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Agree with you except for #3
Yep. I'm sure we both wish JT had taken whatever offers he had for AMRN when it was trading in the teens and 20s.
We need one more team to have an even number for FF
Reply or PM me and I will assign the last spot to you.
They're not valued the same.
AMRN Market Cap: $4.20 x 388.67M = $1,632MM
IFRX Market Cap: $3.90 x 26.17M = $102MM
Therefore, Amarin's stock is valued approximate 16x greater than IFRX's stock.
FANTASY FOOTBALL
DRAFT WILL BE WEDNESDAY 9/9 AT 6:00 PM PST.
I sent invite reminders to everyone who played last season via email. If those teams don't sign up by tomorrow morning, I will open their reserved slots to be available for anyone to join tomorrow morning (~11AM PST). I will post the link to the league then and sticky it.
Sorry for the short notice... life has been pretty busy.
I won't be watching the games... I didn't really think about doing the FF until someone sent me a PM about it. I don't mind doing the FF (i.e. I still play NBA 2K and Out of the Park Baseball video games).
Yes. My dad as well (different insurer). He hasn't does his appeal either.
Didn't have a problem getting the PCP to write it. Cigna has their head up their butt... and I think my dad is on Anthem.
Interest in Fantasy Football
JJPow asked me if I was going to run the league again (sans the 2QB fiasco). Are people interested in participating again?
Yes they were posted last year. I have been off V since January, however, getting my numbers tested again next month. Insurance refused to cover it so I am going to use all the info to write a letter petitioning that they do. I can say that I've regained some weight, and my skin isn't as healthy as it was before.
as long as this happens before January I'm a happy camper.
Yes I'm familiar with the migraine drugs... not super familiar with covid. I invested based on Oli... the rest is bonus.
Follow up with your own DD but:
$1.5B market just for Oli (ignoring remaining pipeline). Oli is better than morphine in the following ways:
1) No shortage
2) Less dependency causing
3) Less chance of OD
4) Doesn't affect breathing as much
5) Doesn't constipate you as much
FDA APPROVAL
https://www.prnewswire.com/news-releases/fda-approves-new-opioid-for-intravenous-use-in-hospitals-other-controlled-clinical-settings-301108621.html
SILVER SPRING, Md., Aug. 7, 2020 /PRNewswire/ -- Today, the U.S. Food and Drug Administration approved Olinvyk (oliceridine), an opioid agonist for the management of moderate to severe acute pain in adults, where the pain is severe enough to require an intravenous opioid and for whom alternative treatments are inadequate.
Olinvyk is indicated for short-term intravenous use in hospitals or other controlled clinical settings, such as during inpatient and outpatient procedures. It is not indicated for at-home use.
"Addressing the opioid crisis remains a top priority for the FDA. We will continue to do everything we can to reduce the number of Americans who are addicted to opioids and cut the rate of new addiction through a number of cross-agency initiatives," said Douglas Throckmorton M.D., deputy director for regulatory programs in the FDA's Center for Drug Evaluation and Research. "Importantly, the FDA will only approve new drug applications, including those for opioid medications, following a rigorous review to evaluate the risks and benefits and ultimate determination that the data support safety and effectiveness. Of note, this particular medication is only indicated for use in a controlled clinical setting, meaning under medical supervision and not for use in a take-home prescription."
A total of 1,535 patients with moderate to severe acute pain were treated with Olinvyk in controlled and open-label trials. Its safety and efficacy were established by comparing Olinvyk to placebo in randomized, controlled studies of patients who had undergone bunion surgery or abdominal surgery. Patients administered Olinvyk reported decreased pain compared to placebo at the approved doses.
The safety profile of Olinvyk is similar to other opioids. As with other opioids, the most common side effects of Olinvyk are nausea, vomiting, dizziness, headache and constipation. Olinvyk should not be given to patients with significant respiratory depression; acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment; known or suspected gastrointestinal obstruction; or known hypersensitivity to the drug. Prolonged use of opioid analgesics during pregnancy can result in neonatal opioid withdrawal syndrome.
Olinvyk carries a boxed warning about addiction, abuse and misuse; life-threatening respiratory depression; neonatal opioid withdrawal syndrome; and risks from concomitant use with benzodiazepines or other central nervous system depressants. Unlike other opioids for intravenous administration, Olinvyk has a maximum recommended daily dose limit of 27 milligrams.
The FDA granted approval of Olinvyk to Trevena, Inc.
Yeah I've been in since 2018. I am optimistic.
I think that's the low end. IMO I had a PT of $9 to $11 before the Adcom fiasco. If we get above $3 within the next two weeks (prior to approval), then I think that PT still stands... if we're at $2.50 or so (due to the dilution over the past couple of years), then maybe $6-$8 is more likely... but added value has been created via the COVID drug and other advancements in the pipeline.
Good question CBB. I'm trying to figure that out myself. There's so many questions & potential with Trevena's pipeline and with the COVID drug (which, wasn't even a thing 6 months ago!).
It may come shortly before (or shortly after). But it will be good either way, imo. Also the COVID drug top line results are expected in the next 4-5 weeks.
Pfizer switched Morphine production to Oliciderine at McPherson plant in Feb 2020
“Pfizer has a shortage of several prefilled syringe products, including morphine, starting in late-July 2017 due to issues at a manufacturing facility. Pfizer discontinued morphine iSecure syringes in February 2020.[3]”
https://www.ashp.org/drug-shortages/current-shortages/drug-shortage-detail.aspx?id=41&loginreturnUrl=SSOCheckOnly
Pfizer is a major morphine manufacturer in the US... they discontinued their morphine syringe production THIS FEBRUARY in their Kansas manufacturing plant and started making Oliceridine in the SAME FACILITY.
Why, when there’s already an IV opioid shortage? Could it be that they’re anticipating a superior and more easily produced analgesic to hit the market soon?
The below article is a good read about Pfizer’s morphine production problems.
https://www.beckershospitalreview.com/supply-chain/pfizer-s-opioid-filled-syringes-hit-another-manufacturing-snag-6-things-to-know.html
HT to @traderofitems on stock twits
https://stocktwits.com/traderofitems/message/231424818
https://stocktwits.com/traderofitems/message/231422993
Done
Agreed. It's good news.
All, sorry for being MIA... will try to be more present in the future, have a lot going on outside of AMRN. When we lost the court case, following things moved much lower on my list of priorities. That said, I still maintain the same positions I did before that bad news.
Zu is correct:
Assume you have a net sales price of x for europe:
US net sales price is ax where a<1 due to this judge's decision.
You have n units, and n will satisfy either US market (net sales = ax/unit where a<1) or EU market (net sales = x/unit)... FDA / US DOJ cannot force you to take a lower net sales and sell here at expense of EU market. The US government cannot force a company to conduct business.
I agree with you and LBL -- with the exception of China. China is a shithole tier country and patent protections there are laughable. F eddingpharm, China needs to be frozen out as well.
Thank you.
No idea, unfortunately.
I will let someone else send it to them... I've fallen out of contact with IR over the past 4 months.
This ruling will stymie innovation in biotech (especially cardiology)... very unfortunate. Hopefully, it can be appealed and overturned, but I am not optimistic.
fourth word in.
tbh would not be surprised if this call is postponed and replaced with another one tomorrow.
Amarin was not the defendant.
We won infringement but judge ruled that the patent was obvious so didn't matter.
No. Plaintiff.
man what bs.
Bob, having same problem with Cigna.
Gshall