings posted by AMG.
Algernon Pharmaceuticals Files U.S. FDA Pre-IND Meeting Request for Ifenprodil Small Cell Lung Cancer Study
September 22, 2021 07:30 ET
Algernon Pharmaceuticals Files U.S. FDA Pre-IND Meeting Request for Ifenprodil Chronic Cough Phase 2 Study
October 08, 2021 07:00 ET
Algernon Files Meeting Request with MHRA for Use of DMT in Phase 1/2a Human Stroke Study
October 13, 2021 07:00 ET
FIFO?
I expect anything to do with DMT will also take longer due to the it being illegal.
The June DMT stroke PR was made Before the Ifenprodil Dartmoth research was known or the even more recent 'interim' IPF/CC data 'trends'.
See "FORWARD LOOKING STATEMENT"...
Now some math? I am assuming the CEO would want a R/S of 1/10 as compared to 1/50. "IF" needed. I and most others (you) are holding as the the exit chances were long ago after final COVID PRs.
News about the Ifenprodil 'Indications" AGN is pursuing will precede news about the psyc angle. IMO.
I am invested/hope/predict for positive meeting results and approvals of All the current FDA and MNRA applications. These May gather a outside attention.
Hopefully shareholders will not need to fully finance those Clinical Trials thru grants/partners. Properly handled AGN could avoid a R/S and have a minimal dilution Private Placement. Maybe...
I hope they proofread any PRs and include the experts at AGN.
Quote:
With the refund cash in the bank there should be no immediate need for more cash until some results for the applications are seen.
You>
Dude, the company reported cash on hand at $3.5M CAD. That equates to $2.83M USD. That's less than $3 Mil to run 3 stat sig clinical trials -2 in the USA and 1 in Europe. I'd love to see your math on the cost breakdown of those 3 clinical trials being run simultaneously.
Reading comprehension.?.
Difference of opinions.!.
Different investment styles. I actually buy and sell with an attempt at profits or to cut losses at some point.
Thanks for concerns about other COVID stocks I played, pfe/mrna/nrxp/rlf/rvv (past tense). BTH is a holdover/loser from faims/blo days profits. Shoulda/coulda just went CC but Dr MW included IPF and I mostly bailed at the first PP, until 'COVID came to AGN'. 4/20 ... I make mistakes too. cnab=bk.
Again, I believe there will be a PPS recovery BEFORE a R/S and-or an up-list, "if a R/S is needed at all". Sponsors/Partnership AFTER IND metings? JMHFO. My recent cost avg is < $.08.
RNG and batteries on-deck...GLTA...
yep, COVID is OVER for AGN. "Results were not 'Stellar' and moving to a Phase 3 against Vaccines and ZBP$ would have been dumb.
The data remains but has not been made public. Just claims of 'trends' for "low O2" and for "IL-6 reduction". Speculative situation.
Ifenprodil HAS made it to Human testing and completed a Phase 2 CT.
The INDs are supported by completed studies for the NEW proposed 'Indications'.
Chronic Cough thru the recent Clinical Trials done by AGN.
The Tumor/Cancer treatment research was done at Dartmoth. THEN licensed.
Ifenprodil has already passed a DSMB Safety review for a Phase 2 CT.
With the refund cash in the bank there should be no immediate need for more cash until some results for the applications are seen.
Any application to up-list will take time.
IND approval timeline is hard to figure. AGN is requesting three different pre-IND meetings.
I am betting against your scenario and that there wont be a R/S before a PPS recovery.** Nasdaq 2022...GLTA...
**if a R/S is needed at all!!!
https://www.drugs.com/fda-approval-process.html#:~:text=Priority%20Review%3A%20During%20Priority%20Review%2C%20the%20FDA%20takes,the%20treatment%2C%20diagnosis%2C%20or%20prevention%20of%20serious%20conditions.
