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Thanks, all positive situations for DCVax combination therapy and hopefully great results for cancer patients!
Do you think the completion date might have been moved up so significantly due to extraordinary response or possibly quicker than expected recruitment?
Other ideas why 8-9 months shortening of trial milestone?
Well it was a hypothetical question regarding MAA outcomes, nes pas?
MAA approval is certainly exceedingly important, however it may not, hypothetically speaking, be necessary and sufficient to BK Nwbo although it would be a terrible set back for sure.
Again hypothetically, nwbo has assets of value such as Intellectual Property and the FlaskWorks derivatives, as well as potential opportunities to continue the various promising combinations trials with partners, or other less than optimal outcomes.
However, imo the MAA should be approved because DCVax L extends the lives of GBM patients and cures some significantly more than any other GBM treatment and rGBM treatment (which there are no other treatments for) especially!
So the other side of the hypothetical outcome is approval and a game changer!!!
I believe approval is more likely than not considering all the due diligence that has been shared on this message board.
When I was getting restricted shares and options on the company every year I had enough skin in that game that I didn’t want to keep adding more either.
A little diversification don’t cha know
Yes, but this time it’s different
Really!!!
Hey, if they could bring back Bobby Ewing on Dallas with a dream scene, a share price bubble should be easy
I also remember:
The phase 3 won’t complete
Data lock will never happen
The endpoints won’t be met
There isn’t a peer review journal paper
Ok, but the journal paper won’t be published
Ok, it won’t be published in a high standing journal
Ok, but the peer reviewed high standing journal paper is inconsequential according to doctors who are compensated by a helmet company
There won’t be a SAP
The MAA will never be filed
The MAA won’t be validated
Now, there won’t be MAA approval nor NICE blessing…..
I see a pattern of negative narratives that get superseded positively and subsequently new negative narratives being asserted…
I also see completely shenaniganned share price/trading patterns that in my opinion are controlled by shenanigan doers, imho.
I’m sticking with my conviction that nwbo will keep achieving the milestones and working their (close to the vest) plan to successfully bringing a new treatment platform to cancer treatment and the long awaited return on investment!!!
Soon, I can replace the alarm clock with a french maid gently tickling me awake with feathers - ooops I must still be dreaming
The maid thing is fantasy but the efficacy of dcvax (and especially plus Hiltonil and your favorite pd1) is science and empirical evidence!!!
Do you hear someone saying “here comes the judge, here comes the judge, order in the court room cause here comes the judge!!!”
Amen !
We may be suppressed, oppressed, and depressed, but we shall overcome, someday (soon!)
To the moon!!!
M-A-N-I-P-U-L-A-T-I-O-N
If not for the shenanigans the sp would already be $5-$10 prior to approval imho !
It couldn’t come from a nicer, most deserving bunch, I said tongue firmly in cheek
Yes, indeed!
We’re probably going to miss all the FUDsters…..NOT !!!
It is coming!
It will happen!!
Approval is on its way and inevitable!!!
Resistance is futile !!!!
Denial is a river in Africa!!!!
One fine morning soon we will wake up to the glorious news from across the pond!!!!
A new era in immunotherapy is upon us!!!!
An all shares BO by a strong acquirer paying steady, secure and growing dividends is a recipe for a generational trust fund.
Buffet collects wonderful recurring dividends from the likes of Coca Cola and American Express and others that were purchased several decades ago for less than a tenth of current share prices, and annual dividends that have grown and compounded very significantly!
We disagree with your perma-negative statements.
I would have said beliefs however I don’t believe you believe your own statements, just doing your job imo.
Are you taking into account that revenues at something like 150,000-200,000 pounds per patient will start after approval?
Also, combination trials and licensed trials and licensing of the dendritic cell technology and potentially even Eden automated closed system production technology fees!
Approval will mark the new beginning!!
You are plain wrong.
The survival is not accounted by outliers and you should know that.
Try looking at survival curves for GBM and find how many outliers there are at 10 years.
Btw DCVax happens to provide the best response to the subgroup with the worst survival prognosis.
