Algernon Pharmaceuticals Inc (AGNPF)

[tcm55]

Isn't Topotecan a Novartis Drug. I'll take Merck or GSK, no problem. My Past DD>>>?...

"Topotecan has a commercial name of Hycamtin made by Novartis.

https://www.novartis.us/sites/www.novartis.us/files/hycamtin_inj.pdf


Maybe they are interested in Dr North's results. Maybe they already know? AGN licensed the MOA. Partnership Dreaming?



"Significant results with the combination of Ifenprodil with Topotecan.

Dr North research
"Xenografts from mice receiving a daily dose of Ifenprodil (2.5 mg/kg) over 10 days decreased their size by ~30% and maintained them at a size below that at day 0 until treatment ceased at day 10. Afterwards tumors began to recover and grow but at the same rate as control tumors (P<0.001). 2.5 mg/kg is considered a well-tolerated dose and did not impact the health of the animals.
Xenografts from mice receiving alternate day doses of Ifenprodil over 9 days (2.5 mg/kg) or topotecan (days 0, 2 and 4) showed slowed tumor growth compared to vehicle-treated controls so that each agent restricted the rise in tumor size to about 2.5-times by day 16, while controls rose to an average of 9.2-times. Tumor doubling times were 4 days for controls, 9 days for topotecan treatment, and 12 days for Ifenprodil treatment.
Xenografts from mice receiving alternate day doses of Ifenprodil (2.5 mg/kg) plus 3 mg/kg topotecan on days 0, 2 and 4 seemed to arrest all growth over the 16 days of observation, and the tumors of all individual animals behaved in a similar manner with little scatter. From this study, there was clear addition through the topotecan and Ifenprodil combination (P<0.01) with marked synergy for smaller tumors (P=4.7E-4)."