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You’re a short timer compared to some of us looonnngggsssss!
It could very well be worth the wait!!!!
The dilution FUD is nonsense!
Everyone who knows stocks of pre commercial companies knows to factor in the float and all the options and shares still available to sell per our current registration.
So the trickle of new shares is already accounted for, unless a new registration is issued.
And we longs are expecting valuations of nwbo in the not too distant future of $20B-$30B, so if you were even to assume 2 Billion shares rather than the current float of 1.2 billion shares, you get sp of $10-$15.
LP was also in a different part of Enron, one that wasn’t involved in the shenanigans and one that was well thought of, if memory serves me.
Agree that first approvals are job 1.
All else will be enabled by the first approvals, including the combination treatments, and the tissue collection will continue organically and build up over time as will the raw data, with the value increasing in kind.
AI technology is also advancing by leaps and will be applied to every field and endeavor. NVIDIA is already involved in drug discovery and I could easily see involvement in helping to identify the more promising combination treatments from the large number of possible combinations, as one potential example.
The mrna approach lacks the immune memory of the DCVax approach because mrna vaccines cause temporary production of disease fighting cells whereas DCVax produces long term memory in the immune system.
Here’s another thought, that with the tumor tissue that nwbo has been collecting, if all the samples would be genetically sequenced and also analyzed for antigens that are present, big data AI analyses could be performed that could yield vast keys and correlations that would shed light on similarities and differences among cancers and tumors and point to the promising strategies to explore.
Nwbo can go to town themselves on the data, with strategic partners, and/or licensing/usage arrangements!!!
Celularity is reportedly doing something similar with their umbilical cord blood and cells, and placental tissues.
I’m looking forward to seeing how far and wide the DCVax platform and especially Direct will go!
I truly feel the great elegance of dcvax in modulating the immune system such that it does what it has evolved to do, but tuned to optimize it against abnormal “stuff” while not causing harm or distress, is going to make a positive impact on many cancers on it’s own but becomes the Coca Cola of cancer treatments as in “everything goes better with Coke”!
Thanks Bio,
I suffer more senior moments lately where I remember subject more or less but struggle to remember details like names and titles of people and things, so I really appreciate you helping with the specifics!
It’s funny though, I’m able to name all these songs from the 60’s to more recently on X in response to a few posters that post “name the song” tweets (are they still called tweets or are they exes now )
At one point in time, maybe as far back as 5-10 years ago, I think I remember reading that tumor load was a factor in survival but in the sense you wanted to get as much of the tumor out thus leaving the DCVax with a less challenging sized tumor.
A lot of time has passed and experience has been gained, and I don’t really know how sensitive survival is thought to be today depending on tumor load.
Also clearly today it’s felt combination approaches are required to improve overall response to treatment. Sort of like how HIV cocktail’s evolved, DCVax in combination appears to improve response and survival significantly!
You can take me out of Brooklyn but you can’t take the Brooklyn out of me
It’s streets 101, fight fire with fire, tit for tat, crazy with crazier (like a fox), but no mothers, wives, or kids, unless you’re ready for all out warfare.
But under the right circumstances you can take part in a battle of mother joke rank out sessions (if you don’t take it too far and too maliciously)
Ex-actly debunks Ex-uberantly negative oriented Ex!
Come on Ex, you can still come to the pro DCVax/pro nwbo side, and it would be good for you to be positive for a change.
If you load up on nwbo at current sale manipulation induced prices you might make a lot more getting long than whatever you’re being motivated by in your present negative narrative schtick!
Wouldn’t it feel good to anticipate great uplifting events instead of fomenting doubt and fear?
Some of us would forgive you I think.
Light - good! Darkness - bad!
You seem to have a thing about arses and arseholes, but to each their own.
If I were to engage in your level of insult, I would call you a smelly dirty taint!
But I try to take the high road, and stick to truths or what I believe to be reliable due diligence.
From copilot:
“Health Canada prioritizes the review of newly approved treatments to facilitate earlier access for Canadians. While the UK’s Medicines and Healthcare products Regulatory Agency (MHRA) has established new recognition routes for medicines using approvals from several international partners, including Canada, the process in Canada still ensures adequate evidence of safety, efficacy, and quality before granting approval123. The goal is to provide patients with safe and effective treatments while maintaining rigorous scrutiny and quality standards. Additionally, similar efforts are underway to establish recognition routes for medical devices1.”
So I take this as yes Canada tries to expedite by prioritizing treatments that have been approved elsewhere like the UK, and perhaps it’s not yet universal recognition for approval in the directionfrom UK to Canada.
