LOL, Seaman Schmuckatelly can find us 50 ft of gig line to batten down the hatches for the short storm that is brewing. Only so many "short" life vests available.

There goes the goal post move. To me this is a genrral concession that approval will happen. Thanks for that. And blah blah blah. These shorts are like Bagdad Bob. Next you will tell us that the nature of this process isnt applicable to all solid tumors. The pattented method B will bury the shorts.

Hmm the patients with the worse prognosis performing the best(must be placebo). The more agressive cancers probably wouldnt be noticed by a supercharged immune system. That agressiveness helps them hide right.?

In all seriousness it reminds me how checkpoints work better with more agressive tumors that have greater mutational burden. In other words it makes sense that DCvax would work with tumors that stick out like a sore thumb.

First it was this will not help patients. now its, Nice won't pay, next it will be no will want it even it if its approved. DNDN playbook to a "T"

The science shows that this has a benign side effect profile and that the sicker patients are responding better. This clearly shows they haven't cherry picked or got lucky with the Survivors. They also didn't over power a trial like BP would have to get a false P value. Their P values are impressive with the number of data points.

Mesenchymal, Mesenchymal, Mesenchymal. "Marsha, Marsha, Marsha":


By the way every trial, every single trial is not perfect or without any biases. Unless you have 300 cloned humans, fed the same same diet, raised a bubble you are not going to have a perfect trial.

The benefit outweighs any risk. They have shown that lysate pulsed DC cells can uptake and present antigens and these matured APCs can direct other immune cells to not only acquire the targeted antigens(Multiple) but also travel to the site of the tumor and mount an immune response. That immune response and the magnitude of it predicts survival based outcomes (a very objective measure) you are either dead at 36 months or you are not. There is no gray area. They have also through advanced imaging come up with diagnostics that helps predict the magnitude of response a patient will have based on characteristics of that patients immune and also have ways of overcoming challenges for those that do not respond with already available and approved adjuvants.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689101/

Cancers ability to become metestatic and spread will be its Achilles heel.

They are so on to something with this and method B or Poly ICLC and Vax L

Hypoxiate the tissue(dont laugh but avasitin might help), cause the EMT kill it with DC vax (properly activated).

I'm sure they will be able to indicate a response now.

https://assets.researchsquare.com/files/rs-2591941/v1/e919e1be-d41a-4927-8519-9a570ee640be.pdf?c=1676909716

Wonder if MRK is involved?

Right. Like they couldnt hyperactivate L like they did direct. Like baking bread. Too short its doughy to long its burnt. Same thing with maturing DCells. Not all Dendritic cell therapies are equal. The precise recipe that is patented with essons learned from the trials should pay dividends in the fight to provide safe but highly effective targeted therapies. If it wasn't special they wouldnt have gone through the trouble to patent it. High Octane DCVAX on tap.

Next it will be... But dcvax will not translate to any area of the body like a checkpoint inhibitor. LOLs. Or it's too expensive like dendreon. LOL That was solved too shorts.

You see this is what these people do. They truthfully lie. Of course initially ORR will not show what you want it by previous methods of measure. "Well the area of the tumor appears to have grown". Of course it has, that is what you want it to do if you want immune cells at the site of the tumor and it is not indicative of a worse prognosis. LOL at ORR

https://www.pnas.org/doi/10.1073/pnas.1706689114

Man Doc I don't know this patient lived 10 years longer than he should have but according to ORR he should be dead because the general area of the tumor increased, but some how he is still here after it subsided. Do you think our measuring tools are wrong?

lol Not with the old diagnostics. They now however have a way of identifying actual tumor vs TILs vs Macrophages, etc etc.

Doc what was the turn around time from MIA to approval on the other two? Was it 90 days?

If the helmet worked so well wouldnt continuing patients continue to grow? No offence to patients looking for every way to fight cancer but I just dont see the optune device to be the best long term option.

You dont have patient compliance issues with DCVAX. Once injected its worn 24 hours a day.

Becuase there is just a ton of other treatments out there that work well for recurrent GBM. Lol your argument is invalid

Maybe they are all cured :)

DocL. Are the 17 patients from the MRI study the missing 17 patients from the 348-331?

I didn't look that close but the 17 seems very coincidental. Maybe NWBO was working very closely with the FDA

Drugs are Bad MKAY. "High" personnel. CHATGPT much?

BOOM! Cause ---> Effect. So we can tell that an injection in the arm with DCVAX causes PSUEDO Progression at the site of the tumor. MOA. We can show TIL's which will be important with the CI combo's.

This is a big one IMO.

Application maybe can be made at the same time but the approval would require MIA first?

He must feel the value will be higher in the future. By gifting them now. He avoids a much higher tax penalty.

Submission to regulator will come IMO right after (meaning within a week or two) the MIA. So I do think we see a pop. MIA=More revenue for those seeking treatment before full approval.