I’ve jousted enough with you and it’s been suggested that it’s a waste and abets your objectives so I will not continue replying.
I’m not on the board as much as I usually am, and there is limited new due diligence as we wait for approval and the MTD ruling.
So if I can counter some FUD with facts and possibly lighten things up a little, for a grand total of maybe 15 minutes on days I post something, then maybe I’m helping.
Connecting with people, even by message board and even finding some common ground or tolerance with others having different agendas, feels healthy to me at my age and retired status.
I realize full well the FUDsters agenda and that my posts won’t change that, however adversaries do sometimes maintain a certain level of de tant (sp?) and slivers of common ground.
If I offend you I am sorry and if others feel the same I may see the error in my actions and possibly limit self expression and message board social interaction, but I’m not a young dog and not easy to learn new tricks
I know, I spent more than 15 minutes on this post alone.
In other words even for AI it’s garbage in equals garbage out!
The better the training data the better the AI performs in general.
I can get a headache thinking about using biased training data by entities that want their AI to reflect their biases and measures of their particular definition of success or correctness.
So once again good people can use good technologies for the normative and moral/ethical good, and bad people can use good technologies to achieve bad normative outcomes, not unlike the manipulators and fudsters use of HF trading systems and message boards towards their ends and against our righteous due diligence based investments.
Denial is not only a river in Africa
How can you deny the science and the living proof of a growing systematic number of people who have lived far beyond their prognosis for such an unforgiving disease as GBM???
Boggles the mind!
The direction is definitely personalized medicine, and dendritic cell vaccine made from your own dendritic cells and tumor is about as personalized as you can get!
The Hiltonil enhances the immune system T cell quantity and quality (less exhausted immune cells) and this baseline component works better than without the iCLC, and engenders further efficacy when treatment combines other treatments/components such as CarT (keytruda or others) and more to be determined!!!
Enlisting and enhancing one’s own immune system to perform its inherent functions is the key to effective treatments that don’t attack your normal tissues!!!
But this is preaching to the choir.
Now we have our own twilight zone series scripted by the FUDsters and their employers, with bizarre narratives and cringeworthy absence of conscience!
Monday, Tuesday, Wednesday, Thursday,…
Michael….
My next car will have remote start and drive over.
Can’t be too careful!
Irony was not lost on that show!
Although I don’t remember the details, the episode I think of often when thinking about the show is where doctors and nurses are working on a female’s face and when they take off the bandages they are aghast. I think the twust was that the woman’s face was what we would consider beautiful but when the doctors and nurses took off their surgical masks they all had pig-like noses. All about what is the societal norm I guess.
Nahhh, she’s a sweetheart, as long as she’s not angry with you…. Then Putin is a pyker and gentle in comparison
We are both from southern Italy, Sicily and Calabria, and known to be an explosive combination. Hot headed and hard headed are typical characterizations!
And like the alleged shadow organizations of these regions, once in the family nobody gets out alive as in divorce Italian style
Speaking about Russia, please add the following:
Stay away from windows and high places in general!!!
It’s amazing how many “acquaintances” of the state seem to have developed balance issues and happened to gravitate towards elevated openings although loss of life is not funny.
Perhaps another synergy between RPC and nwbo is their inclination if not full commitment to advancing cancer research and treatments!
Merck is a great BP (full disclosure: I am long) and has a strong commitment to research, however it also has other aspects to consider and drive their decisions and paths to navigate through while not disappointing Wall Street.
There are worse partners and fates than hooking up with Merck, and personally, winding up with a fairly large amount of additional Merck shares (with their dividends) would make for a great retirement asset and legacy for generational wealth.
If you trust LP especially, and LG, to make decisions aligned with the greater good as well as their own good, which is aligned with shareholders by virtue of large share equivalent holdings, our interests are in committed hands and to bring back an old expression, LP plays multidimensional chess!!!
I look forward to meeting you and other Atlanta area nwbo longs especially to celebrate and enjoy the fun and prosperous phase of our committed investment and belief in the science!!!