Yes, true. Three drug INDs in 'review', Ifenprodil at FDA and DMT/constraint therapy at MHRA.
My bad, but,
My points were that news from at least one IND and possibly all applications may move forward Before any R/S BS.
The tiered Nasdaq requirements posted by Smoki is also positive.
Attracting support from major organizations and/or partners IS possible. Probable.?.
That's why I invest in speculative stocks.
COVID world wide attention and hype is done or dominated by BP$ now. Positive Ifenprodil IL6/O2 effects and other indications have led to further efforts.
Dr North tumor research at Dartmoth and Drs Nutt/Strassman expertise have put credibility into AGN's future. All JMHFOs...
Buy / Hold / Sell / Sour Grape whine opinions are all here...GLTA...
PFE moved only 20% on their vaccine while mrna peaked at 1000%. Most/all small caps ventures into COVID Treatments have failed because they had to fight BP$ media hype and the FDA's BP$ lackey's.
There are the three IND applications now at the FDA. Chronic Cough and SCLC/tumors for Ifenprodil. There is also the Microdose DMT for Stroke. Those INDs progressing successfully are strong possibilities and should help the crushed PPS. IMO...
Thanks Smoki for reminding us of the 'tiered' Cap listings at the NASDAQ...GLTA...
They must know the requirements for a NASDAQ up-listing.
To progress further on the current drug Trials paths it will cost. Just RS to $2 - $4 will Not fill the revenue requirement or valuation. But we've seen some questionable SPAC deals and claimed "IP valuations".
Maybe a couple of the INDs will be/are completed providing bargaining positions for access to partnerships and/or access to sponsors like cancer foundations etc.
Ifenprodil for Cancer tumors/SCLC and Chronic cough Clinical Trials with a back up of Micro-dosed DMT for stroke.?. Certainly a stronger portfolio of possibilities then many already in the Nasdaq with much higher valuations...IMHFO...
...GLTA...
https://bullishbears.com/nasdaq-uplisting-explained/
Seems like a pretty good fit for Ifenprodil...
The most common causes of a chronic cough are:
asthma, especially cough-variant asthma, which causes a cough as the main symptom
acid reflux or gastroesophageal reflux disease (GERD)
chronic bronchitis or other forms of chronic obstructive pulmonary disease (COPD)
infections, such as pneumonia or acute bronchitis
ACE inhibitors, which are medications used to treat high blood pressure
smoking
postnasal drip
"These events do not in any manner affect our efforts to bring a lifesaving drug to patients worldwide."
There was the chance to be part of the COVID solutions last year... BUT... JJ GREAD was too strong and wanted more. A combination with RLF and then ACER ++ could have been producing Aviptadil all thru 2021. The combination could have been self supporting. A possible REAL Pharma. BUT NOOOO. COVID has passed Aviptadil/Zyemini by due to repeating FUBARS from JJ. ONE Man/Doctor(?) to BLAME/Accuse/Prosecute...
Now the NRXP PPS is at a historic low. Pre deal was $70 high and closed >$30. RLF is heading to single digits. JJ must be SO proud. At this rate I hope he has to sell that Yacht. I hope he ends up in JAIL for FRAUD/Conspiracy...
This one Man (Dr?) has 'literally' KILLED patients for this/HIS self righteous GREAD. NOT Figuratively.
GEM is losing $Billions along with shareholders. BRPA?
A Very SAD story. Some fair flipping but as a Future and Present BUSINESS, JJ has Personally KILLED that too. EMA?...JustMyHumbleF*ckingOpine...GLTA somewhere else...
Oil and Gas rights sold to Cammeron/SLB.?. Got to pay the management salaries...
Rant follows...
Maybe this could be a SPAC/re-merger shell.
Jr. should be 'turning brake hubs' with that nice CNC we bought him.
Ran his Dad's company in the ground. Even called long time investors begging for the R/S and sale of the O+G rights.
