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hey xuan, hope you're ok, I can finally get out on the last run after several months of patience. These scammers gerry and dror finnally succeed to suck around 10K from me, congrats to them. Last year Shakerzz pumped this stock, this year stockegg and asscociates pump it. I should recognize gerry and dror are very good scammers, they only publish news with information where it's impossible to verify and able to attack them for jail, they never publish any financial $$$ on the news, and they print shares like toilet papers to make money, very clever unlike ckys ceo. glty
lsd, it's really sad to see the pps at this low level. You know, the main truth is the efficacy of Nicosan, if it is the case I can assure you that the investors will win tons of money. I think all the investors must push the company to know the answer to this fundamental question, did they do a phaseIII trial, if yes when should it be completed and publish the results to prove the efficacy of Nicosan ?
Or there is another unofficial way, get some funds from the investors and pay someone in Nigeria to get the information about the efficacy of the drug. glty
It's unbelievable to see the pps so low, all you say is really legit. In my opinion there is only one and main truth the investors should know and I am sure all of you have raised this question once : is Nicosan effective ?
That's why in US for example there are 3 clinical trials phaseI, phaseII and phaseIII, especially phaseIII to show the efficacy over a large number of patients. I think you all know NAFDAC has approved Nicosan for Nigeria market without a phaseIII clinical trial completed by Xechem, and that's not the protocol even it is in Nigeria. I did have a very long discussion with Howard Becker last year on that issue, he said there was a financial issue to solve first and so on but I don't know wtf they are doing, they should consider the phaseIII trial as a priority at same level as the full factory because all the SCD scientist community are waiting for that, prove officially the efficacy of Nicosan, complete the phaseIII trial and publish the results. There are millions of patients who suffer from SCD, prove it works and it will be sold like cakes, very simple like that. I don't know what is the status of this trial and even they do it, I will be very interested to know that. glta
Gerald Sklar and his clowns really make me laugh, by the way he is getting old, I hope he should retire soon and won't do any more damages, really shame on this guy.
Dew or other scientists experts could you please give your opinion on the following abstract ? Thanks in advance and regards.
The effect of corticorelin acetate on peritumoral brain edema: An interim report of an open-label study as part of a phase III program.
Sub-category: Quality-of-Life Management
Category: Patient Care
Meeting: 2007 ASCO Annual Meeting
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Abstract No: 9095
Citation: Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings Part I. Vol 25, No. 18S (June 20 Supplement), 2007: 9095
Author(s): L. Carr, L. Mechtler, L. Recht, A. Hormigo, N. Paleologos, J. F. Alksne, E. Arenson, J. Raizer, M. G. Shulman, CAPBrainEdema [Corticorelin Acetate Peritumoral Brain Edema] Study Group
Abstract: Background: Steroid treatment of peritumoral brain edema (PBE) in patients with malignant brain tumors (BTs) is frequently associated with debilitating steroid side effects. The investigational agent corticorelin acetate injection, a synthetic peptide identical to h-corticotropin-releasing factor (hCRF), compared favorably to dexamethasone in reducing PBE in animal models of primary or metastatic BT. Toxicology and clinical studies including a pilot study in patients with malignant BTs published in ASCO's Annual Meeting Proceedings, showed hCRF to be safe and virtually devoid of steroid side effects. Methods: Following completion of follow-up periods for one of 2 randomized, double-blind phase III trials comparing corticorelin acetate to placebo or dexamethasone, patients with primary or metastatic BTs, PBE on pre-randomized study MRIs, and Karnofsky Performance Scores =50 were enrolled in an open-label extension study in which they took 1.0 mg corticorelin acetate by subcutaneous injection bid. We tapered dexamethasone maximally as tolerated. Patients were assessed every 4 weeks. Results: Of 47 patients who received open-label corticorelin acetate for up to one year, 28 patients continue to take it. Corticorelin acetate was safe and well tolerated, with no related deaths or SAEs. Patients typically refractory to reducing steroids - including at least 5 patients >55 years of age, 7 patients with recurrent brain tumor, and 11 patients in whom prior attempt(s) to reduce dexamethasone had been unsuccessful - reduced dexamethasone with improvement or resolution of steroid side effects. We will present data in the first 30 patients to take corticorelin acetate for at least 12 weeks [the largest and longest-treated group reported to date] including changes in steroid side effects correlated with net cumulative changes in dexamethasone, and treatment-emergent AEs. Conclusions: This interim analysis supports corticorelin acetate's long-term safety, tolerability, and steroid-sparing potential. The outcome of the ongoing randomized trials may determine whether this innovative agent leads to fundamental changes in the management of PBE in patients with primary or metastatic BTs.
absolutely, it is clearly needed for stroke patients as the current drug tPA has only 3 hours time window, not sufficient. Most of the failures were neuroprotectants, Viprinex is not a neuroprotectant and works by reducing fibrinogen levels.
Dew, there is another drug Viprinex from Neurobiological Technologies currently in phaseIII clinical trials which extends the time window to 6 hours.
hi all, I am still around crazy, no worry, just waiting for some good news here, I am quite busy with my investments in biotech companies who are moving up. glty
wow, really strong volume today, good setup for a momentum. glta
There is much more interests in PMRX than WMTG, only with 1 PR and the stock is moving with good volume, there were a ton of PR's in WMTG and no interest at all, if Gerald Sklar does not understand that he should be very stupid and blind and doesn't know how to make money.