Nonetheless there is a new multi agency route for approvals, however we do not know that it has been pursued by nwbo, although the multinational structure of the phase 3 trial and the single SAP and maximally common marketing approval applications approach aligns with at least simultaneous or overlapping approval applications.
Grazie, buona Pasqua!
Your nose is growing with each falsehood!
You have to stop Geppetto from pulling your strings imo. Just friendly advice.
Ciao paisano!
Che mi dici?
Allora e il orario di DCVax!
Salute
Best wishes for a speedy recovery!
Happy Easter!
I disagree with Ex. The question wasn’t limited to automatic approval but faster approval and facilitated approval.
And it’s also possible to utilize the multi RA submissions program, which name I’m not remembering but other posters surely remember.
Note that at a minimum, nwbo specifically used one Statistical Analyses Plan and the Phase 3 trial was multinational (US, UK, Canada, EU) with sites and patients enrolled across all these countries.
Yes, there are!
Canada fast processes the applications that the UK approves.
The EU should also be facilitated.
There are multiple approval routes that exist and might be used to facilitate and speed approvals by cooperating countries, including the USA.
Approval by the UK would also put pressure on the other regulators to provide clear and strong reasons not to approve or risk their own reputations and backlash from patients who will want access to DCVax especially because DCVax is exceedingly safe and doesn’t degrade or harm patients health imo.
If you look at what posts have been stickied here you can get a good overview of nwbo and dcvax.
For further reading you can look at X posts by bio99 and Baxe. Baxe did a stupendous treatise all about nwbo and dcvax that would be a great overview by itself.
Then you can find and read presentations such as the one presented May 10, 2022 at the NYAS (NY Academy of Science) and Dr Marnix Bosch presentations regarding Method of Action of dcvax and other ASCO presentations, and much, much more!
Jumping ahead to current events, Nwbo submitted a Marketing Approval Application to the MHRA in the UK for approval of dcvax-l for new and recurrent glioblastoma multiforme and the approval decision could come from any day now to less than 3 months.
A case was just made by a poster that given MHRA newsletter noted applications for 150 day consideration submitted late last year would be “upgraded” for a now shorter approval process, the approval decision could potentially be made within the next 10 days. The MAA for DCVax-L was submitted December 20-21, 2023 and would therefore fit the bill.
The endless FUD postings are relentless and getting worse as progress has been made, and nwbo has initiated a law suit against more than a handful of Wall Street market makers for allegedly spoofing (manipulating) the nwbo share transactions, however the shenanigans continue imo.
This is a good time and price to initiate a position in nwbo imo but that’s not advice and please do your own due diligence before committing money on any stock or not. I am one of the looonnnggg time holders and accumulator of the nwbo shares and for myself I believe the current risk reward ratio is compelling given the still low share price and waiting for approval or not of the MAA after a successful phase 3 trial and a peer reviewed paper on the same published in one of the premier medical journals.
What I just posted is a start for you however please do the noted reading for better due diligence and regardless, don’t get in over your head like risking money you can’t afford to lose in any pre commercial pre earnings stock imo.
Nicely done!
The FUDsters must be trying to figure how to respond to such a powerhouse positive, yet simple to comprehend, post!
There might have been something in the water or subliminal messaging because many of us that grew up in the later 1950’s and 60’s in Bensonhurst, especially male children of Italian immigrants, such as my 2nd-3rd cousins and paisons, mostly earned electrical engineering degrees.
Engineers were well respected in Italy, however I can’t say that my parents directly influenced me and my choice of career.
We did have strong math and science aptitudes in common and our fathers tended to be mechanically inclined. My father never completed elementary school however he became a licensed diesel engine man onboard commercial boats and taught me about diesel engines when I asked him how they worked when I was a kid.
But enough from me. Age is tending to make me tell stories.
Thank you, and we are witnessing the cancer treatment revolution away from chemo and more towards immunotherapies!
Yes, however trial results are not anecdotal, and neither will be the approvals!
We do indeed have a lot of common ground, and I appreciate the work ethic and all the moves. I traveled for work a lot but fortunately only moved a couple of times for new corporate (engineering) jobs.
It’s all good and best wishes to you, and I hope we all get what we want out of life and against the scourge of cancer.
I feel blessed to see just in my lifetime such tremendous human achievements and advancements such as going from vacuum tubes to the transistor to integrated circuits to large scale integration to the latest nVidia chips with hundreds of billions of devices, and all the uses that have emerged. When I started college the first four function calculator became available and IBM computers and peripherals took up full rooms of equipment. Medical advances also happened that were the stuff of science fiction. The AI era is enabling the next Industrial Revolution and will impact every aspect of our lives!!!