"Big" Possibilities in Other areas, mining/wastewater, etc...GLTA...
Sorry for all that believed, they got some of my $ too. BRPA should have insisted on a NRLA instead. (Acer/NRX/RLF). That could have been something. JMHFO...
I'm happy to have left earlier as I smelled this Rat too strongly.
Deal was at $30+, high of $70, started with BRPA at $10.
He leven ooks like the slime he has proven to be. May he 'rest in Jail', ass-up...
Gilead's/Wuhan V.I. Remdeathisnear was shown to be a Killer early but BP $ / politics let it completely dominate the Treatment for COVID. BP$$$
"Attorney Renz is also in possession of Remdesivir death data from the Medicare Tracking System that has been withheld by the government from our citizens.
The Remdesivir data reveals of the 7,960 beneficiaries prescribed Remdesivir for Covid-19 2,058 died. That is 25.9%.
46% of people died within 14 days of the Remdesivir Treatment. The Remdesivir Treatment was established in U.S. Hospitals at the direction of Dr. Anthony Fauci.
Serious adverse events were reported in 131 of the 532 patients who received Remdesivir. That is 24.6%.
Attorney Renz says ” This begs the question… Why is this the protocol in American Hospitals? Does this appear “Safe and Effective” to you?”
https://www.newswars.com/bombshell-from-attorney-thomas-renz-nearly-50k-medicare-patients-died-soon-after-getting-covid-shot/
"How about reserving full judgement about data until we actually get to see it?". I use words like if-may-apparently-could-imply in my sentences on purpose.
So You think AGN should wait until we see Auz data to expand the work with Ifenprodil / CC?? Really.
The FDA will review the applications and data that AGN presents. That apparently is 'in process' for a Phase 2 Chronic Cough CT that will be 'Powered' to meet sig stat'.
I never go 'all-in'. I'm an opinionated piss-ant BTH (x-BLO) poster on this obscure MB. Buying small and steadily now. Certainly not doing $10M deals.
I enjoy the banter. This OTC stuff is speculative 'semi-informed' gambling. hacax is doing fine but moving to habdx lately. Been out of BA for years and OI-others for a decade +.
The dilution had sure damaged past BTH holders but where is some thing better for the current PPS.?. Stupid to sell here. IMO. ..GLTA...
As I have said, COVID for AGN is done. Too expensive to go to a Phase 3 Trial with way less pertinence now. Probably why the FDA responses were not shared. There apparently were strong enough "trends" and 'signals' seen so that they will turned into valid FDA applications and CTs for Ifenprodil.
AGN is working toward the continued concepts of NDMA actions on the lungs. Now as both a CC remedy and for tumors due to some IL-6/low O2 data for Proof of Concept/whatever.
I should have referred to one of my previous posts re; REM/Wuhan V.I./Gilead/FDA/CCP. The post was supposed to be sadly funny.
BUT.
Ifenprodil 'may' have been a better treatment than REM, IMHFO. NA. Certainly does 'no damage' and 'may' have helped.
Few are arguing about the bad Safety record of Remdeathisnear.
PFE is working on a PFIzermectin type 'new drug' for COVID treatments.
No one is saying Ifenprodil treatments for Lung affected diseases may be un-Safe.?. "Powered' Phase 2 for Ifenprodil Chronic Cough CT.
Finally, we can expect better management handling of the paths forward. There are obvious improvements already.
There is strong support from AGN's SMEs. It's very encouraging to have our experts do the talking, in PRs ect, about continuous developments in the company's projects...GLTA...
Maybe LS* can do a PP until we get a BP partner's/sponsor's $$$.
Thanks for the past support from the 5...
Dr Falsely and worldwide political favor claimed Rem was beneficial. Gilead's/Wuhan V.I. Remdeathisnear was shown to be a Killer early but BP $ / politics let it completely dominate Treatment for COVID.