Thanks alot for your explanation, I really appreciate. glty
could someone please explain what n and p value mean in a trial results, for example n = 61 and p < 0.005 ? Thanks
Thanks Fid for your answer. glty
could someone please explain what is the difference between a SPA and a fast track status, which one is better within FDA ? Thanks
lonie, you have a very logical mind, it's good...by the way, from my dd with third parties (not the company) I can't conclude if they have gold or not as nobody has seen the gold, but Dror has taken some actions, if they don't have any gold why has he taken these actions ? in that case, flip and flap some shares, keep the core just in case, and we are all happy :) glty
yeah crazyjogger, I understand and respect your view, we are all shareholders and don't want anybody loosing money, but that is part of the game, Gerald Sklar and associates are the persons to blame. I am longterm by default but I need to correct my way of trading here depending of the situation. I hope they can deliver and we all win. glty
crazy, I think you must flip my friend, buy low and think that they don't have gold when it's going up, Gerald Sklar and partners are just bs imo, don't let them got you. jmo and glty
I was in POTP since last week, very low price. Yep, this stock was beaten to the ground, the last update on their pipeline was punished by the market, but if you read that carefully their phaseIII was not so bad, just a delay on the second phaseIII but nothing wrong with the first phaseIII on which we will have news at the end of the month. Take care, it's speculative. The company does not have tons of cash, if the interim analysis is positive they are on a good position to negetiotate a good deal, if it's negative it's better to stop it, it's a question of financing, it's a good decision imo. glty
The interim analysis was an unscheduled event, so the question is why ? I agree with you, it is just for better future financing deals. The company needs to raise cash to keep going on the operations, by selling stock equities or partnership. If they wait for the 1st phaseIII to be fully completed it may be too late in terms of pps performance. So an interim analysis is appropriate and if positive it will give a boost to the pps and then the company can negotiate a good deal. By the way there was a huge volume yesterday, probably some huge buyers who believe it. jmo and glta
I am back on this stock since last week. The interim analysis was an unscheduled event, so the question is why ? The company needs to raise cash to keep going on the operations, by selling stock equities or partnership. If they wait for the 1st phaseIII to be fully completed it may be too late in terms of performance. So an interim analysis is appropriate and if positive it will give a boost to the pps and then the company can negotiate a good deal. In my opinion the interim analysis will be positive and the company should have some good news about that before taking this decision, although only the independent DBMS knows about the results. glta
biotech POTP is on fire with a huge volume for this stock, speculation will move it hard. glta
biotech POTP huge volume today, news about phaseIII interim results on the cancer NSCLC at the end of the month. glta
The bioctech sector has been hurt recently, I am looking for biotechs at the bottom with low volume. I am accumulating NTII which is at the bottom pps and looks very promising, other picks proposal are welcomed. glta
you're right, I may give a call back to check, it's worth a try, but I mean it's the responsibility to keep the shareholders informed, that is exactly what Gerald Sklar misses. glty
lmao, screw this clown Gerald Sklar and his puppets and wmtg, it is what he deserves by playing with pmrx shareholders.
Until Gerald Sklar keeps promises on what he said about gold in PMRX, for sure I will stay away from WMTG, it's all about credibility. glta
yup, it's a good way to do imo...I am not surprised to see a pop real soon with all the shares accumulated at low level.
js, it's a nice test, we are on a buy zone. glty
Alert NTII, it could have huge gains on this biotech company, bottom price like EPCT or AVNR before the run recently, good volume yesterday. glta
Taki, weeeeeeeeeeeeeeeeee, look at Gerald Sklar and family to put lipstick on that pig WMTG, bwaaaaaaaaaa, really funny...I don't know how this man and his family can get back credibility, maybe he will finally deliver in PMRX, lol.
not early retirement but quick bucks gain yessssss, weeeeeeeeeee.
lol, weeeeeeeeeeeeeee. glty
agree, most pinksheets dilute, it's a dangerous game, but here from this current price you can still win. glty
lol...maybe he forgets that we are on pinksheets, everything is possible, the worse and the better. glty
crazy, the information I got last year from Umicore Thailand is that they don't have the necessary equipments to refine a huge amount of gold as requested by Dror, so they recommend Dror to go to Umicore Germany which is much bigger. Sure it does not mean that PMRX has this huge amount of gold to refine, but there are facts about these actions, does it mean they might have this huge amount of gold? Maybe, will see. glty
we all hope for that Xuan, I put all my shares on hold since a while now, it will worth alot some days or nothing, no between. glty
don't be wrong, despite the poor performance of Gerald Sklar it's a buy at these prices. jmo and glty
lol, the liar Gerald Sklar, his family and Dror "Puppet" Moradov could play all in a circus, a real joke with these clown, lmao.
Please shake the old Gerry, he is killing both stocks by his behaviour, goooooooo Xuan.
yup Taki, it's that simple, Gerry Sklar has promised alot of things on PMRX and then stay silent for months, it's innaceptable and a behaviour of a crook, he can get f*** with his WMTG, he should remedy to this situation and quickly.