It would be great to add big breakthroughs in curing or treatments that at least turn cancer into a chronically treatable disease! There has been important progress against cancers and other diseases that were previously considered death sentences.
DCVax is so elegant, empowering our immune systems to do what they evolved to do with an important assist in finding the cancer cells and bringing a higher number of effective immune cells to the task of attacking the cancer!
GLTA
You are not well informed or just misrepresenting results and Doctors’ opinions regarding DCVax.
Have you listened to Dr Ashkan’s emotional pleas to make DCVax widely available, based on his personal experiences with patients he has treated or observed?
What do you say about the woman with Merkle cell that was told she had several months to live and to go home and prepare.
She was able to get DCVax and lived to see her young boys grow up and go to college. I think she’s still alive!
One more note, watching and caring for my mother during the four years (prognosis was for 2-3 years) she selflessly fought off the cancer that killed her showed me really up close and personal how little things matter in the end, and you can’t take anything material with you. She never complained, at least not in front of me, and I couldn’t imagine having a fraction of her courage and absolute love for me.
I lost my biggest fan and her dying regret was that she could no longer be there for me! That she was sorry to leave me alone!
DCVax might have extended my mom’s life or at least saved her from the progressively worse side effects of the other treatments.
That’s what many of us longs are supporting and investing in nwbo and dcvax!!!
Return on investment is also important as a practical matter and way to hopefully leave my kids and hopefully grandkids with a legacy for a better life!
So 100% in agreement with your sentiments
We have more common ground than you might think.
I also care the most about comfort, and I avoid being a walking advertisement for designers, thus avoiding garments with designer names prominently displayed. I was raised to prioritize quality, waiting to get fewer quality things than squandering hard earned money on many low quality and impulse items.
99% of my wardrobe was accumulated while working and prior to retirement, and I should be good with what I have going forward.
I’ve donated new and good as new items by the bags full every year, including suits, sport jackets, shirts and pants.
My parents gave me a great middle class life, immigrating from Sicily without jobs and a place to stay, living in a friend’s basement for a couple of months to find work and move into our first small apartment above the children’s clothing factory that my mother found a job in, while my father worked nights on the docks and cared for me during the day until I was old enough to start and get to/from school and could go downstairs to my mother in the clothing factory.
By the time I was in 3rd grade my parents saved enough to buy the 3 family house that they lived in until their deaths in a very decent blue collar neighborhood in Bensonhurst/Gravesend.
They raised me there to be respectful and prioritize the important things in life, get a good education, and above all that we were as good as anybody and that I could accomplish and become anything I worked for.
These humble people made a good life for themselves, ensured I had their total support and trust throughout my life, and not only left me a substantial legacy, but also left their grandchildren resources to apply to their needs, including college and what little medical school tuitions I didn’t pay myself, and for down payments on their homes.
So don’t go painting me and my heritage as foolish spenders to be taken advantage of like “a salesman’s dream.”
I assure you that I absorbed the life lessons of living in Brooklyn and NYC, haggling with the best of them on Orchard Street, negotiating and walking away from deals of all sorts on everything including furniture and new automobiles (for me and my kids, since my parents bought good resales from people, not dealerships for themselves.)
I’m glad to say my kids learned these lessons of honest focused work and are tougher negotiators than we are today.
So I’m not your fool, and I grew up on the streets and among those who chose more “enterprising” professions, probably some you and your FUDsters may indirectly work for, and being from Sicily I understand “these things.”
Maybe you touched a nerve with your accusation of my foolishness, but hopefully you now know better where I’m coming from, and you go do you and don’t “worry” about salesman’s dream me.
Capisce?
3HeadedDog speaks with sophisticated tongue. Nicely done! Poltroon, classic word.
I paid less than Ralph Lauren sale price for Brunello Cucinelli. And the Brunello pants are the most comfortable I’ve ever worn. But I never pay regular or even sale price, I buy when I see deeply discounted high quality goods. It’s value investing
They are quality wool pants, not polyester.
Besides have you gone shopping anywhere lately even for non designer pants? Don’t get me wrong, I’ve had plenty Dockers and they did the job for work a day casual office wear.
Anyway the Polo and Boss goods that I buy for the same prices as cheap goods hold up great and look great for a long time, unlike the cheaper stuff that doesn’t wear well and gets phugly. Same goes for shoes. You’re better off buying smart.