They took up so many CT sites and beds last year that small Trials could not be run. Like AGN's difficulties to recruit for their South Korea and International CTs.
Can't compete with that kind of money or political backing.
Ifenprodil certainly was Safer and probably more effective... "Signals" are there and CC could be the perfect target...
Doesn't matter now, BUT WTF. Some would call Rem a criminal conspiracy...GLTA...
https://www.newswars.com/bombshell-from-attorney-thomas-renz-nearly-50k-medicare-patients-died-soon-after-getting-covid-shot/
AGN / Dr Nutt have posted news on their Micro-dose pre-clinical work.
https://www.iflscience.com/brain/dmt-increases-growrh-rat-neurons-40-percent-new-data-shows/
Big Pharma period. Antivirals and MABs... $2000 a dose?
Some 'funny Rem' stuff too...
Fkn Sad.
https://www.msn.com/en-us/health/medical/a-pill-to-treat-covid-19-we-re-talking-about-a-return-to-maybe-normal-life/ar-AAOSro2?ocid=msedgdhp&pc=U531
Staying, Hmmmm... Thanks for an answer and your opinions...
Original BTH shares HAVE been hurt and I am investing in the future. COVID is done. They rightly moved on and did not do an expensive Phase 3 CT, IMO.
I see a smart more experienced group heading into this next phase for AGN.
Cancer may be the easiest to get funding for and the fastest to recruit patients and then see data, IMO...GLTA...
That may/must be next. Been a while since the '18 run. The R+D should be done soon...GLTA...
I'll be specific. Do you suggest selling after this CC info? Your well winded opinions and YOUR claimed intended action was to sell here.
I feel AGN as acquired better personnel, Drs North/Strassman/Nutt. They brought back Dr MW as an important contributor.
There appears to be a more aggressive BOD.
Micro-dosed DMT may have better acceptance than other Psyc plays, IMO.
Cancer/Tumors.
CC.
Wish for AGN to find a 'lung Cancer' sponsor, ASAP.
?Sell? or try to enjoy the ride they are again trying to make.?. JMHFO...GLTA...
I've lost a portion of the '18 BLO run profits on COVID plays thru AGN and others. No risk little reward. Always trying to buy Lower and sell Higher at some point. Wish I put more $ into GMST and MRNA and less in PFE and therapeutics.
So you've finally had enough here and are moving on. This is the IPF/CC news. Be glad to not have you p*ssing in everyone's soup anymore...I wont go back and get posts/promises or trading opinions on the OTC etc...
This speculative investment is trying to move on too, IMO. 'Buckle up Butter-cup' or 'stand up- hook up and shuffle to the door and then jump out of the plane'... Dr MW is back?
...GLTA...
Cant resist another comment.
We wont get 'fooled again'...WHO...
How did those 'police action/nation building thingees like VN-Iraq-Afghanistan work out. DChenny's mouthpiece was a good man and meant well, even though he sleazed out of his VN deployment. IMO.
It took 50M shares to start the IPF/CC Trial.
Money was hard to raise and the BTH technology is still on the shelf gathering dust. Yost took a copy and BLO benefited too. BTH shareholders paid. The same as with the Drug portfolio from NASH
Other PP deals paid for the South Korea COVID attempt and later the 'International' COVID CT.
""A relative reduction of cough count in these patients """is""" being viewed by the Company as encouraging news.""
It seems that their 'open label' Trial HAS produced enough "signal" to now seriously target CC.
The 'International' Trial has produced strong enough data for IL-6 to target Cancer Tumors. Supported now with Dartmoth data.
DMT microdosing for Stroke seems to be a well supported path with Dr Strassman and Dr Nutt.
Maybe with Dr Williams back, there may be some efforts directed toward advancing the NASH IBD or CKD drugs.
It's a speculative investment...
"knowledge is directly proportioned to learning from mistakes, if you make no mistakes you probably aren't doing anything.
I LIKE the new BOD and the efforts Algernon now have in work...GLTA...