Ding Ding Ding. Why would they not apply lessons learned along the way. Direct and L are same platform just tweaked. Antigens = Frquencies, Activation = Amplification. You need the right notes and enough amplification to shatter the glass. Id be willing to bet many of the 5 year survivors in L had some luck on the activation front. I like the idea of activating Tcells to inject with the Dcells too. A safer and more natural version of CART for lack of a better term. Let the APCs select the antigems, hyper activate them and expose them to tcells and then inject them all back in. Locked and Loaded.

Explain Mesenchymal.

Shouldn't the MIA be any day now. What is the general timeline. I actually thought it could occur before the end of the year but...

Horse DoDo. Unless you clone a person 300 times and raise them in the same environment for 30 years and then give them GBM, your not going to get perfect matches of patients within any double blind trial. So grabbing matched placebos for GBM in other trials is not that much different than the variations of individuals within a trial of this type of disease when the prognosis is well known. This isnt proatate cancer its GBM. You cant blindly pick ones that are going to live past five years and shove them in our DCVaX arm. All trials and even real world experience have already proven there are very few wild type GBM survivors beyond 5 years. The makeup of the survivors cant be explained by their age, etc. You cant placebo effect your way to outrunning GBM past 5 years. The recurrent GBM patients also prove this along with supporting documentation from other trials like LL combo trial. DCVaX is an active agent that prolongs life period.

Not sure it is cheaper or even more effective. Thinking AI can outsmart an evolved immune sytem, dcvax approach, that when functioning properly keeps cancer at bay in all of us is dumb. IMUC selected 7 antigens. Contrary to Adam Dipchits thoughts, the immune system and APCs are not "Dumb"

And existing intratumoral tcells is a prognotstic indocator for use with dcvax. Stupp and everone bitching about timing. One mone, two month enrollment really wouldnt impact those 25 that are still alive post 5 years. Maybe thats why they took down the video. She was talking about bringing up all xx numbers of patients. Maybe nwbo has more info to share about the info arm.

So you agree DCVaX wiorks better the more doses you receive. I think they showed that in the direct trial.

Explain the 25 alive at 5 years. Not an estimate. Many were older or mesenchymal which is a worse prognosis. They shouldnt be here but here they are. So you can just stop saying DCVAX doesnt work. It's obvious in spite of the trial confoundments. Show me a trIal where all participents within the trial are 100% the same both in nature and nurture. You cant. There are zero cancer trials particularly in solid tumors that are 100% exact. People are gentically diffetent and so are solid tumors themselves. The survival differences cannot be explained by chance alone. Therefore DCVAX statistically works. Period.

You can live without a foot so...

P1 trial normally not powered for stat sig but it just may hit it with a large enough delta. And all the drugs in the trial will already be approved individually when this reads out so its more about sequencing. Amd will be confirmatory. If the differenxe is large enough it will not meed much else.

LOL. Do you have any beach front property in Montana

Supply and demand. If you make more shares unshortable (less supply) and buy shares and more and more shorts are kooking to borrow with less available shares to borrow, the cost of borrowing will go up. With a few mouse clicks you can create a cash only non margin account with the same brokerage and transfer from 1 account to the other with a few more clicks and viola no more shares to short and borrow costs go up.

Not sure it will be so difficult to prove without the MM destroying evidence and individual employees complicit and lying under oath.

The fact that he commented on JAMA and has a competing treatment tells you all you need to know. They are SCARED. The lady doth protest to much.

He absolutely is. He disclosed he wasn't a "Shareholder" but he absolutely is a stakeholder.

He probably had a few of his patients ask him about DCVAX and he got a little pucker factor.

Doesn't NICE take into account QOL

https://pubmed.ncbi.nlm.nih.gov/18767894/

Again who TF wants to shave and wear a magnetic beanie attached to a ball and chain if they can avoid it.

Altmetric pushing 1000 at 971. This is early and just the beginning. Wait until the knowledge we have is transferred to the masses. Once they start understanding more about this platform and Direct method B etc, etc,. Keep posting, tweeting, and shedding light on the potentials of this platform.

Like a Wuhan lab leak, the shorts will not be able to put the tooth paste back in the tube.

https://jamanetwork.altmetric.com/details/138571371

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"So those in the vaccine arm did worse" You just validated DCVAXs ability to get TCELLs etc to the tumor. BRAVO

The vaccine did worse on progression. No chit sherlock. When you measure with innacurate tools that do not dentify freind or foe that is what will happen. You will come to the wrong concclusion. Especially when something happens that your not expecting. Like living 10 years after supposedly progressing with GBM. News flash, not progression. It's immune agression.

What the world really needs is the ability to measure cell types non invassively without biopsy in real time.

Ask those 27 alive if any harm was done. Nice try, but at least you will get a participation trophy.

Unleash Direct Method B!