You got to know what you have, like nwbo and the breakthrough that is DCVax !!!
That’s why Wall Street with Michael Douglas and the Sheens is such a great movie.
It highlighted the power and value of inside information and even just working real hard to do detective work to infer educated guesses!
Although a tad early, it’s close enough to say that April showers bring May flowers!!!
Hey, I had paused buying any more shares since I was pretty much all in already, but sub fifty cents has brought out the deep discount buyer in me. I never thought this opportunity would happen while waiting for approval.
If the sp continues artificially lower there’s no way I’m going to resist some larger new purchases in the absence of actual real negative news.
Did I mention my wardrobe of all new high quality items has all been bought at deep discount. $750 pants for less than $100, $1,100 shoes for less than $300, $1200 cashmere sweater for about $80!
I know deeply discounted quality and nwbo is deeply discounted quality that already should be in the $10 range if not for the manipulation in my opinion!!!
My mother survived colon cancer at the junction of her small and large intestines at the appendix 16 years before her fatal cancer.
When she was treated for the colon cancer the surgeon took out the appendix and some small and some large intestine, and rejoined the intestines.
This was a major abdominal surgery and required a number of days to recover from. My mother was able to withstand a lot of pain, so although she had the morphine button available she minimized the use.
The point being that that was major and required over a week to get to the point of leaving the hospital.
Afterwords her oncologist at that time treated her with 5Fluoro something chemo as a safety measure.
Princess Kate’s situation strikes me as sounding similar, but of course it could be something completely different.
Just my two cents, and whatever the Princess had, my prayers and well wishes are with her.
I probably spend less than $40 per year on lottery tickets since I only buy them when the jackpots are huge just to participate.
The odds of winning the jackpot are more than 200 million to 1 I think.
I think you have a better chance of being bitten by a shark while simultaneously being struck by lightning, or some such crazy occurrence.
Better yet I can buy 4 shares of nwbo at current price instead of 1 lottery ticket and stand a much, much better chance of getting my money back with a bonus.
Thanks, sometimes I can still communicate a point or two, instead of my usual sophomoric humor that I pass the time with while waiting for DCVax L approval!
Ain’t gonna be a reverse split!
My odds with nwbo are millions of times better than the lottery tickets I occasionally buy.
Waiting on approval after a successful phase 3 trial, certified manufacturing, and approved PIP, while allowed to treat patients in the special’s program has got to be many orders of magnitude better than the >200 million to 1 odds of a mega lottery jackpot, don’t you think?
Maybe I am delusional but I seem to be in good company and the accomplishments to the doorstep of first approval are undeniable as real!
I understand completely!
GLTA
I’m hooked on the Oak Island show and I think I can guess how the various discoveries and constructs they have found tie together.
Funny, but my wife poo poos my interests in both Oak Island and nwbo.
Your stock is not going to happen.
They’re not going to find anything on Oak Island.
What I see in common is the progress and discovery that already will change cancer treatment and North American and European history!
I may not be able to share in the treasure of the Templars and British sunken treasure recoveries that may be present on Oak Island, but I do have a chance to make a return on nwbo stock and as a member of the human race that has been afflicted with terrible diseases.
I think nwbo will come in before the Oak Island treasure however I absorb and appreciate both journeys and root for them both!!!
I appreciate your points, I really do, and I question myself frequently to keep things in perspective and not bet the ranch.
I’m more concerned about the financial commitment I’m locked into in building our new forever home than any of my other investments, including nwbo.
While I have invested a considerable amount of money in nwbo, it still doesn’t come remotely close to jeopardizing our standard of living.
I would greatly regret losing my investment in nwbo, no doubt about it, however I would also regret walking away from an investment that was much more of a gamble 13-14 years ago when nwbo was only 10% up Mount Everest.
Now that nwbo is 10% from the summit and managed to overcome 90% of the perils of climbing Everest, with a lot of respect for the mountain that can still suddenly dash nwbo’s journey, there is also the growing confidence in surviving the 90% and being within a relatively short distance from the summit with the energy and skills and wise sherpas to reach the peak!
LP and company is steps away and the only thing remaining is the actual approval of a submitted and accepted MAA in a country that has approved manufacturing and the PIP and has allowed treatment under the specials program, with a consciously known GBM issue that has taken beloveds in entertainment and government.
Yes, any investment includes an element of gambling, however despite the best efforts of foes and heartless greedy elements, including the paid mercenaries who post FUD here and elsewhere, the risk-reward seems better than ever despite the artificially manipulated and low share price!