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I am middle bullish about nwbo, BUT LC has a point with the 68 patients!
Nwbo keeps this group secret like an ugly daughter. Why no results/details?
Not nice and at least a bit strange.
Right. But if too many predictions fail you lose trust.
external control groups: its not so simple like some (cheerleaders) people are telling you.
in detail; first see the fda protocol:
https://www.fda.gov/media/164960/download
Page 4, (page 7 in pdf document) there is the important sentence:
"Sponsors should finalize a study protocol before initiating the externally controlled trial, including selection of the external control arm and analytic approach, rather than selecting an external control arm after the completion of a single-arm trial."
-> not done by nwbo.
Also see footnote 18: very clear.
Page 13 „Analysis Considerations“ much clearer:
"Before conducting an externally controlled trial, sponsors should develop a statistical analysis plan that prespecifies analyses of interest, such as analyses of primary and secondary endpoints, calculations of statistical power and sample size, and plans to control the chance of erroneous conclusions (e.g., to control the overall type I error probability). The statistical analysis plan should be submitted along with the protocol to the relevant review division before initiation of enrollment in the clinical trial for the experimental treatment.“
So - we think - NWBO has a max. (!) 50-50 chance to get through the application because of the of the subsequent change of the study protocol and the subsequent change of the control arms.
But its not zero !
Hope, my concern is that DCVax will not be approved without a further phase 3 study.
And only in combination with other therapies/agents. It´s a guess - no security.
(Beside: the combination approach is - from my point of view - a real progress and not
debatable like the actual DCVax trial).
Very critical and profound article from good scientists!
All in all: its not enough if we stay in our "nwbo-twitter-self-fulfilling-bubble", we must
also see the legitimate criticism and discuss (!) it.
https://www.sciencedirect.com/science/article/pii/S0035378723009190?via%3Dihub
new article in a renowned journal (germany)
nwbo is mentioned.
link:
https://www.aerzteblatt.de/archiv/229940/Glioblastom-Eine-Impfung-gegen-aggressive-Hirntumoren
To all: private is private! Respect it.
Waiting time soon over!
Tragedy to the greeks, science to Northwest.
Yes things come together now - finally.
The next weeks will be interesting.
(From the source).
Everything on track! But need a bit of time. Journal & UK.
... they had problems with the peer group: some questions arrived from the
reviewers. seems not so easy to solve/answer, all is some weeks ago ... we will see.
indeed a brilliant rap )
" ... have not been lazy in the last two years but actually progressed on all those parameters ... "
> not lazy, but they are a too little company to handle this in a better - or to be precise - in a more professionell way.
And beside all positive you can - for sure - say about nwbo: there is a better way how you can handle the last year. the publication (and this comes for sure) will decide if nwbo grows or dies.
Everything is fine ... wait a bit.
(last days was a lot of "Othello", but in the end
the science and the good will win).
internal source
Right - but 80% of this desaster is because of the poor performance from nwbo
in the last days!
Its time to finally make the management responsible. Dont take any more energy on the shorts, instead push the management of nwbo that they do their job: now! quick! clear!
https://aacrjournals.org/cdnews
-> thats the result when you underperform in an important presentation! sad.
file:///C:/Users/schle/Downloads/ijms-23-05396.pdf
Right, NOT in the keynote section!
Keynote speaker? Where? I just checked the site ... ?
link:
https://events.nyas.org/event/28ca5e39-51a7-4e73-be3d-78089c92d596/websitePage:b2003696-e9f8-4553-9851-45c516a58097
Be cautious! I know the same plans for trips, partys etc. with cel-sci!
smart (!) people were predicting success, success - must be. in the end you know the story. i think nwbo has a stronger science-approach, better scientists and so better chances to success - but be cautious.
... all will be good in this year. 2022 IS the year of Northwest.
internal source
I am one of these warrant holders. And my core position I keep to the end
No Mr. Hoffmann this is important. Dr.S.
FINALLY AFTER 21 YEARS OF WAITING.
Sushi you are a freak but like your style
No TLD before or at ASCO. But all is ok.
(As always only a private opinion)
Troc: the process of analyzing is much bigger than anticipated. millions of data - in real, not meant figuratively. also the point of "publication" is not so easy and quick done, they have a lot of choises in this field now - the interest is big. perhaps there will be 1-2 little in-between-announces.
i join this because here we have a real nice nwbo-family
Parker, from a direct, internal source: nwbo will have tld in 1-3 months if all goes well as planned. also they want to tld with "pomp and circumstance" - off course in a scientific way
Bassin: cool research - on the field! hands on!
Thanks Xena for the NWBO tip 1 year ago!
All the best, Chris.
Senti, you are a loyal and good worker on this board!
PS: tld roundabout end oct until nov. direct source
No RMAT, no BP, etc. / The answer is very simple: "just process takes a long time". thats all. and update in next days. direct source.
stay tuned.
High Xena, thanks a lot that you brought me to NWBO months ago!
Chris.
I am german and can calm you. know the place where nwbo germany is located
and some more infos. this german tax thing is not crucial.
thanks sushi!
Trickle STOP or I inform police!
drs.
Thanks Ike!