I forgot another tip:
Order your meals semi randomly alternating between Uber Eats and Doordash and track the delivery, meeting the delivery person at the door for a direct handoff. Sprinkle in some self pickups to further vary the pattern.
Always wear your Apple Watch and setup 911 and emergency contact alerting. Keep ipicac and overdose medication in the house and donate generously to your local emergency ambulance squad, police, hospital emergency room and keep her away from your doctors
This is all in jest, i mean we wouldn’t stand a chance if they really wanted us out of the picture
Check that no knives are missing, don’t keep firearms and ammo accessible in the house, and never take the first sip or bite of meals or snacks, or drink from open containers.
Alternatively or in addition, make like you’re offering the same food to her pets in plain sight she would never endanger her pets!
Be vigilant for new or changed life insurance notices.
One more tip: when in doubt spit it out!
It would not make sense to learn that a combination yields greater efficacy than without (iCLC) and not utilize the same.
This will also be the case for extended combinations such as with Keytruda, where the combination might boost response to far above previous levels, such as >60% for GBM, when Keytruda alone hasn’t shown significant efficacy.
This same greater than the sum of its parts efficacy may play out against other cancers and other components, benefiting and enabled by the DCVax platform treatment!
I would do a similar thing, getting some needed cash out and letting the majority grow to true value and become a major entity like a BP.
Thank you and celebrate we shall !
Not that philanthropy is a bad thing in any way.
Is it philanthropy to want to advance our odds against cancer?
And when it strikes personally is it philanthropy to want to survive longer and with better quality of life? Or as self preserving as possible?
But you’re right, you got me pegged. I’m the kid that would choose kids for my team in the school yard with consideration for every one’s feelings and dignity, not the guy who only cared about winning. Sure, sometimes we lost, and sometimes the victory was even sweeter against the winning is everything team captain.
In my management career I also strove for team successes trying to help achieve success by providing the best support, environment, and coaching of the team. Nobody gets thrown under the bus and nobody gets left behind. Everyone can contribute how they best can.
So no, the ends do not justify the means.
I do not want blood money and money isn’t everything. Integrity and respect are important characteristics.
Did any of this get through your apparent tough making money is it, whatever it takes and whatever collateral damage it may cause, persona?
Finally, have you lost a loved one, a direct close family member, or have you been treated for cancer?
It sucks! Ain’t nothing redeeming or satisfying up close and personal. Especially in the case of young innocent children!!!
Have a heart man! It won’t kill you and you might be a better person for it!!!
All’s well that ends well!
I think we have been patient enough and anxious to start the return on investment phase!
I’m not greedy, I’m ok wetting my beak
Look, truth be told, I wasn’t crazy about the mention of the concept of nondilutive management compensation awards.
I’m not sure what the reality was, however I’ve worked in big corporations and have seen “compensation plans, bonuses, options repricings, etc” that always seem to have outsized benefits to the higher ups, and even some benefits at my former levels, so we all live in glass houses so to speak.
The management structure of the FUDsters employers have similar outsized benefits at the top levels, just a much more serious severance package
Seriously though, I would love to have a great return from the nwbo investment but honestly the benefits to humanity of making a breakthrough advancement in the fight against cancer, that has taken our dearest loved ones and friends and all peoples, is the much more important return on investment.
We are all subject to the suffering that cancer inflicts indirectly and directly.
I wound up buying much more than I expected but I’m a sucker for sales
A long time ago, even by nwbo standards, I did a similar average down with Sirius shares, although I was too chicken to back up the truck at 10 cents per share when BK was looking imminent before Malone came out and made Sirius the offer they couldn’t refuse that eventually led to a de facto change of control to the Malone empire.
I did fairly well eventually selling half my shares and still have the other half well in the green even at current $3 share price.
Nwbo is my last such swing for the fences and if we’re all not crazy, it’s going to be a grand slam imo.
If not, I may need to hire a bodyguard and food taster
A start is operating on actual events, results, and peer reviewed data and conclusions.
I don’t want to get political, however you know the type that just makes stuff up that supports his objective at the moment and swears by it regardless of the solid facts.
Did Rod Serling give you the creeps?
He gave me the creeps.