1abc. No absolving the walk away and that damage which CM and shareholders deal with still.
Future co-operation about scientific decisions and better planning with the existing DMT stroke path and the Ifenprodil Cancer, CC/ARDS, stroke paths will benefit from an Involved Dr MW. Shareholders really took the beatings from this lack of involvement/decision making.
Dr MW / NASH were well compensated at the initiation of AGN, at the expense of BTH shareholders.
I hope all have learned from the difficulties of the company's efforts.
Dr MW may earn the CEO job through future efforts or/and connections. But, I see him as a 'brain guy' and not a 'sharp pencil' guy.
We will need partnerships to reduce dilution. We need the Skills of All AND some better Luck. I think the whole group realize the NEED to show some success for shareholders...I Hope...
Novotec has been a huge disappointment recruiting the IPF CT. Wish in one hand and reality in the other...GLTA...
A Good day with Real news. Thanks for posting your DD to help us all understand better.
Some strong internal moves for AGN today too.
Only one pill/capsule and it's from Novartis.?. The rest of the knock-offs are infusions.?.
I like to find the sponsor for Dr North's Dartmoth work with Topotecan. That may give us more clues...GLTA...
PS
IMO as a survivor of Cancers there is some weird gratification with an infusion, feels like actions. Ifenprodil has both IV and oral formulations.
Isn't Topotecan a Novartis Drug. I'll take Merck or GSK, no problem. My Past DD>>>?...
"Topotecan has a commercial name of Hycamtin made by Novartis.
https://www.novartis.us/sites/www.novartis.us/files/hycamtin_inj.pdf
Maybe they are interested in Dr North's results. Maybe they already know? AGN licensed the MOA. Partnership Dreaming?
"Significant results with the combination of Ifenprodil with Topotecan.
Dr North research
"Xenografts from mice receiving a daily dose of Ifenprodil (2.5 mg/kg) over 10 days decreased their size by ~30% and maintained them at a size below that at day 0 until treatment ceased at day 10. Afterwards tumors began to recover and grow but at the same rate as control tumors (P<0.001). 2.5 mg/kg is considered a well-tolerated dose and did not impact the health of the animals.
Xenografts from mice receiving alternate day doses of Ifenprodil over 9 days (2.5 mg/kg) or topotecan (days 0, 2 and 4) showed slowed tumor growth compared to vehicle-treated controls so that each agent restricted the rise in tumor size to about 2.5-times by day 16, while controls rose to an average of 9.2-times. Tumor doubling times were 4 days for controls, 9 days for topotecan treatment, and 12 days for Ifenprodil treatment.
Xenografts from mice receiving alternate day doses of Ifenprodil (2.5 mg/kg) plus 3 mg/kg topotecan on days 0, 2 and 4 seemed to arrest all growth over the 16 days of observation, and the tumors of all individual animals behaved in a similar manner with little scatter. From this study, there was clear addition through the topotecan and Ifenprodil combination (P<0.01) with marked synergy for smaller tumors (P=4.7E-4)."
"In the pre-IND meeting request application, the Company is confirming the direction it plans to take in the development of Ifenprodil as an adjunct to Topotecan for the treatment of chemo refractory SCLC."
The worm turns, deserter returns...GLTA...
Maybe some should put the whine and the smack down back in the 'mirror' .
Rants show obfuscation of some personal Failures of decisions, IMHFO. Your money sh*t/your responsibility, let that marinate.
Invest in Bellus, PFE or MRNA.
Maybe Respect OTHER's and their decisions.
Hind sighted tantrums? Sad...
...GLTA...
Those with excessive negative opinions may want to leave to other investments, instead of continually shooting themselves in their two left feet while making collateral damage of other people.
Common respect / courtesy for others at the table?
I expect that strong efforts are being made to move forward on several fronts. Still speculative. Looking for a partner, not a PP...GLTA...